Corneal Complications of Herpes Zoster Ophthalmicus: Prevention and Treatment
Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and expo-sure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in red...
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| Veröffentlicht in: | Cornea 1988-01, Vol.7 (1), p.50-56 |
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| creator | Cobo, L Michael |
| description | Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and expo-sure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence of early pseudodendritic keratopathy and stromal keratitis but has no evident effect on exposure/neurotrophic keratopathy. Although early pseudodendritic keratitis is due to virus infection of epithelial cells, it is self-limited and does not require topical antiviral therapy. Stromal keratitis and associated epithelial mucous adherent keratopathy are responsive to topical corticosteroids but chronic therapy is often required and may prolong the duration of keratitis and result in cataract or secondary glaucoma. Exposure and neurotrophic keratopathy may respond to topical lubricants and correction of lid abnormalities but severely affected corneas may require tarsorrhaphy or conjuctival flap to maintain corneal integrity. |
| doi_str_mv | 10.1097/00003226-198801000-00007 |
| format | Article |
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Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence of early pseudodendritic keratopathy and stromal keratitis but has no evident effect on exposure/neurotrophic keratopathy. Although early pseudodendritic keratitis is due to virus infection of epithelial cells, it is self-limited and does not require topical antiviral therapy. Stromal keratitis and associated epithelial mucous adherent keratopathy are responsive to topical corticosteroids but chronic therapy is often required and may prolong the duration of keratitis and result in cataract or secondary glaucoma. Exposure and neurotrophic keratopathy may respond to topical lubricants and correction of lid abnormalities but severely affected corneas may require tarsorrhaphy or conjuctival flap to maintain corneal integrity.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/00003226-198801000-00007</identifier><identifier>PMID: 3258220</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>Acyclovir - therapeutic use ; Administration, Oral ; Administration, Topical ; Adrenal Cortex Hormones - therapeutic use ; Antiviral Agents - therapeutic use ; Cornea - pathology ; Corneal Diseases - classification ; Corneal Diseases - drug therapy ; Corneal Diseases - etiology ; Corneal Diseases - prevention & control ; Corneal Stroma ; Herpes Zoster Ophthalmicus - complications ; Humans ; Keratitis - drug therapy ; Keratitis - etiology ; Lubrication</subject><ispartof>Cornea, 1988-01, Vol.7 (1), p.50-56</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4507-92c0899d6907877c5fb53af06d01b87827e3e274cb45b20512e3011ad60717c03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3258220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cobo, L Michael</creatorcontrib><title>Corneal Complications of Herpes Zoster Ophthalmicus: Prevention and Treatment</title><title>Cornea</title><addtitle>Cornea</addtitle><description>Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and expo-sure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence of early pseudodendritic keratopathy and stromal keratitis but has no evident effect on exposure/neurotrophic keratopathy. Although early pseudodendritic keratitis is due to virus infection of epithelial cells, it is self-limited and does not require topical antiviral therapy. Stromal keratitis and associated epithelial mucous adherent keratopathy are responsive to topical corticosteroids but chronic therapy is often required and may prolong the duration of keratitis and result in cataract or secondary glaucoma. Exposure and neurotrophic keratopathy may respond to topical lubricants and correction of lid abnormalities but severely affected corneas may require tarsorrhaphy or conjuctival flap to maintain corneal integrity.</description><subject>Acyclovir - therapeutic use</subject><subject>Administration, Oral</subject><subject>Administration, Topical</subject><subject>Adrenal Cortex Hormones - therapeutic use</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Cornea - pathology</subject><subject>Corneal Diseases - classification</subject><subject>Corneal Diseases - drug therapy</subject><subject>Corneal Diseases - etiology</subject><subject>Corneal Diseases - prevention & control</subject><subject>Corneal Stroma</subject><subject>Herpes Zoster Ophthalmicus - complications</subject><subject>Humans</subject><subject>Keratitis - drug therapy</subject><subject>Keratitis - etiology</subject><subject>Lubrication</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P5DAMhiPEahg-fgJSTty6OElbp9zQiI-VQOxh9rKXKE1dTaFtStKC9t9vhxm44Yvl169t6TFjXMBPAQVewhxKyjwRhdYg5irZSnjAliJTeZJioQ_ZEiRiojCFI3Yc4_PWgblcsIWSmZYSluxx5UNPtuUr3w1t4-zY-D5yX_N7CgNF_tfHkQJ_GjbjxrZd46Z4xX8HeqN-a-W2r_g6kB27WThlP2rbRjrb5xP25_ZmvbpPHp7ufq2uHxKXZoBJIR3ooqjyAlAjuqwuM2VryCsQpUYtkRRJTF2ZZqWETEhSIIStckCBDtQJu9jtHYJ_nSiOpmuio7a1PfkpGtQizYTWs1HvjC74GAPVZghNZ8M_I8BsSZpPkuaL5IeE8-j5_sZUdlR9De7Rzf1013_37UwovrTTOwWzmWGOG_Pdg9R_YEB8vA</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>Cobo, L Michael</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880101</creationdate><title>Corneal Complications of Herpes Zoster Ophthalmicus: Prevention and Treatment</title><author>Cobo, L Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4507-92c0899d6907877c5fb53af06d01b87827e3e274cb45b20512e3011ad60717c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acyclovir - therapeutic use</topic><topic>Administration, Oral</topic><topic>Administration, Topical</topic><topic>Adrenal Cortex Hormones - therapeutic use</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Cornea - pathology</topic><topic>Corneal Diseases - classification</topic><topic>Corneal Diseases - drug therapy</topic><topic>Corneal Diseases - etiology</topic><topic>Corneal Diseases - prevention & control</topic><topic>Corneal Stroma</topic><topic>Herpes Zoster Ophthalmicus - complications</topic><topic>Humans</topic><topic>Keratitis - drug therapy</topic><topic>Keratitis - etiology</topic><topic>Lubrication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cobo, L Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cobo, L Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corneal Complications of Herpes Zoster Ophthalmicus: Prevention and Treatment</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>7</volume><issue>1</issue><spage>50</spage><epage>56</epage><pages>50-56</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>Corneal complications of herpes zoster ophthalmicus include pseudodendritic keratitis, late mucous adherent keratopathy, varied forms of stromal keratitis, and expo-sure/neurotrophic keratopathy. Prophylactic therapy of acute herpes zoster ophthalmicus with oral acyclovir is of proven benefit in reducing the incidence of early pseudodendritic keratopathy and stromal keratitis but has no evident effect on exposure/neurotrophic keratopathy. Although early pseudodendritic keratitis is due to virus infection of epithelial cells, it is self-limited and does not require topical antiviral therapy. Stromal keratitis and associated epithelial mucous adherent keratopathy are responsive to topical corticosteroids but chronic therapy is often required and may prolong the duration of keratitis and result in cataract or secondary glaucoma. 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| fulltext | fulltext |
| identifier | ISSN: 0277-3740 |
| ispartof | Cornea, 1988-01, Vol.7 (1), p.50-56 |
| issn | 0277-3740 1536-4798 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acyclovir - therapeutic use Administration, Oral Administration, Topical Adrenal Cortex Hormones - therapeutic use Antiviral Agents - therapeutic use Cornea - pathology Corneal Diseases - classification Corneal Diseases - drug therapy Corneal Diseases - etiology Corneal Diseases - prevention & control Corneal Stroma Herpes Zoster Ophthalmicus - complications Humans Keratitis - drug therapy Keratitis - etiology Lubrication |
| title | Corneal Complications of Herpes Zoster Ophthalmicus: Prevention and Treatment |
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