Atrial natriuretic peptide induces breakdown of phosphatidylinositol phosphates in cultured vascular smooth‐muscle cells

Discrepancies exist between extent of guanylate cyclase activation by atrial natriuretic peptide (ANP) in cell‐free systems and ANP‐stimulated levels of cyclic GMP in whole cells, and also between receptor affinity and dose effectiveness of ANP. Therefore, we have investigated whether, in addition t...

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Veröffentlicht in:	European journal of biochemistry 1988-03, Vol.172 (2), p.499-505
Hauptverfasser:	RESINK, Thérèse J., SCOTT‐BURDEN, Timothy, BAUR, Ursula, JONES, C. Richard, BÜHLER, Fritz R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Aorta, Thoracic - metabolism Arachidonic Acid Arachidonic Acids - metabolism Atrial Natriuretic Factor - pharmacology Binding Sites - drug effects Biological and medical sciences Cell physiology Cells, Cultured Cyclic AMP - metabolism Cyclic GMP - metabolism Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Guanylate Cyclase - metabolism Hormonal regulation Humans Molecular and cellular biology Muscle, Smooth, Vascular - metabolism Phosphatidylinositols - metabolism Rats
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