The association of in vitro arachidonic acid responsiveness and plasma thromboxane levels with early platelet deposition on the luminal surface of small-diameter grafts

The response of canine platelets to arachidonic acid (AA) stimulation was studied as a predictor of thrombotic potential. Fifty mongrel dogs underwent in vitro platelet aggregation studies with adenosine diphosphate (ADP), collagen, and AA used as inducing agents. Thirty-two dogs were selected on th...

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Veröffentlicht in:	Journal of vascular surgery 1988-04, Vol.7 (4), p.554-561
Hauptverfasser:	Freeman, Michael B., Sicard, Gregorio A., Valentin, Leonardo I., Neuberger, Sonia, Mangino, Martin J., Anderson, Charles B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid Arachidonic Acids - pharmacology Aspirin - therapeutic use Benzofurans - therapeutic use Blood Vessel Prosthesis Dogs Graft Occlusion, Vascular - etiology Graft Occlusion, Vascular - prevention & control Platelet Aggregation - drug effects Polytetrafluoroethylene Thromboxane B2 - blood Thromboxane-A Synthase - antagonists & inhibitors
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