Identification of chiral drug isomers by capillary electrophoresis
Separation of optical isomers of compounds of pharmaceutical interest by capillary electrophoretic techniques is reviewed. The direct and indirect separation method, as well as the main resolution mechanisms and the parameters influencing the stereoselectivity are discussed considering capillary zon...
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| Veröffentlicht in: | Journal of Chromatography A 1996-05, Vol.735 (1), p.77-121 |
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| container_end_page | 121 |
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| container_title | Journal of Chromatography A |
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| creator | Fanali, Salvatore |
| description | Separation of optical isomers of compounds of pharmaceutical interest by capillary electrophoretic techniques is reviewed. The direct and indirect separation method, as well as the main resolution mechanisms and the parameters influencing the stereoselectivity are discussed considering capillary zone electrophoresis, micellar electrokinetic chromatography, isotachophoresis and electrochromatography. Several chiral selectors have been successfully used in CE for chiral separation, including cyclodextrins and their derivatives, modified crown-ethers, proteins, antibiotics, linear saccharides and chiral surfactants. Only applications in the pharmaceutical field with the most important experimental conditions are summarised in the Tables reported in this paper. The chiral analyses of drugs in real samples like biological fluids or pharmaceutical formulations are also reported. |
| doi_str_mv | 10.1016/0021-9673(95)01327-X |
| format | Article |
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The direct and indirect separation method, as well as the main resolution mechanisms and the parameters influencing the stereoselectivity are discussed considering capillary zone electrophoresis, micellar electrokinetic chromatography, isotachophoresis and electrochromatography. Several chiral selectors have been successfully used in CE for chiral separation, including cyclodextrins and their derivatives, modified crown-ethers, proteins, antibiotics, linear saccharides and chiral surfactants. Only applications in the pharmaceutical field with the most important experimental conditions are summarised in the Tables reported in this paper. 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The direct and indirect separation method, as well as the main resolution mechanisms and the parameters influencing the stereoselectivity are discussed considering capillary zone electrophoresis, micellar electrokinetic chromatography, isotachophoresis and electrochromatography. Several chiral selectors have been successfully used in CE for chiral separation, including cyclodextrins and their derivatives, modified crown-ethers, proteins, antibiotics, linear saccharides and chiral surfactants. Only applications in the pharmaceutical field with the most important experimental conditions are summarised in the Tables reported in this paper. The chiral analyses of drugs in real samples like biological fluids or pharmaceutical formulations are also reported.</description><subject>Antibiotics</subject><subject>Body Fluids - chemistry</subject><subject>Crown ethers</subject><subject>Cyclodextrins</subject><subject>Drugs</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Electrophoresis, Capillary - statistics & numerical data</subject><subject>Enantiomer separation</subject><subject>Humans</subject><subject>Micelles</subject><subject>Pharmaceutical analysis</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical Preparations - isolation & purification</subject><subject>Reviews</subject><subject>Stereoisomerism</subject><subject>Technology, Pharmaceutical</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhnNQaq3-A4U9iR5W87FJmougxY9CwYtCbyGbzNrI7qYmu0L_vVtbevQ0MPO-78w8CF0QfEswEXcYU5IrIdm14jeYMCrz5REaH9on6DSlL4yJxJKO0GgqhZRMjdHj3EHb-cpb0_nQZqHK7MpHU2cu9p-ZT6GBmLJyk1mz9nVt4iaDGmwXw3oVIiSfztBxZeoE5_s6QR_PT--z13zx9jKfPSxyW1DW5Y4TKKRgSpUFFIQBZ5YL7ox1jAhOMOayUIJiwxlVBktpcekoppKCsoqwCbra5a5j-O4hdbrxycJwUwuhT1pOSVFQMR2ExU5oY0gpQqXX0TfD5ZpgvcWlt1z0lotWXP_h0svBdrnP78sG3MG0ZzXM73dzGJ788RB1sh5aC87HAYh2wf-_4BeVcXrK</recordid><startdate>19960531</startdate><enddate>19960531</enddate><creator>Fanali, Salvatore</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960531</creationdate><title>Identification of chiral drug isomers by capillary electrophoresis</title><author>Fanali, Salvatore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d51e476399b4e413e53c565dacd31651005749620a5329a077c0bd20272e9c913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Antibiotics</topic><topic>Body Fluids - chemistry</topic><topic>Crown ethers</topic><topic>Cyclodextrins</topic><topic>Drugs</topic><topic>Electrophoresis, Capillary - methods</topic><topic>Electrophoresis, Capillary - statistics & numerical data</topic><topic>Enantiomer separation</topic><topic>Humans</topic><topic>Micelles</topic><topic>Pharmaceutical analysis</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical Preparations - isolation & purification</topic><topic>Reviews</topic><topic>Stereoisomerism</topic><topic>Technology, Pharmaceutical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fanali, Salvatore</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fanali, Salvatore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of chiral drug isomers by capillary electrophoresis</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>1996-05-31</date><risdate>1996</risdate><volume>735</volume><issue>1</issue><spage>77</spage><epage>121</epage><pages>77-121</pages><issn>0021-9673</issn><abstract>Separation of optical isomers of compounds of pharmaceutical interest by capillary electrophoretic techniques is reviewed. 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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antibiotics Body Fluids - chemistry Crown ethers Cyclodextrins Drugs Electrophoresis, Capillary - methods Electrophoresis, Capillary - statistics & numerical data Enantiomer separation Humans Micelles Pharmaceutical analysis Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification Reviews Stereoisomerism Technology, Pharmaceutical |
| title | Identification of chiral drug isomers by capillary electrophoresis |
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