Small bowel disaccharidase activity in the rat as affected by intestinal resection and pectin feeding
This study investigated the effects of small bowel resection (SBR) and a pectin-supplemented elemental diet (ED) on intestinal disaccharidase activity. Rats underwent placement of feeding gastrostomy and swivel apparatus. Control animals were returned to their cages while resected animals underwent...
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| Veröffentlicht in: | The American journal of clinical nutrition 1988-03, Vol.47 (3), p.448-453 |
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| container_title | The American journal of clinical nutrition |
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| creator | Koruda, MJ Rolandelli, RH Settle, RG Rombeau, JL |
| description | This study investigated the effects of small bowel resection (SBR) and a pectin-supplemented elemental diet (ED) on intestinal disaccharidase activity. Rats underwent placement of feeding gastrostomy and swivel apparatus. Control animals were returned to their cages while resected animals underwent an 80% SBR. Postoperatively, animals received either a pectin-free ED or the ED supplemented with 2% pectin. After 2 wk jejunal and ileal mucosal sucrase, maltase, and lactase activities and protein content were determined. Feeding the ED after SBR resulted in significant increases in all three ileal segmental disaccharidase activities but only maltase activity was significantly increased in the jejunum. The pectin-supplemented ED, however, significantly enhanced the adaptation of jejunal and ileal segmental sucrase, maltase, and lactase activity to SBR with the increase in all three jejunal disaccharidase activities being significantly greater than that of the resected animals fed the ED alone. |
| doi_str_mv | 10.1093/ajcn/47.3.448 |
| format | Article |
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Rats underwent placement of feeding gastrostomy and swivel apparatus. Control animals were returned to their cages while resected animals underwent an 80% SBR. Postoperatively, animals received either a pectin-free ED or the ED supplemented with 2% pectin. After 2 wk jejunal and ileal mucosal sucrase, maltase, and lactase activities and protein content were determined. Feeding the ED after SBR resulted in significant increases in all three ileal segmental disaccharidase activities but only maltase activity was significantly increased in the jejunum. The pectin-supplemented ED, however, significantly enhanced the adaptation of jejunal and ileal segmental sucrase, maltase, and lactase activity to SBR with the increase in all three jejunal disaccharidase activities being significantly greater than that of the resected animals fed the ED alone.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/47.3.448</identifier><identifier>PMID: 3126640</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adaptation, Physiological ; alpha-Glucosidases - metabolism ; Animals ; beta-Galactosidase - metabolism ; Biological and medical sciences ; Disaccharidases - metabolism ; Food, Formulated ; Intestinal Absorption ; Intestine, Small - enzymology ; Intestine, Small - physiology ; Male ; Medical sciences ; Pectins - administration & dosage ; Rats ; Stomach, duodenum, intestine, rectum, anus ; Sucrase - metabolism ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Rats underwent placement of feeding gastrostomy and swivel apparatus. Control animals were returned to their cages while resected animals underwent an 80% SBR. Postoperatively, animals received either a pectin-free ED or the ED supplemented with 2% pectin. After 2 wk jejunal and ileal mucosal sucrase, maltase, and lactase activities and protein content were determined. Feeding the ED after SBR resulted in significant increases in all three ileal segmental disaccharidase activities but only maltase activity was significantly increased in the jejunum. The pectin-supplemented ED, however, significantly enhanced the adaptation of jejunal and ileal segmental sucrase, maltase, and lactase activity to SBR with the increase in all three jejunal disaccharidase activities being significantly greater than that of the resected animals fed the ED alone.</description><subject>Adaptation, Physiological</subject><subject>alpha-Glucosidases - metabolism</subject><subject>Animals</subject><subject>beta-Galactosidase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Disaccharidases - metabolism</subject><subject>Food, Formulated</subject><subject>Intestinal Absorption</subject><subject>Intestine, Small - enzymology</subject><subject>Intestine, Small - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pectins - administration & dosage</subject><subject>Rats</subject><subject>Stomach, duodenum, intestine, rectum, anus</subject><subject>Sucrase - metabolism</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PGzEQhi1UlKaBI8dKPlTcNrF3vF_HCrUUCakH4GzN2mMw2nhTe0OVf49XibhxmtG8j0YzD2NXUqyl6GCDryZsVLOGtVLtGVvKDtoCStF8YUshRFl0sq6-sm8pvQohS9XWC7YAWda1EktGD1scBt6P_2ng1ic05gWjt5iIo5n8m58O3Ac-vRCPOHFMHJ0jM5Hl_ZxMlCYfcOCRUh77MXAMlu_mPnBHZH14vmDnDodEl6e6Yk-_fz3e_Cnu_97e3fy8LwzU1VRUUFEvBCojqbXKCQlYgUWQVdm5CqDtULZWSjKIpnNSgel66wSRcDX1sGLXx727OP7b58v01idDw4CBxn3STStV2QBksDiCJo4pRXJ6F_0W40FLoWetetaqVaNBZ62Z_35avO-3ZD_ok8ec_zjlmAwOLmIwPn1gTZ1fq2esOWKUJbx5ijoZT8FkSTEL03b0nxzwDkeFlN4</recordid><startdate>19880301</startdate><enddate>19880301</enddate><creator>Koruda, MJ</creator><creator>Rolandelli, RH</creator><creator>Settle, RG</creator><creator>Rombeau, JL</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880301</creationdate><title>Small bowel disaccharidase activity in the rat as affected by intestinal resection and pectin feeding</title><author>Koruda, MJ ; Rolandelli, RH ; Settle, RG ; Rombeau, JL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-535eb00a4c1e8d4f013a53da31529f53389a18d11ecaac9f143c9bdf0ee0f6eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adaptation, Physiological</topic><topic>alpha-Glucosidases - metabolism</topic><topic>Animals</topic><topic>beta-Galactosidase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Disaccharidases - metabolism</topic><topic>Food, Formulated</topic><topic>Intestinal Absorption</topic><topic>Intestine, Small - enzymology</topic><topic>Intestine, Small - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pectins - administration & dosage</topic><topic>Rats</topic><topic>Stomach, duodenum, intestine, rectum, anus</topic><topic>Sucrase - metabolism</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koruda, MJ</creatorcontrib><creatorcontrib>Rolandelli, RH</creatorcontrib><creatorcontrib>Settle, RG</creatorcontrib><creatorcontrib>Rombeau, JL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koruda, MJ</au><au>Rolandelli, RH</au><au>Settle, RG</au><au>Rombeau, JL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small bowel disaccharidase activity in the rat as affected by intestinal resection and pectin feeding</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1988-03-01</date><risdate>1988</risdate><volume>47</volume><issue>3</issue><spage>448</spage><epage>453</epage><pages>448-453</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>This study investigated the effects of small bowel resection (SBR) and a pectin-supplemented elemental diet (ED) on intestinal disaccharidase activity. Rats underwent placement of feeding gastrostomy and swivel apparatus. Control animals were returned to their cages while resected animals underwent an 80% SBR. Postoperatively, animals received either a pectin-free ED or the ED supplemented with 2% pectin. After 2 wk jejunal and ileal mucosal sucrase, maltase, and lactase activities and protein content were determined. Feeding the ED after SBR resulted in significant increases in all three ileal segmental disaccharidase activities but only maltase activity was significantly increased in the jejunum. The pectin-supplemented ED, however, significantly enhanced the adaptation of jejunal and ileal segmental sucrase, maltase, and lactase activity to SBR with the increase in all three jejunal disaccharidase activities being significantly greater than that of the resected animals fed the ED alone.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>3126640</pmid><doi>10.1093/ajcn/47.3.448</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9165 |
| ispartof | The American journal of clinical nutrition, 1988-03, Vol.47 (3), p.448-453 |
| issn | 0002-9165 1938-3207 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adaptation, Physiological alpha-Glucosidases - metabolism Animals beta-Galactosidase - metabolism Biological and medical sciences Disaccharidases - metabolism Food, Formulated Intestinal Absorption Intestine, Small - enzymology Intestine, Small - physiology Male Medical sciences Pectins - administration & dosage Rats Stomach, duodenum, intestine, rectum, anus Sucrase - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system |
| title | Small bowel disaccharidase activity in the rat as affected by intestinal resection and pectin feeding |
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