Essential thrombocythemia with BCR/ABL rearrangement
Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive, bcr-abl positive, whereas the third was Ph negative, bcr-...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 1996-07, Vol.89 (1), p.74-76 |
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| container_title | Cancer genetics and cytogenetics |
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| creator | Kwong, Y.L. Chiu, E.K.W. Liang, R.H.S. Chan, Vivian Chan, T.K. |
| description | Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the
bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive,
bcr-abl positive, whereas the third was Ph negative,
bcr-abl positive. The first patient received an allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement. |
| doi_str_mv | 10.1016/0165-4608(94)00108-1 |
| format | Article |
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bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive,
bcr-abl positive, whereas the third was Ph negative,
bcr-abl positive. The first patient received an allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/0165-4608(94)00108-1</identifier><identifier>PMID: 8689617</identifier><identifier>CODEN: CGCYDF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Base Sequence ; Biological and medical sciences ; Fusion Proteins, bcr-abl - genetics ; Gene Rearrangement ; Hematologic and hematopoietic diseases ; Humans ; Male ; Medical sciences ; Molecular Sequence Data ; Platelet diseases and coagulopathies ; Thrombocytosis - genetics</subject><ispartof>Cancer genetics and cytogenetics, 1996-07, Vol.89 (1), p.74-76</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-24027b8727b812d3ff2d42ed24047b44b954ff870dfa53b083878306b86deadb3</citedby><cites>FETCH-LOGICAL-c301t-24027b8727b812d3ff2d42ed24047b44b954ff870dfa53b083878306b86deadb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-4608(94)00108-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3157249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8689617$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwong, Y.L.</creatorcontrib><creatorcontrib>Chiu, E.K.W.</creatorcontrib><creatorcontrib>Liang, R.H.S.</creatorcontrib><creatorcontrib>Chan, Vivian</creatorcontrib><creatorcontrib>Chan, T.K.</creatorcontrib><title>Essential thrombocythemia with BCR/ABL rearrangement</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the
bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive,
bcr-abl positive, whereas the third was Ph negative,
bcr-abl positive. The first patient received an allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement.</description><subject>Adult</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Fusion Proteins, bcr-abl - genetics</subject><subject>Gene Rearrangement</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Platelet diseases and coagulopathies</subject><subject>Thrombocytosis - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN9LwzAQgIMoc07_A4U9iOhDXdKkSfoibGP-gIEg-hzS5Ooi7apJp-y_N3Vljz7cHdx9dxwfQucE3xJM-CRGljCO5XXObjAmWCbkAA2JFDRhLOOHaLhHjtFJCB8YY5HmfIAGksucEzFEbBECrFunq3G78k1dNGbbrqB2evzj2tV4Nn-ZTGfLsQftvV6_Qx3pU3RU6irAWV9H6O1-8Tp_TJbPD0_z6TIxFJM2SRlORSFFl0hqaVmmlqVgY5-JgrEiz1hZSoFtqTNaYEmlkBTzQnIL2hZ0hK52dz9987WB0KraBQNVpdfQbIISkrCUcxpBtgONb0LwUKpP72rtt4pg1clSnQnVmVA5U3-yFIlrF_39TVGD3S_1duL8sp_rYHRVRgHGhT1GSSZSlkfsbodBdPHtwKtgHKwNWOfBtMo27v8_fgF7a4OS</recordid><startdate>19960701</startdate><enddate>19960701</enddate><creator>Kwong, Y.L.</creator><creator>Chiu, E.K.W.</creator><creator>Liang, R.H.S.</creator><creator>Chan, Vivian</creator><creator>Chan, T.K.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960701</creationdate><title>Essential thrombocythemia with BCR/ABL rearrangement</title><author>Kwong, Y.L. ; Chiu, E.K.W. ; Liang, R.H.S. ; Chan, Vivian ; Chan, T.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-24027b8727b812d3ff2d42ed24047b44b954ff870dfa53b083878306b86deadb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Fusion Proteins, bcr-abl - genetics</topic><topic>Gene Rearrangement</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Platelet diseases and coagulopathies</topic><topic>Thrombocytosis - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Kwong, Y.L.</creatorcontrib><creatorcontrib>Chiu, E.K.W.</creatorcontrib><creatorcontrib>Liang, R.H.S.</creatorcontrib><creatorcontrib>Chan, Vivian</creatorcontrib><creatorcontrib>Chan, T.K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwong, Y.L.</au><au>Chiu, E.K.W.</au><au>Liang, R.H.S.</au><au>Chan, Vivian</au><au>Chan, T.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Essential thrombocythemia with BCR/ABL rearrangement</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>1996-07-01</date><risdate>1996</risdate><volume>89</volume><issue>1</issue><spage>74</spage><epage>76</epage><pages>74-76</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><coden>CGCYDF</coden><abstract>Essential thrombocythemia (ET) was diagnosed clinically in three patients. Karyotypic analysis and reverse transcription polymerase chain reaction for the
bcr-abl chimeric transcript showed that two were Philadelphia chromosome (Ph) positive,
bcr-abl positive, whereas the third was Ph negative,
bcr-abl positive. The first patient received an allogeneic bone marrow transplantation but relapsed as localized blastic transformation, thus behaving similarly to chronic myeloid leukemia (CML). However, the other patients showed clinical courses more in keeping with ET. Essential thrombocythemia with BCR rearrangements may resemble CML but there are clinical differences. These may be due to genetic changes in addition to the BCR rearrangement.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8689617</pmid><doi>10.1016/0165-4608(94)00108-1</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Base Sequence Biological and medical sciences Fusion Proteins, bcr-abl - genetics Gene Rearrangement Hematologic and hematopoietic diseases Humans Male Medical sciences Molecular Sequence Data Platelet diseases and coagulopathies Thrombocytosis - genetics |
| title | Essential thrombocythemia with BCR/ABL rearrangement |
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