The Antitumor Drug Aclacinomycin A, Which Inhibits the Degradation of Ubiquitinated Proteins, Shows Selectivity for the Chymotrypsin-like Activity of the Bovine Pituitary 20 S Proteasome

The antitumor drug aclacinomycin A was previously shown to inhibit the degradation of ubiquitinated proteins in rabbit reticulocyte lysates with an IC50 of 52 µM (Isoe, T., Naito, M., Shirai, A., Hirai, R., and Tsuruo, T. (1992) Biochim. Biophys. Acta 1117, 131-135). We report here that from all the...

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Veröffentlicht in:	The Journal of biological chemistry 1996-07, Vol.271 (28), p.16455-16459
Hauptverfasser:	Figueiredo-Pereira, Maria E., Chen, Wei Er, Li, Jingrong, Johdo, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aclarubicin - chemistry Aclarubicin - pharmacology Animals Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Catalysis Cattle Chymotrypsin - antagonists & inhibitors Chymotrypsin - metabolism Cysteine Endopeptidases - drug effects Cysteine Endopeptidases - metabolism Hydrolysis Molecular Structure Multienzyme Complexes - drug effects Multienzyme Complexes - metabolism Pituitary Gland - enzymology Proteasome Endopeptidase Complex Proteins - metabolism Ubiquitins - metabolism
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