Platelet-Mediated Lymphocyte Delivery to High Endothelial Venules

Circulating lymphocytes gain access to lymph nodes owing to their ability to initiate rolling along specialized high endothelial venules (HEVs). One mechanism of rolling involves L-selectin binding to peripheral node addressin (PNAd) on HEVs. Activated platelets are shown to bind to circulating lymp...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-07, Vol.273 (5272), p.252-255
Hauptverfasser:	Diacovo, Thomas G., Puri, Kamal D., Warnock, R. Aaron, Springer, Timothy A., von Andrian, Ulrich H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Antigens, Surface - metabolism Biological and medical sciences Blood Blood platelets Blood Platelets - physiology Butchering Cell Adhesion Cell Movement Cellular biology Endothelial cells Endothelium, Vascular - cytology Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins Humans Immunobiology Inhibition L-Selectin - physiology Leukocytes Ligands Lymph Nodes - blood supply Lymph Nodes - cytology Lymphatic system Lymphocytes Lymphocytes - cytology Lymphocytes - physiology Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Lymphokines Membrane Glycoproteins - metabolism Membrane Proteins Mice P-Selectin - metabolism Platelet Activation Platelets Receptors, Lymphocyte Homing - metabolism Transfection Tumor Cells, Cultured Vascular endothelium Venules Venules - cytology
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