Reduced sensitivity to saquinavir: an update on genotyping from phase I/II trials

A genotypic analysis of the HIV-1 proteinase was performed on clinical specimen obtained from patients after different periods of Saquinavir (SQV) treatment. Proteinase genes of integrated proviral DNA from PBMC were isolated by PCR, cloned and individual sequences were obtained. Genotypic resistanc...

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Veröffentlicht in:	Antiviral research 1996, Vol.29 (1), p.95-97
Hauptverfasser:	Jacobsen, H., Haenggi, M., Ott, M., Duncan, I.B., Andreoni, M., Vella, S., Mous, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Resistance, Microbial - genetics Genotype HIV Infections - drug therapy HIV Protease - genetics HIV Protease Inhibitors - pharmacology HIV Protease Inhibitors - therapeutic use HIV-1 - genetics HIV-1 protinease human immunodeficiency virus 1 Humans Inhibitors Isoquinolines - pharmacology Isoquinolines - therapeutic use Medical sciences Mutation Pharmacology. Drug treatments Quinolines - pharmacology Quinolines - therapeutic use Saquinavir
Online-Zugang:	Volltext
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