Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus
The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-07, Vol.273 (5272), p.228-231 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 231 |
|---|---|
| container_issue | 5272 |
| container_start_page | 228 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 273 |
| creator | Karp, Christopher L. Wysocka, Maria Wahl, Larry M. Ahearn, Joseph M. Cuomo, Peter J. Sherry, Barbara Trinchieri, Giorgio Griffin, Diane E. |
| description | The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses. |
| doi_str_mv | 10.1126/science.273.5272.228 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_78139536</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A18500961</galeid><jstor_id>2890417</jstor_id><sourcerecordid>A18500961</sourcerecordid><originalsourceid>FETCH-LOGICAL-c811t-6ba44dc0bdd3d50faecffa0c8add7bb565bb74006387cb6fb341d11dc42fe9193</originalsourceid><addsrcrecordid>eNqN0luLEzEUB_BBlLW7-g1WGERWH3ZqLpPLPK5Fa6G1D6v7GjLJmZoyl5rMgP32prQUKkVLHkJyfjkk5J8ktxiNMSb8YzAOWgNjIuiYEUHGhMhnyQijgmUFQfR5MkKI8kwiwV4m1yGsEYq1gl4lV5JzwlA-SiYLMD9160KTdlX6OGw2HkJwXbtbTqCuswVYp3uw6axphtb127TcpgvQoYaQPjk_hFfJi0rXAV4f5pvkx5fP3ydfs_lyOps8zDMjMe4zXuo8twaV1lLLUKXBVJVGRmprRVkyzspS5AhxKoUpeVXSHFuMrclJBQUu6E1yt--78d2vAUKvGhdMvKNuoRuCEhLTglEe4ft_w5wSwSVn_22JGRM5oyLCt3_BdTf4Nj5XEUwZp4jt0P0erXQNyrVV13ttVtCC13XXQuXi9gOWLP4Dx5FnZ3gcFhpnzvkPJz6SHn73Kz2EoGaP3y6my6eL6afppVRO5yf0_hw1XV3DClTMxWR5wvM9N74LwUOlNt412m8VRmqXdnVIu4ppV7u0q5j2eOzN4VeGsgF7PHSId6y_O9R1MLquvG6NC0dGMZOY08hu92wd-s4fy0QWKMeC_gFCaAzX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213563057</pqid></control><display><type>article</type><title>Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus</title><source>MEDLINE</source><source>Science Magazine</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Karp, Christopher L. ; Wysocka, Maria ; Wahl, Larry M. ; Ahearn, Joseph M. ; Cuomo, Peter J. ; Sherry, Barbara ; Trinchieri, Giorgio ; Griffin, Diane E.</creator><creatorcontrib>Karp, Christopher L. ; Wysocka, Maria ; Wahl, Larry M. ; Ahearn, Joseph M. ; Cuomo, Peter J. ; Sherry, Barbara ; Trinchieri, Giorgio ; Griffin, Diane E.</creatorcontrib><description>The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.273.5272.228</identifier><identifier>PMID: 8662504</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Antibodies ; Antibodies, Monoclonal ; Antigens, CD - immunology ; Antigens, CD - physiology ; B lymphocytes ; Binding Sites ; Biological and medical sciences ; Cells, Cultured ; Cellular biology ; Chemokines - biosynthesis ; Complement C3b - immunology ; Complement C3b - physiology ; Computer Managed Instruction ; Cytokines ; Cytokines - biosynthesis ; Down-Regulation ; Fundamental and applied biological sciences. Psychology ; HIV ; Humans ; Immune Tolerance ; Immunity (Disease) ; Immunosuppression ; Infections ; Inhibition ; Interleukin-10 - physiology ; Interleukin-12 - biosynthesis ; Macrophages ; Measles ; Measles virus ; Measles virus - immunology ; Measles virus - metabolism ; Membrane Cofactor Protein ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - physiology ; Microbiology ; Monocytes ; Monocytes - immunology ; Monocytes - virology ; Natural killer cells ; Proteins ; Receptors, Virus - immunology ; Receptors, Virus - physiology ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Virology</subject><ispartof>Science (American Association for the Advancement of Science), 1996-07, Vol.273 (5272), p.228-231</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 12, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c811t-6ba44dc0bdd3d50faecffa0c8add7bb565bb74006387cb6fb341d11dc42fe9193</citedby><cites>FETCH-LOGICAL-c811t-6ba44dc0bdd3d50faecffa0c8add7bb565bb74006387cb6fb341d11dc42fe9193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2890417$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2890417$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3158163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8662504$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karp, Christopher L.</creatorcontrib><creatorcontrib>Wysocka, Maria</creatorcontrib><creatorcontrib>Wahl, Larry M.</creatorcontrib><creatorcontrib>Ahearn, Joseph M.</creatorcontrib><creatorcontrib>Cuomo, Peter J.</creatorcontrib><creatorcontrib>Sherry, Barbara</creatorcontrib><creatorcontrib>Trinchieri, Giorgio</creatorcontrib><creatorcontrib>Griffin, Diane E.</creatorcontrib><title>Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.</description><subject>Antibodies</subject><subject>Antibodies, Monoclonal</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - physiology</subject><subject>B lymphocytes</subject><subject>Binding Sites</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Cellular biology</subject><subject>Chemokines - biosynthesis</subject><subject>Complement C3b - immunology</subject><subject>Complement C3b - physiology</subject><subject>Computer Managed Instruction</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Down-Regulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immunity (Disease)</subject><subject>Immunosuppression</subject><subject>Infections</subject><subject>Inhibition</subject><subject>Interleukin-10 - physiology</subject><subject>Interleukin-12 - biosynthesis</subject><subject>Macrophages</subject><subject>Measles</subject><subject>Measles virus</subject><subject>Measles virus - immunology</subject><subject>Measles virus - metabolism</subject><subject>Membrane Cofactor Protein</subject><subject>Membrane Glycoproteins - immunology</subject><subject>Membrane Glycoproteins - physiology</subject><subject>Microbiology</subject><subject>Monocytes</subject><subject>Monocytes - immunology</subject><subject>Monocytes - virology</subject><subject>Natural killer cells</subject><subject>Proteins</subject><subject>Receptors, Virus - immunology</subject><subject>Receptors, Virus - physiology</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Virology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0luLEzEUB_BBlLW7-g1WGERWH3ZqLpPLPK5Fa6G1D6v7GjLJmZoyl5rMgP32prQUKkVLHkJyfjkk5J8ktxiNMSb8YzAOWgNjIuiYEUHGhMhnyQijgmUFQfR5MkKI8kwiwV4m1yGsEYq1gl4lV5JzwlA-SiYLMD9160KTdlX6OGw2HkJwXbtbTqCuswVYp3uw6axphtb127TcpgvQoYaQPjk_hFfJi0rXAV4f5pvkx5fP3ydfs_lyOps8zDMjMe4zXuo8twaV1lLLUKXBVJVGRmprRVkyzspS5AhxKoUpeVXSHFuMrclJBQUu6E1yt--78d2vAUKvGhdMvKNuoRuCEhLTglEe4ft_w5wSwSVn_22JGRM5oyLCt3_BdTf4Nj5XEUwZp4jt0P0erXQNyrVV13ttVtCC13XXQuXi9gOWLP4Dx5FnZ3gcFhpnzvkPJz6SHn73Kz2EoGaP3y6my6eL6afppVRO5yf0_hw1XV3DClTMxWR5wvM9N74LwUOlNt412m8VRmqXdnVIu4ppV7u0q5j2eOzN4VeGsgF7PHSId6y_O9R1MLquvG6NC0dGMZOY08hu92wd-s4fy0QWKMeC_gFCaAzX</recordid><startdate>19960712</startdate><enddate>19960712</enddate><creator>Karp, Christopher L.</creator><creator>Wysocka, Maria</creator><creator>Wahl, Larry M.</creator><creator>Ahearn, Joseph M.</creator><creator>Cuomo, Peter J.</creator><creator>Sherry, Barbara</creator><creator>Trinchieri, Giorgio</creator><creator>Griffin, Diane E.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19960712</creationdate><title>Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus</title><author>Karp, Christopher L. ; Wysocka, Maria ; Wahl, Larry M. ; Ahearn, Joseph M. ; Cuomo, Peter J. ; Sherry, Barbara ; Trinchieri, Giorgio ; Griffin, Diane E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c811t-6ba44dc0bdd3d50faecffa0c8add7bb565bb74006387cb6fb341d11dc42fe9193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Antibodies</topic><topic>Antibodies, Monoclonal</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, CD - physiology</topic><topic>B lymphocytes</topic><topic>Binding Sites</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Cellular biology</topic><topic>Chemokines - biosynthesis</topic><topic>Complement C3b - immunology</topic><topic>Complement C3b - physiology</topic><topic>Computer Managed Instruction</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Down-Regulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immunity (Disease)</topic><topic>Immunosuppression</topic><topic>Infections</topic><topic>Inhibition</topic><topic>Interleukin-10 - physiology</topic><topic>Interleukin-12 - biosynthesis</topic><topic>Macrophages</topic><topic>Measles</topic><topic>Measles virus</topic><topic>Measles virus - immunology</topic><topic>Measles virus - metabolism</topic><topic>Membrane Cofactor Protein</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Microbiology</topic><topic>Monocytes</topic><topic>Monocytes - immunology</topic><topic>Monocytes - virology</topic><topic>Natural killer cells</topic><topic>Proteins</topic><topic>Receptors, Virus - immunology</topic><topic>Receptors, Virus - physiology</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karp, Christopher L.</creatorcontrib><creatorcontrib>Wysocka, Maria</creatorcontrib><creatorcontrib>Wahl, Larry M.</creatorcontrib><creatorcontrib>Ahearn, Joseph M.</creatorcontrib><creatorcontrib>Cuomo, Peter J.</creatorcontrib><creatorcontrib>Sherry, Barbara</creatorcontrib><creatorcontrib>Trinchieri, Giorgio</creatorcontrib><creatorcontrib>Griffin, Diane E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karp, Christopher L.</au><au>Wysocka, Maria</au><au>Wahl, Larry M.</au><au>Ahearn, Joseph M.</au><au>Cuomo, Peter J.</au><au>Sherry, Barbara</au><au>Trinchieri, Giorgio</au><au>Griffin, Diane E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1996-07-12</date><risdate>1996</risdate><volume>273</volume><issue>5272</issue><spage>228</spage><epage>231</epage><pages>228-231</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8662504</pmid><doi>10.1126/science.273.5272.228</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-07, Vol.273 (5272), p.228-231 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78139536 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Antibodies Antibodies, Monoclonal Antigens, CD - immunology Antigens, CD - physiology B lymphocytes Binding Sites Biological and medical sciences Cells, Cultured Cellular biology Chemokines - biosynthesis Complement C3b - immunology Complement C3b - physiology Computer Managed Instruction Cytokines Cytokines - biosynthesis Down-Regulation Fundamental and applied biological sciences. Psychology HIV Humans Immune Tolerance Immunity (Disease) Immunosuppression Infections Inhibition Interleukin-10 - physiology Interleukin-12 - biosynthesis Macrophages Measles Measles virus Measles virus - immunology Measles virus - metabolism Membrane Cofactor Protein Membrane Glycoproteins - immunology Membrane Glycoproteins - physiology Microbiology Monocytes Monocytes - immunology Monocytes - virology Natural killer cells Proteins Receptors, Virus - immunology Receptors, Virus - physiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Virology |
| title | Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T14%3A23%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanism%20of%20Suppression%20of%20Cell-Mediated%20Immunity%20by%20Measles%20Virus&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Karp,%20Christopher%20L.&rft.date=1996-07-12&rft.volume=273&rft.issue=5272&rft.spage=228&rft.epage=231&rft.pages=228-231&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.273.5272.228&rft_dat=%3Cgale_proqu%3EA18500961%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213563057&rft_id=info:pmid/8662504&rft_galeid=A18500961&rft_jstor_id=2890417&rfr_iscdi=true |