Behaviour of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix
A porous collagen sponge can be used for supporting epidermal cells and fibroblasts in order to manufacture an artificial skin. Fibroblasts were grown on analogues of extracellular matrix containing collagen and glycosaminoglycans and/or glycoproteins. Cell replication, and also infiltration of fibr...
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| Veröffentlicht in: | Biomaterials 1988, Vol.9 (1), p.91-96 |
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| creator | Doillon, Charles J. Wasserman, Arthur J. Berg, Richard A. Silver, Frederick H. |
| description | A porous collagen sponge can be used for supporting epidermal cells and fibroblasts in order to manufacture an artificial skin. Fibroblasts were grown on analogues of extracellular matrix containing collagen and glycosaminoglycans and/or glycoproteins. Cell replication, and also infiltration of fibroblasts, were enhanced by the presence of hyaluronic acid and/or fibronectin. Epidermal cells grown on a collagen sponge have been characterized by microscopic observations. Epidermal cells on the surface of the sponge showed an incomplete differentiation in comparison to normal skin; clumps of epidermal cells were found in the interior of the sponge. Epidermal cell replication was enhanced in the presence of collagen sponge seeded with fibroblasts. |
| doi_str_mv | 10.1016/0142-9612(88)90077-4 |
| format | Article |
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Fibroblasts were grown on analogues of extracellular matrix containing collagen and glycosaminoglycans and/or glycoproteins. Cell replication, and also infiltration of fibroblasts, were enhanced by the presence of hyaluronic acid and/or fibronectin. Epidermal cells grown on a collagen sponge have been characterized by microscopic observations. Epidermal cells on the surface of the sponge showed an incomplete differentiation in comparison to normal skin; clumps of epidermal cells were found in the interior of the sponge. Epidermal cell replication was enhanced in the presence of collagen sponge seeded with fibroblasts.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/0142-9612(88)90077-4</identifier><identifier>PMID: 3349126</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Biocompatible Materials ; Cell Differentiation ; Cell Division ; Cells, Cultured ; Chick Embryo ; Collagen ; Epidermal Cells ; Epidermis - drug effects ; Extracellular Matrix ; fibroblasts ; Fibroblasts - cytology ; Fibroblasts - drug effects ; fibronectin ; Fibronectins - pharmacology ; Glycoproteins ; Glycosaminoglycans ; Guinea Pigs ; hyaluronic acid ; Hyaluronic Acid - pharmacology ; Microscopy, Electron</subject><ispartof>Biomaterials, 1988, Vol.9 (1), p.91-96</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-c3102af905ccde41d87f75fb5ecd39eec12567cfd6e08c1bdf7b4c3038149bd43</citedby><cites>FETCH-LOGICAL-c357t-c3102af905ccde41d87f75fb5ecd39eec12567cfd6e08c1bdf7b4c3038149bd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0142-9612(88)90077-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,4023,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3349126$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Doillon, Charles J.</creatorcontrib><creatorcontrib>Wasserman, Arthur J.</creatorcontrib><creatorcontrib>Berg, Richard A.</creatorcontrib><creatorcontrib>Silver, Frederick H.</creatorcontrib><title>Behaviour of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>A porous collagen sponge can be used for supporting epidermal cells and fibroblasts in order to manufacture an artificial skin. Fibroblasts were grown on analogues of extracellular matrix containing collagen and glycosaminoglycans and/or glycoproteins. Cell replication, and also infiltration of fibroblasts, were enhanced by the presence of hyaluronic acid and/or fibronectin. Epidermal cells grown on a collagen sponge have been characterized by microscopic observations. Epidermal cells on the surface of the sponge showed an incomplete differentiation in comparison to normal skin; clumps of epidermal cells were found in the interior of the sponge. Epidermal cell replication was enhanced in the presence of collagen sponge seeded with fibroblasts.</description><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>Collagen</subject><subject>Epidermal Cells</subject><subject>Epidermis - drug effects</subject><subject>Extracellular Matrix</subject><subject>fibroblasts</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>fibronectin</subject><subject>Fibronectins - pharmacology</subject><subject>Glycoproteins</subject><subject>Glycosaminoglycans</subject><subject>Guinea Pigs</subject><subject>hyaluronic acid</subject><subject>Hyaluronic Acid - pharmacology</subject><subject>Microscopy, Electron</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1UkzZt0ougi_9gwYvehJAmE420zZqky_rtbd1lj14yhPnNmzcPoVOCrwgm5TUmNEurkmQXnF9WGDOW0j00JZzxtKhwsY-mO-QQHYXwhYc_ptkETfKcViQrp-j9Dj7lyrreJ84kxtbe1Y0MMSSy0wksrQbfyiZR0DQhUX0T7UpG0InrBkI27qOHMI7COno5Un0jfdLK6O36GB0Y2QQ42dYZenu4f50_pYuXx-f57SJVecHi8BKcSTNYVkoDJZozwwpTF6B0XgEokhUlU0aXgLkitTaspirHOSe0qjXNZ-h8o7v07nvwE0Vrw-hFduD6IBgnOeO4GkC6AZV3IXgwYultK_2PIFiMoYoxMTEmJjgXf6GKUf9sq9_XLejd0DbFoX-z6cNw5MqCF0FZ6BRo60FFoZ39f8EvTheIPw</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Doillon, Charles J.</creator><creator>Wasserman, Arthur J.</creator><creator>Berg, Richard A.</creator><creator>Silver, Frederick H.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Behaviour of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix</title><author>Doillon, Charles J. ; Wasserman, Arthur J. ; Berg, Richard A. ; Silver, Frederick H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c3102af905ccde41d87f75fb5ecd39eec12567cfd6e08c1bdf7b4c3038149bd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cells, Cultured</topic><topic>Chick Embryo</topic><topic>Collagen</topic><topic>Epidermal Cells</topic><topic>Epidermis - drug effects</topic><topic>Extracellular Matrix</topic><topic>fibroblasts</topic><topic>Fibroblasts - cytology</topic><topic>Fibroblasts - drug effects</topic><topic>fibronectin</topic><topic>Fibronectins - pharmacology</topic><topic>Glycoproteins</topic><topic>Glycosaminoglycans</topic><topic>Guinea Pigs</topic><topic>hyaluronic acid</topic><topic>Hyaluronic Acid - pharmacology</topic><topic>Microscopy, Electron</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Doillon, Charles J.</creatorcontrib><creatorcontrib>Wasserman, Arthur J.</creatorcontrib><creatorcontrib>Berg, Richard A.</creatorcontrib><creatorcontrib>Silver, Frederick H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Doillon, Charles J.</au><au>Wasserman, Arthur J.</au><au>Berg, Richard A.</au><au>Silver, Frederick H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behaviour of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1988</date><risdate>1988</risdate><volume>9</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>A porous collagen sponge can be used for supporting epidermal cells and fibroblasts in order to manufacture an artificial skin. 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| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 1988, Vol.9 (1), p.91-96 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biocompatible Materials Cell Differentiation Cell Division Cells, Cultured Chick Embryo Collagen Epidermal Cells Epidermis - drug effects Extracellular Matrix fibroblasts Fibroblasts - cytology Fibroblasts - drug effects fibronectin Fibronectins - pharmacology Glycoproteins Glycosaminoglycans Guinea Pigs hyaluronic acid Hyaluronic Acid - pharmacology Microscopy, Electron |
| title | Behaviour of fibroblasts and epidermal cells cultivated on analogues of extracellular matrix |
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