Repression of the insulin receptor promoter by the tumor suppressor gene product p53 : A possible mechanism for receptor overexpression in breast cancer

There is strong evidence to suggest that insulin and insulin-like growth factor (IGF)-I may be important for tumor growth. Both the insulin and IGF-I receptors (IGF-IR) are overexpressed in breast cancer, and antibody blockade of the IGF-IR inhibits the growth of some breast cancer cell lines. Furth...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-06, Vol.56 (12), p.2781-2788
Hauptverfasser:	WEBSTER, N. J. G, RESNIK, J. L, REICHART, D. B, STRAUSS, B, HAAS, M, SEELY, B. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding, Competitive Biological and medical sciences Breast Neoplasms - metabolism CCAAT-Enhancer-Binding Proteins DNA-Binding Proteins - metabolism Female Genes, Reporter Gynecology. Andrology. Obstetrics Humans Insulin - metabolism Insulin-Like Growth Factor I - metabolism Mammary gland diseases Medical sciences Mice Molecular Sequence Data Nuclear Proteins - metabolism Promoter Regions, Genetic Receptor, IGF Type 1 - metabolism Receptor, Insulin - genetics Receptor, Insulin - metabolism Sp1 Transcription Factor - metabolism Transfection Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology Tumors
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