Endothelium-dependent relaxation in estrogen-treated spontaneously hypertensive rats

Female spontaneously hypertensive rats (SHR) were injected subcutaneously with mestranol twice a week for 12 weeks. Isolated segments of thoracic aorta were then used to generate relaxation response curves to acetylcholine or ATP after precontraction with phenylephrine. Estrogen treatment attenuated...

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Veröffentlicht in:	European journal of pharmacology 1988-01, Vol.145 (2), p.205-207
Hauptverfasser:	Williams, Shannon P., Paul Shackelford, D., Gregory Iams, S., Jamal Mustafa, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - pharmacology Adenosine Triphosphate - pharmacology Animals ATP Endothelium Endothelium, Vascular - drug effects Estrogen Female Hypertension Hypertension - drug therapy Hypertension - physiopathology Mestranol - pharmacology Muscle Contraction - drug effects Muscle Relaxation - drug effects Rats Rats, Inbred SHR Smooth muscle relaxation
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