Adenoviral-Mediated Herpes Simplex Virus-Thymidine Kinase Gene Transfer in Vivo for Treatment of Experimental Human Melanoma

To assess the efficacy of an in vivo adenoviral-mediated cytotoxic gene therapy, human melanomas were established in nude mice and transduced with herpes simplex virus-thymidine kinase (tk) followed by treatment with ganciclovir (GCV). In initial experiments, adenovirus (adv) containing the β-galact...

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Veröffentlicht in:	Journal of investigative dermatology 1996-06, Vol.106 (6), p.1163-1168
Hauptverfasser:	Bonnekoh, Bernd, Greenhalgh, David A., Bundman, Donnie S., Kosai, Ken-ichiro, Chen, Shu-Hsia, Finegold, Milton J., Krieg, Thomas, Woo, Savio L.C., Roop, Dennis R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics adenovirus Animals beta-Galactosidase - genetics cancer Cell Division - drug effects Ganciclovir - therapeutic use gene therapy Gene Transfer Techniques Genes, Reporter Genetic Vectors Humans Injections, Intraperitoneal Melanoma - drug therapy Melanoma - pathology Melanoma - therapy Mice Mice, Nude nude mice Simplexvirus - enzymology Thymidine Kinase - genetics Transduction, Genetic Tumor Cells, Cultured
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