Solution Structure of a Two-Base DNA Bulge Complexed with an Enediyne Cleaving Analog

Nucleic acid bulges have been implicated in a number of biological processes and are specific cleavage targets for the enediyne antitumor antibiotic neocarzinostatin chromophore in a base-catalyzed, radical-mediated reaction. The solution structure of the complex between an analog of the bulge-speci...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-06, Vol.272 (5270), p.1943-1946
Hauptverfasser:	Stassinopoulos, Adonis, Ji, Jie, Gao, Xiaolian, Goldberg, Irving H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibiotics Base Composition Base Sequence Biochemistry Biological and medical sciences Chemical bases Deoxyribonucleic acid DNA DNA - chemistry DNA - metabolism Dna, deoxyribonucleoproteins Enediynes Fundamental and applied biological sciences. Psychology Geometric Concepts Geometry Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Molecules NMR Nuclear magnetic resonance Nucleic Acid Conformation Nucleic acids Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Pharmaceutical microbiology Protons Solvents Spectroscopy Sugars Zinostatin - analogs & derivatives Zinostatin - chemistry Zinostatin - metabolism
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