Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver
A potent glycogenic effect for GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and the specific receptors detected for GLP-1(7-36)amide in these tissue membranes do not seem to be associated to adenylate cyclase. On the other hand, inositolphosphoglycan molecules (IPGs) have...
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| Veröffentlicht in: | Journal of endocrinological investigation 1996-02, Vol.19 (2), p.114-118 |
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| container_title | Journal of endocrinological investigation |
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| creator | TRAPOTE, M. A CLEMENTE, F GALERA, C MORALES, M ALCANTARA, A. I LOPEZ-DELGADO, M. I VILLANUEVA-PENACARRILLO, M. L VALVERDE, I |
| description | A potent glycogenic effect for GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and the specific receptors detected for GLP-1(7-36)amide in these tissue membranes do not seem to be associated to adenylate cyclase. On the other hand, inositolphosphoglycan molecules (IPGs) have been implicated as second messengers in the action of insulin. In a human hepatoma cell line (HEP G-2), we have observed the presence of [125I]GLP-1(7-36)amide specific binding, and a stimulatory effect of the peptide upon glycogen synthesis, confirming the findings in isolated rat hepatocytes. Also, GLP-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (GPIs), in the same manner as insulin, indicating hydrolysis of GPIs and an immediate and short-lived generation of IPGs. Thus, IPGs could be mediators in the GLP-1(7-36)amide glycogenic action in the liver. |
| doi_str_mv | 10.1007/BF03349846 |
| format | Article |
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A ; CLEMENTE, F ; GALERA, C ; MORALES, M ; ALCANTARA, A. I ; LOPEZ-DELGADO, M. I ; VILLANUEVA-PENACARRILLO, M. L ; VALVERDE, I</creator><creatorcontrib>TRAPOTE, M. A ; CLEMENTE, F ; GALERA, C ; MORALES, M ; ALCANTARA, A. I ; LOPEZ-DELGADO, M. I ; VILLANUEVA-PENACARRILLO, M. L ; VALVERDE, I</creatorcontrib><description>A potent glycogenic effect for GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and the specific receptors detected for GLP-1(7-36)amide in these tissue membranes do not seem to be associated to adenylate cyclase. On the other hand, inositolphosphoglycan molecules (IPGs) have been implicated as second messengers in the action of insulin. In a human hepatoma cell line (HEP G-2), we have observed the presence of [125I]GLP-1(7-36)amide specific binding, and a stimulatory effect of the peptide upon glycogen synthesis, confirming the findings in isolated rat hepatocytes. Also, GLP-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (GPIs), in the same manner as insulin, indicating hydrolysis of GPIs and an immediate and short-lived generation of IPGs. Thus, IPGs could be mediators in the GLP-1(7-36)amide glycogenic action in the liver.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03349846</identifier><identifier>PMID: 8778163</identifier><identifier>CODEN: JEIND7</identifier><language>eng</language><publisher>Milano: Kurtis</publisher><subject>Animals ; Biological and medical sciences ; Cell Line, Transformed ; Digestive system ; Glucagon ; Glucagon-Like Peptide 1 ; Glucagon-Like Peptides ; Glucose - metabolism ; Glycogen - biosynthesis ; Glycogen Synthase - metabolism ; Glycosylphosphatidylinositols - metabolism ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Liver - drug effects ; Liver - metabolism ; Medical sciences ; Neurotransmitter Agents - pharmacology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Peptide Fragments - pharmacology ; Rats</subject><ispartof>Journal of endocrinological investigation, 1996-02, Vol.19 (2), p.114-118</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-97bdbf1ef7ae0397044eac6d2462f938d7db35f4e858dfbb67771fff11b3f6cc3</citedby><cites>FETCH-LOGICAL-c311t-97bdbf1ef7ae0397044eac6d2462f938d7db35f4e858dfbb67771fff11b3f6cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3033325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8778163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TRAPOTE, M. A</creatorcontrib><creatorcontrib>CLEMENTE, F</creatorcontrib><creatorcontrib>GALERA, C</creatorcontrib><creatorcontrib>MORALES, M</creatorcontrib><creatorcontrib>ALCANTARA, A. I</creatorcontrib><creatorcontrib>LOPEZ-DELGADO, M. I</creatorcontrib><creatorcontrib>VILLANUEVA-PENACARRILLO, M. L</creatorcontrib><creatorcontrib>VALVERDE, I</creatorcontrib><title>Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>A potent glycogenic effect for GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and the specific receptors detected for GLP-1(7-36)amide in these tissue membranes do not seem to be associated to adenylate cyclase. On the other hand, inositolphosphoglycan molecules (IPGs) have been implicated as second messengers in the action of insulin. In a human hepatoma cell line (HEP G-2), we have observed the presence of [125I]GLP-1(7-36)amide specific binding, and a stimulatory effect of the peptide upon glycogen synthesis, confirming the findings in isolated rat hepatocytes. Also, GLP-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (GPIs), in the same manner as insulin, indicating hydrolysis of GPIs and an immediate and short-lived generation of IPGs. Thus, IPGs could be mediators in the GLP-1(7-36)amide glycogenic action in the liver.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Transformed</subject><subject>Digestive system</subject><subject>Glucagon</subject><subject>Glucagon-Like Peptide 1</subject><subject>Glucagon-Like Peptides</subject><subject>Glucose - metabolism</subject><subject>Glycogen - biosynthesis</subject><subject>Glycogen Synthase - metabolism</subject><subject>Glycosylphosphatidylinositols - metabolism</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Medical sciences</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Peptide Fragments - pharmacology</subject><subject>Rats</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMFLwzAUxoMoc04v3oUcRFSoJn1dkx51OB0MvOi5pGmyRbOmJq2w_97MFT08Ho_v9z74PoTOKbmjhLD7xzkByAqe5QdoTFlKEg48P0RjAgVNMlKwY3QSwgchwICzERpxxjjNYYzsonHBdM62axfirOxWiiZg4RVuXQimsgpvVG1E53zATuNurfDK9lKsXJNY8xk51XamVpjia5ZAfiM2u0vIzrgGm-b3w5pv5U_RkRY2qLNhT9D7_Olt9pIsX58Xs4dlIoHSLilYVVeaKs2EigkYyTIlZF6nWZ7qAnjN6gqmOlN8ymtdVTljjGqtKa1A51LCBF3tfVvvvnoVunJjglTWika5PpQxO0BBsgje7kHpY1avdNl6sxF-W1JS7qot_6uN8MXg2lexkT906DLql4MughRWe9FIE_4wiEaQTuEHqrSBFg</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>TRAPOTE, M. A</creator><creator>CLEMENTE, F</creator><creator>GALERA, C</creator><creator>MORALES, M</creator><creator>ALCANTARA, A. I</creator><creator>LOPEZ-DELGADO, M. I</creator><creator>VILLANUEVA-PENACARRILLO, M. L</creator><creator>VALVERDE, I</creator><general>Kurtis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver</title><author>TRAPOTE, M. A ; CLEMENTE, F ; GALERA, C ; MORALES, M ; ALCANTARA, A. I ; LOPEZ-DELGADO, M. I ; VILLANUEVA-PENACARRILLO, M. L ; VALVERDE, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-97bdbf1ef7ae0397044eac6d2462f938d7db35f4e858dfbb67771fff11b3f6cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Transformed</topic><topic>Digestive system</topic><topic>Glucagon</topic><topic>Glucagon-Like Peptide 1</topic><topic>Glucagon-Like Peptides</topic><topic>Glucose - metabolism</topic><topic>Glycogen - biosynthesis</topic><topic>Glycogen Synthase - metabolism</topic><topic>Glycosylphosphatidylinositols - metabolism</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Medical sciences</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Peptide Fragments - pharmacology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TRAPOTE, M. A</creatorcontrib><creatorcontrib>CLEMENTE, F</creatorcontrib><creatorcontrib>GALERA, C</creatorcontrib><creatorcontrib>MORALES, M</creatorcontrib><creatorcontrib>ALCANTARA, A. I</creatorcontrib><creatorcontrib>LOPEZ-DELGADO, M. I</creatorcontrib><creatorcontrib>VILLANUEVA-PENACARRILLO, M. L</creatorcontrib><creatorcontrib>VALVERDE, I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TRAPOTE, M. A</au><au>CLEMENTE, F</au><au>GALERA, C</au><au>MORALES, M</au><au>ALCANTARA, A. I</au><au>LOPEZ-DELGADO, M. I</au><au>VILLANUEVA-PENACARRILLO, M. L</au><au>VALVERDE, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>19</volume><issue>2</issue><spage>114</spage><epage>118</epage><pages>114-118</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><coden>JEIND7</coden><abstract>A potent glycogenic effect for GLP-1(7-36)amide has been found in rat hepatocytes and skeletal muscle, and the specific receptors detected for GLP-1(7-36)amide in these tissue membranes do not seem to be associated to adenylate cyclase. On the other hand, inositolphosphoglycan molecules (IPGs) have been implicated as second messengers in the action of insulin. In a human hepatoma cell line (HEP G-2), we have observed the presence of [125I]GLP-1(7-36)amide specific binding, and a stimulatory effect of the peptide upon glycogen synthesis, confirming the findings in isolated rat hepatocytes. Also, GLP-1(7-36)amide modulates the cell content of radiolabelled glycosylphosphatidylinositols (GPIs), in the same manner as insulin, indicating hydrolysis of GPIs and an immediate and short-lived generation of IPGs. Thus, IPGs could be mediators in the GLP-1(7-36)amide glycogenic action in the liver.</abstract><cop>Milano</cop><pub>Kurtis</pub><pmid>8778163</pmid><doi>10.1007/BF03349846</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0391-4097 |
| ispartof | Journal of endocrinological investigation, 1996-02, Vol.19 (2), p.114-118 |
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| subjects | Animals Biological and medical sciences Cell Line, Transformed Digestive system Glucagon Glucagon-Like Peptide 1 Glucagon-Like Peptides Glucose - metabolism Glycogen - biosynthesis Glycogen Synthase - metabolism Glycosylphosphatidylinositols - metabolism Humans Investigative techniques, diagnostic techniques (general aspects) Liver - drug effects Liver - metabolism Medical sciences Neurotransmitter Agents - pharmacology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peptide Fragments - pharmacology Rats |
| title | Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver |
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