Corpus Albicans-Like Structures in the Gonads in Androgen Insensitivity Syndrome
SUMMARYThe complete androgen insensitivity syndrome is the most common form of male pseudohermaphroditism and is due to end-organ unresponsiveness to androgens. The patients are phenotypically female, but the genotype is 46,XY, and the gonads are testicles, However, the common presence of Sertoli ce...
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| Veröffentlicht in: | International journal of gynecological pathology 1996-04, Vol.15 (2), p.177-180 |
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| container_title | International journal of gynecological pathology |
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| creator | Siegler, Richard W Beecham, Jackson B Schned, Alan R |
| description | SUMMARYThe complete androgen insensitivity syndrome is the most common form of male pseudohermaphroditism and is due to end-organ unresponsiveness to androgens. The patients are phenotypically female, but the genotype is 46,XY, and the gonads are testicles, However, the common presence of Sertoli cell adenomalike nodules of immature seminiferous tubules and the frequent presence of stroma resembling ovarian stroma may cause confusion about the nature of the gonad. Herein, we report the occurrence in such a gonad of corpus albicans-like structures, which resulted from progressive hyalinization and aggregation of immature tubules. These structures, which to our knowledge have not been previously described, must be recognized for what they represent to avoid misinterpretation in the pathologic evaluation of this disorder. |
| doi_str_mv | 10.1097/00004347-199604000-00014 |
| format | Article |
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The patients are phenotypically female, but the genotype is 46,XY, and the gonads are testicles, However, the common presence of Sertoli cell adenomalike nodules of immature seminiferous tubules and the frequent presence of stroma resembling ovarian stroma may cause confusion about the nature of the gonad. Herein, we report the occurrence in such a gonad of corpus albicans-like structures, which resulted from progressive hyalinization and aggregation of immature tubules. These structures, which to our knowledge have not been previously described, must be recognized for what they represent to avoid misinterpretation in the pathologic evaluation of this disorder.</description><identifier>ISSN: 0277-1691</identifier><identifier>EISSN: 1538-7151</identifier><identifier>DOI: 10.1097/00004347-199604000-00014</identifier><identifier>PMID: 8786209</identifier><identifier>CODEN: IJGPDR</identifier><language>eng</language><publisher>Philadelphia, PA: International Society of Gynecological Pathologists</publisher><subject>Adult ; Androgen-Insensitivity Syndrome - genetics ; Androgen-Insensitivity Syndrome - metabolism ; Androgen-Insensitivity Syndrome - pathology ; Androgens - metabolism ; Biological and medical sciences ; Disorders of Sex Development - genetics ; Disorders of Sex Development - metabolism ; Disorders of Sex Development - pathology ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance ; Medical sciences ; Phenotype ; Seminiferous Tubules - pathology ; Testis - pathology</subject><ispartof>International journal of gynecological pathology, 1996-04, Vol.15 (2), p.177-180</ispartof><rights>1996International Society of Gynecological Pathologists</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3054447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8786209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siegler, Richard W</creatorcontrib><creatorcontrib>Beecham, Jackson B</creatorcontrib><creatorcontrib>Schned, Alan R</creatorcontrib><title>Corpus Albicans-Like Structures in the Gonads in Androgen Insensitivity Syndrome</title><title>International journal of gynecological pathology</title><addtitle>Int J Gynecol Pathol</addtitle><description>SUMMARYThe complete androgen insensitivity syndrome is the most common form of male pseudohermaphroditism and is due to end-organ unresponsiveness to androgens. The patients are phenotypically female, but the genotype is 46,XY, and the gonads are testicles, However, the common presence of Sertoli cell adenomalike nodules of immature seminiferous tubules and the frequent presence of stroma resembling ovarian stroma may cause confusion about the nature of the gonad. Herein, we report the occurrence in such a gonad of corpus albicans-like structures, which resulted from progressive hyalinization and aggregation of immature tubules. These structures, which to our knowledge have not been previously described, must be recognized for what they represent to avoid misinterpretation in the pathologic evaluation of this disorder.</description><subject>Adult</subject><subject>Androgen-Insensitivity Syndrome - genetics</subject><subject>Androgen-Insensitivity Syndrome - metabolism</subject><subject>Androgen-Insensitivity Syndrome - pathology</subject><subject>Androgens - metabolism</subject><subject>Biological and medical sciences</subject><subject>Disorders of Sex Development - genetics</subject><subject>Disorders of Sex Development - metabolism</subject><subject>Disorders of Sex Development - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance</subject><subject>Medical sciences</subject><subject>Phenotype</subject><subject>Seminiferous Tubules - pathology</subject><subject>Testis - pathology</subject><issn>0277-1691</issn><issn>1538-7151</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtLAzEQgIMoWh8_QdiDeFvNa5PssRSthYKCeg7ZdNbGbrM12bX035va2puBEGbmm4T5glBG8B3BpbzHaXHGZU7KUmCeojxtwo_QgBRM5ZIU5BgNMJUJESU5Q-cxfiZCECFP0amSSlBcDtDLqA2rPmbDpnLW-JhP3QKy1y70tusDxMz5rJtDNm69mf1GQz8L7Qf4bOIj-Og69-26Tfa62eaXcIlOatNEuNqfF-j98eFt9JRPn8eT0XCaW0ZLnjNqhKFAmeGYWc55SYCKuhIYK1oUVmBqFFeyMrWFWsqSMVKRuki0sKwu2AW63d27Cu1XD7HTSxctNI3x0PZRS0UYU4InUO1AG9oYA9R6FdzShI0mWG9l6j-Z-iBT_8pMrdf7N_pqCbND495eqt_s6yZa09TBeOviAWO4SIPJhPEdtm6bDkJcNP0agp6Dabq5_u8r2Q-p7Yqd</recordid><startdate>199604</startdate><enddate>199604</enddate><creator>Siegler, Richard W</creator><creator>Beecham, Jackson B</creator><creator>Schned, Alan R</creator><general>International Society of Gynecological Pathologists</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199604</creationdate><title>Corpus Albicans-Like Structures in the Gonads in Androgen Insensitivity Syndrome</title><author>Siegler, Richard W ; Beecham, Jackson B ; Schned, Alan R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3294-32a6a2e23a403c44491e26fb6008255c602a8487bafcef779331b1f54036c3f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Androgen-Insensitivity Syndrome - genetics</topic><topic>Androgen-Insensitivity Syndrome - metabolism</topic><topic>Androgen-Insensitivity Syndrome - pathology</topic><topic>Androgens - metabolism</topic><topic>Biological and medical sciences</topic><topic>Disorders of Sex Development - genetics</topic><topic>Disorders of Sex Development - metabolism</topic><topic>Disorders of Sex Development - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance</topic><topic>Medical sciences</topic><topic>Phenotype</topic><topic>Seminiferous Tubules - pathology</topic><topic>Testis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siegler, Richard W</creatorcontrib><creatorcontrib>Beecham, Jackson B</creatorcontrib><creatorcontrib>Schned, Alan R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecological pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siegler, Richard W</au><au>Beecham, Jackson B</au><au>Schned, Alan R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corpus Albicans-Like Structures in the Gonads in Androgen Insensitivity Syndrome</atitle><jtitle>International journal of gynecological pathology</jtitle><addtitle>Int J Gynecol Pathol</addtitle><date>1996-04</date><risdate>1996</risdate><volume>15</volume><issue>2</issue><spage>177</spage><epage>180</epage><pages>177-180</pages><issn>0277-1691</issn><eissn>1538-7151</eissn><coden>IJGPDR</coden><abstract>SUMMARYThe complete androgen insensitivity syndrome is the most common form of male pseudohermaphroditism and is due to end-organ unresponsiveness to androgens. The patients are phenotypically female, but the genotype is 46,XY, and the gonads are testicles, However, the common presence of Sertoli cell adenomalike nodules of immature seminiferous tubules and the frequent presence of stroma resembling ovarian stroma may cause confusion about the nature of the gonad. Herein, we report the occurrence in such a gonad of corpus albicans-like structures, which resulted from progressive hyalinization and aggregation of immature tubules. These structures, which to our knowledge have not been previously described, must be recognized for what they represent to avoid misinterpretation in the pathologic evaluation of this disorder.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>International Society of Gynecological Pathologists</pub><pmid>8786209</pmid><doi>10.1097/00004347-199604000-00014</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0277-1691 |
| ispartof | International journal of gynecological pathology, 1996-04, Vol.15 (2), p.177-180 |
| issn | 0277-1691 1538-7151 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Androgen-Insensitivity Syndrome - genetics Androgen-Insensitivity Syndrome - metabolism Androgen-Insensitivity Syndrome - pathology Androgens - metabolism Biological and medical sciences Disorders of Sex Development - genetics Disorders of Sex Development - metabolism Disorders of Sex Development - pathology Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Male Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance Medical sciences Phenotype Seminiferous Tubules - pathology Testis - pathology |
| title | Corpus Albicans-Like Structures in the Gonads in Androgen Insensitivity Syndrome |
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