Locomotor response to novelty does not predict cocaine place preference conditioning in rats
Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psychostimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. In this report, we examined whether these high-responder (HR) ra...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1996, Vol.53 (1), p.191-196 |
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| container_end_page | 196 |
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| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 53 |
| creator | Gong, Wenhe Neill, Darryl B. Justice, Joseph B. |
| description | Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psychostimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. In this report, we examined whether these high-responder (HR) rats would develop place-preference conditioning with cocaine more readily than lowresponder (LR) rats. Neither group of rats developed conditioned place preference for cocaine, 2.5 mg/kg, intraperitoneally (IP). Both groups of rats developed conditioned place preference for cocaine, 5.0 and 15 mg/kg, IP. However, we could not find any evidence of enhanced conditioning in the HR rats. HR rats did show a greater locomotor response to cocaine, 15 mg/kg, IP, and the locomotor response of HR and LR rats to cocaine correlated with their response to a novel environment. We conclude that using the place-preference procedure, HR and LR rats do not differ in the rewarding effect of cocaine. |
| doi_str_mv | 10.1016/0091-3057(95)00174-3 |
| format | Article |
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In this report, we examined whether these high-responder (HR) rats would develop place-preference conditioning with cocaine more readily than lowresponder (LR) rats. Neither group of rats developed conditioned place preference for cocaine, 2.5 mg/kg, intraperitoneally (IP). Both groups of rats developed conditioned place preference for cocaine, 5.0 and 15 mg/kg, IP. However, we could not find any evidence of enhanced conditioning in the HR rats. HR rats did show a greater locomotor response to cocaine, 15 mg/kg, IP, and the locomotor response of HR and LR rats to cocaine correlated with their response to a novel environment. We conclude that using the place-preference procedure, HR and LR rats do not differ in the rewarding effect of cocaine.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(95)00174-3</identifier><identifier>PMID: 8848450</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Central Nervous System Stimulants - pharmacology ; Cocaine ; Cocaine - pharmacology ; Conditioned place preference ; Conditioning, Operant - drug effects ; Drug addictions ; Environment ; High responder ; Individual differences ; Injections, Intraperitoneal ; Locomotor activity ; Low responder ; Male ; Medical sciences ; Motor Activity - drug effects ; Novelty ; Rats ; Rats, Sprague-Dawley ; Reward ; Toxicology</subject><ispartof>Pharmacology, biochemistry and behavior, 1996, Vol.53 (1), p.191-196</ispartof><rights>1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e74d8f87ca095670167b5eee7dd74846bb7dfdb3efeaf882d756950e74639c213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0091305795001743$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2977308$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8848450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Wenhe</creatorcontrib><creatorcontrib>Neill, Darryl B.</creatorcontrib><creatorcontrib>Justice, Joseph B.</creatorcontrib><title>Locomotor response to novelty does not predict cocaine place preference conditioning in rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psychostimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. In this report, we examined whether these high-responder (HR) rats would develop place-preference conditioning with cocaine more readily than lowresponder (LR) rats. Neither group of rats developed conditioned place preference for cocaine, 2.5 mg/kg, intraperitoneally (IP). Both groups of rats developed conditioned place preference for cocaine, 5.0 and 15 mg/kg, IP. However, we could not find any evidence of enhanced conditioning in the HR rats. HR rats did show a greater locomotor response to cocaine, 15 mg/kg, IP, and the locomotor response of HR and LR rats to cocaine correlated with their response to a novel environment. We conclude that using the place-preference procedure, HR and LR rats do not differ in the rewarding effect of cocaine.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Conditioned place preference</subject><subject>Conditioning, Operant - drug effects</subject><subject>Drug addictions</subject><subject>Environment</subject><subject>High responder</subject><subject>Individual differences</subject><subject>Injections, Intraperitoneal</subject><subject>Locomotor activity</subject><subject>Low responder</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Motor Activity - drug effects</subject><subject>Novelty</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reward</subject><subject>Toxicology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtq3DAUQEVpSKdp_yAFLUpIF24ly_KVN4EQ0gcMZNPuCkKWroOKR3IlTSB_X7kzzLJd6XHPfR1CLjn7yBnvPzE28EYwCdeD_MAYh64RL8iGKxCN5AAvyeaEvCKvc_7FGOvaHs7JuVKd6iTbkJ_baOMulphowrzEkJGWSEN8wrk8Uxcx10ehS0LnbaE2WuMD0mU2FtffCROGerUxOF98DD48Uh9oMiW_IWeTmTO-PZ4X5Mfn--93X5vtw5dvd7fbxnYcSoPQOTUpsIYNsoe6G4wSEcE5qGP24whucqOovcykVOtA9oNkNa0Xg225uCBXh7pLir_3mIve-Wxxnk3AuM8aFBct9N1_Qd5XP1yqCnYH0KaYc91SL8nvTHrWnOnVvl7V6lWtHqT-a1-LmvbuWH8_7tCdko66a_z9MW6yNfOUTLA-n7B2ABBs7X5zwLBKe_KYdLZ-tex8Qlu0i_7fc_wBETqhXw</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Gong, Wenhe</creator><creator>Neill, Darryl B.</creator><creator>Justice, Joseph B.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Locomotor response to novelty does not predict cocaine place preference conditioning in rats</title><author>Gong, Wenhe ; Neill, Darryl B. ; Justice, Joseph B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e74d8f87ca095670167b5eee7dd74846bb7dfdb3efeaf882d756950e74639c213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Conditioned place preference</topic><topic>Conditioning, Operant - drug effects</topic><topic>Drug addictions</topic><topic>Environment</topic><topic>High responder</topic><topic>Individual differences</topic><topic>Injections, Intraperitoneal</topic><topic>Locomotor activity</topic><topic>Low responder</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Motor Activity - drug effects</topic><topic>Novelty</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reward</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gong, Wenhe</creatorcontrib><creatorcontrib>Neill, Darryl B.</creatorcontrib><creatorcontrib>Justice, Joseph B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gong, Wenhe</au><au>Neill, Darryl B.</au><au>Justice, Joseph B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Locomotor response to novelty does not predict cocaine place preference conditioning in rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1996</date><risdate>1996</risdate><volume>53</volume><issue>1</issue><spage>191</spage><epage>196</epage><pages>191-196</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Previous studies have demonstrated that rats showing a strong locomotor response to a novel environment have a greater locomotor response to psychostimulant drugs and more rapidly acquire intravenous self-administration of amphetamine. 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| ispartof | Pharmacology, biochemistry and behavior, 1996, Vol.53 (1), p.191-196 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Central Nervous System Stimulants - pharmacology Cocaine Cocaine - pharmacology Conditioned place preference Conditioning, Operant - drug effects Drug addictions Environment High responder Individual differences Injections, Intraperitoneal Locomotor activity Low responder Male Medical sciences Motor Activity - drug effects Novelty Rats Rats, Sprague-Dawley Reward Toxicology |
| title | Locomotor response to novelty does not predict cocaine place preference conditioning in rats |
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