Experimental thrombolysis of thromboembolisms in the middle cerebral artery circulatory area
Since the majority of ischaemic cerebral infarcts is caused by thromboemboli, we determined the benefit of fibrinolytic therapy in acute stroke. Thromboemboli were induced in the middle cerebral artery of 21 dogs. Urokinase was started at different time intervals after infarction (1, 3 and 5 hours)...
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| Veröffentlicht in: | RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren 1988-02, Vol.148 (2), p.117-120 |
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| container_title | RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren |
| container_volume | 148 |
| creator | Hirschberg, M Wiesmann, W Korves, M Koc, I Hofferberth, B |
| description | Since the majority of ischaemic cerebral infarcts is caused by thromboemboli, we determined the benefit of fibrinolytic therapy in acute stroke. Thromboemboli were induced in the middle cerebral artery of 21 dogs. Urokinase was started at different time intervals after infarction (1, 3 and 5 hours) at a rate of 1000 IU/kg/min. Angiographically controlled thrombolysis was achieved in all 15 treated cases, whereas in the control group (n = 6) no case of recanalisation was observed. Systemic fibrinolysis occurred in all cases. Postmortem examinations of the brains showed no intracerebral haemorrhages. Our findings indicate that urokinase treatment may be of value in acute ischaemic stroke. |
| format | Article |
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Thromboemboli were induced in the middle cerebral artery of 21 dogs. Urokinase was started at different time intervals after infarction (1, 3 and 5 hours) at a rate of 1000 IU/kg/min. Angiographically controlled thrombolysis was achieved in all 15 treated cases, whereas in the control group (n = 6) no case of recanalisation was observed. Systemic fibrinolysis occurred in all cases. Postmortem examinations of the brains showed no intracerebral haemorrhages. 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Our findings indicate that urokinase treatment may be of value in acute ischaemic stroke.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Cerebral Arteries - pathology</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical</subject><subject>Intracranial Embolism and Thrombosis - drug therapy</subject><subject>Intracranial Embolism and Thrombosis - pathology</subject><subject>Ischemic Attack, Transient - drug therapy</subject><subject>Ischemic Attack, Transient - pathology</subject><subject>Time Factors</subject><subject>Urokinase-Type Plasminogen Activator - administration & dosage</subject><issn>1438-9029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE9LxDAQxXNQ1nX1Iwg5eSukTbJpjrKsf2BhL3sUyiSZYiRpa9KC_fZWrKc378ebgXlXZFsKXheaVfqG3Ob8yZhgJdcbsqlqXkrFtuT9-D1g8hG7EQIdP1IfTR_m7DPt23-Pv8znmKnvFoY0eucCUosJTVr2II2YZmp9slOAsV9mSAh35LqFkPF-1R25PB8vh9fidH55OzydikFyVkhrWYtaGGUApXaADKxrteaoGSojhNtbbirZslYbJqBW-wWUXEpUznK-I49_Z4fUf02Yxyb6bDEE6LCfcqPqkpe1UEvwYQ1OJqJrhuVxSHOztsF_AF4KXU0</recordid><startdate>198802</startdate><enddate>198802</enddate><creator>Hirschberg, M</creator><creator>Wiesmann, W</creator><creator>Korves, M</creator><creator>Koc, I</creator><creator>Hofferberth, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198802</creationdate><title>Experimental thrombolysis of thromboembolisms in the middle cerebral artery circulatory area</title><author>Hirschberg, M ; Wiesmann, W ; Korves, M ; Koc, I ; Hofferberth, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p530-5cc0fe94b7bae59dae0acdf993e90e7b44d6c3b25f0f9b04a8766c31355e7dc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>1988</creationdate><topic>Acute Disease</topic><topic>Animals</topic><topic>Cerebral Arteries - pathology</topic><topic>Dogs</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical</topic><topic>Intracranial Embolism and Thrombosis - drug therapy</topic><topic>Intracranial Embolism and Thrombosis - pathology</topic><topic>Ischemic Attack, Transient - drug therapy</topic><topic>Ischemic Attack, Transient - pathology</topic><topic>Time Factors</topic><topic>Urokinase-Type Plasminogen Activator - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirschberg, M</creatorcontrib><creatorcontrib>Wiesmann, W</creatorcontrib><creatorcontrib>Korves, M</creatorcontrib><creatorcontrib>Koc, I</creatorcontrib><creatorcontrib>Hofferberth, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirschberg, M</au><au>Wiesmann, W</au><au>Korves, M</au><au>Koc, I</au><au>Hofferberth, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental thrombolysis of thromboembolisms in the middle cerebral artery circulatory area</atitle><jtitle>RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren</jtitle><addtitle>Rofo</addtitle><date>1988-02</date><risdate>1988</risdate><volume>148</volume><issue>2</issue><spage>117</spage><epage>120</epage><pages>117-120</pages><issn>1438-9029</issn><abstract>Since the majority of ischaemic cerebral infarcts is caused by thromboemboli, we determined the benefit of fibrinolytic therapy in acute stroke. Thromboemboli were induced in the middle cerebral artery of 21 dogs. Urokinase was started at different time intervals after infarction (1, 3 and 5 hours) at a rate of 1000 IU/kg/min. Angiographically controlled thrombolysis was achieved in all 15 treated cases, whereas in the control group (n = 6) no case of recanalisation was observed. Systemic fibrinolysis occurred in all cases. Postmortem examinations of the brains showed no intracerebral haemorrhages. Our findings indicate that urokinase treatment may be of value in acute ischaemic stroke.</abstract><cop>Germany</cop><pmid>2831570</pmid><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1438-9029 |
| ispartof | RöFo : Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebende Verfahren, 1988-02, Vol.148 (2), p.117-120 |
| issn | 1438-9029 |
| language | ger |
| recordid | cdi_proquest_miscellaneous_78131847 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Acute Disease Animals Cerebral Arteries - pathology Dogs Dose-Response Relationship, Drug Drug Evaluation, Preclinical Intracranial Embolism and Thrombosis - drug therapy Intracranial Embolism and Thrombosis - pathology Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - pathology Time Factors Urokinase-Type Plasminogen Activator - administration & dosage |
| title | Experimental thrombolysis of thromboembolisms in the middle cerebral artery circulatory area |
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