Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression
Normal cells have limited proliferative potential in culture, a fact that has been the basis of their use as a model for replicative senescence for many years. Recent molecular analyses have identified numerous changes in gene expression that occur as cells become senescent, and the results indicate...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-07, Vol.273 (5271), p.63-67 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 67 |
|---|---|
| container_issue | 5271 |
| container_start_page | 63 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 273 |
| creator | Smith, James R. Pereira-Smith, Olivia M. |
| description | Normal cells have limited proliferative potential in culture, a fact that has been the basis of their use as a model for replicative senescence for many years. Recent molecular analyses have identified numerous changes in gene expression that occur as cells become senescent, and the results indicate that multiple levels of control contribute to the irreversible growth arrest. These include repression of growth stimulatory genes, overexpression of growth inhibitory genes, and interference with downstream pathways. Studies with cell types other than fibroblasts will better define the role of cell senescence in the aging process and in tumorigenesis. |
| doi_str_mv | 10.1126/science.273.5271.63 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_78131607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A18500992</galeid><jstor_id>2890039</jstor_id><sourcerecordid>A18500992</sourcerecordid><originalsourceid>FETCH-LOGICAL-c746t-e825e77c2f7e5b84ada88e050fab534a4d2a4627cf5d283baea545ca2f57be5d3</originalsourceid><addsrcrecordid>eNqN012L00AUBuAgylpXf4EKwQv1wtT5yGQm3tWitVAs2HVvh8nkJExJMtmZZNF_75SG1ZWylFwEznnmkJy8iaKXGM0xJtlHrw10GuaE0zkjHM8z-iiaYZSzJCeIPo5mCNEsEYizp9Ez7_cIhV5OL6ILkTGBcz6LNj-gb4xWg7mFeAcdeH2Y-Slet1Pddj6urItNF1-bWxsvatPVserK-GpsQ3039r0D7wN8Hj2pVOPhxXS_jH5-_XK1_JZstqv1crFJNE-zIQFBGHCuScWBFSJVpRICEEOVKhhNVVoSlWaE64qVRNBCgWIp04pUjBfASnoZvT3O7Z29GcEPsjXhuZtGdWBHL7nAFGeIB_juYZjSlNCc4iDf_Cf3dnRdeAtJMGWMkgz9RbVqQJqusoNT-jBSLrBgYbs5CejDCVSH1TrV2A4qE8r_8uQED1cJrdGn_Pt7PpABfg21Gr2X6933s-n2-mz6eXUuFavNA6uYqLZNAzXIkInl9h6nR66d9d5BJXtnWuV-S4zkIfFySrwMiZeHxMuMhlOvpy83Fi2Ud2emiIf-q2N_7wfr7tpE5OHvyOkf5VsBBw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213553260</pqid></control><display><type>article</type><title>Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Smith, James R. ; Pereira-Smith, Olivia M.</creator><creatorcontrib>Smith, James R. ; Pereira-Smith, Olivia M.</creatorcontrib><description>Normal cells have limited proliferative potential in culture, a fact that has been the basis of their use as a model for replicative senescence for many years. Recent molecular analyses have identified numerous changes in gene expression that occur as cells become senescent, and the results indicate that multiple levels of control contribute to the irreversible growth arrest. These include repression of growth stimulatory genes, overexpression of growth inhibitory genes, and interference with downstream pathways. Studies with cell types other than fibroblasts will better define the role of cell senescence in the aging process and in tumorigenesis.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.273.5271.63</identifier><identifier>PMID: 8658197</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Society for the Advancement of Science</publisher><subject>Aging ; Aging (Biology) ; Aging - genetics ; Animals ; Cell culture techniques ; Cell cycle ; Cell Division - genetics ; Cell growth ; Cell lines ; Cellular biology ; Cellular senescence ; Cellular Senescence - genetics ; Epithelial cells ; Fibroblasts ; Gene Expression ; Genes ; Genes, Tumor Suppressor ; Genetic aspects ; Genetic Disorders ; Genetics ; Horizons in Aging ; Humans ; Individualized Instruction ; Molecular biology ; Neoplasms - etiology ; Neoplasms - genetics ; Somatic cells ; T lymphocytes ; Telomerase - metabolism ; Telomere - metabolism ; Tumor suppressor genes ; Tumors ; Tumour suppressor genes</subject><ispartof>Science (American Association for the Advancement of Science), 1996-07, Vol.273 (5271), p.63-67</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jul 5, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c746t-e825e77c2f7e5b84ada88e050fab534a4d2a4627cf5d283baea545ca2f57be5d3</citedby><cites>FETCH-LOGICAL-c746t-e825e77c2f7e5b84ada88e050fab534a4d2a4627cf5d283baea545ca2f57be5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2890039$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2890039$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8658197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, James R.</creatorcontrib><creatorcontrib>Pereira-Smith, Olivia M.</creatorcontrib><title>Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Normal cells have limited proliferative potential in culture, a fact that has been the basis of their use as a model for replicative senescence for many years. Recent molecular analyses have identified numerous changes in gene expression that occur as cells become senescent, and the results indicate that multiple levels of control contribute to the irreversible growth arrest. These include repression of growth stimulatory genes, overexpression of growth inhibitory genes, and interference with downstream pathways. Studies with cell types other than fibroblasts will better define the role of cell senescence in the aging process and in tumorigenesis.</description><subject>Aging</subject><subject>Aging (Biology)</subject><subject>Aging - genetics</subject><subject>Animals</subject><subject>Cell culture techniques</subject><subject>Cell cycle</subject><subject>Cell Division - genetics</subject><subject>Cell growth</subject><subject>Cell lines</subject><subject>Cellular biology</subject><subject>Cellular senescence</subject><subject>Cellular Senescence - genetics</subject><subject>Epithelial cells</subject><subject>Fibroblasts</subject><subject>Gene Expression</subject><subject>Genes</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic aspects</subject><subject>Genetic Disorders</subject><subject>Genetics</subject><subject>Horizons in Aging</subject><subject>Humans</subject><subject>Individualized Instruction</subject><subject>Molecular biology</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - genetics</subject><subject>Somatic cells</subject><subject>T lymphocytes</subject><subject>Telomerase - metabolism</subject><subject>Telomere - metabolism</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><subject>Tumour suppressor genes</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN012L00AUBuAgylpXf4EKwQv1wtT5yGQm3tWitVAs2HVvh8nkJExJMtmZZNF_75SG1ZWylFwEznnmkJy8iaKXGM0xJtlHrw10GuaE0zkjHM8z-iiaYZSzJCeIPo5mCNEsEYizp9Ez7_cIhV5OL6ILkTGBcz6LNj-gb4xWg7mFeAcdeH2Y-Slet1Pddj6urItNF1-bWxsvatPVserK-GpsQ3039r0D7wN8Hj2pVOPhxXS_jH5-_XK1_JZstqv1crFJNE-zIQFBGHCuScWBFSJVpRICEEOVKhhNVVoSlWaE64qVRNBCgWIp04pUjBfASnoZvT3O7Z29GcEPsjXhuZtGdWBHL7nAFGeIB_juYZjSlNCc4iDf_Cf3dnRdeAtJMGWMkgz9RbVqQJqusoNT-jBSLrBgYbs5CejDCVSH1TrV2A4qE8r_8uQED1cJrdGn_Pt7PpABfg21Gr2X6933s-n2-mz6eXUuFavNA6uYqLZNAzXIkInl9h6nR66d9d5BJXtnWuV-S4zkIfFySrwMiZeHxMuMhlOvpy83Fi2Ud2emiIf-q2N_7wfr7tpE5OHvyOkf5VsBBw</recordid><startdate>19960705</startdate><enddate>19960705</enddate><creator>Smith, James R.</creator><creator>Pereira-Smith, Olivia M.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19960705</creationdate><title>Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression</title><author>Smith, James R. ; Pereira-Smith, Olivia M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c746t-e825e77c2f7e5b84ada88e050fab534a4d2a4627cf5d283baea545ca2f57be5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aging</topic><topic>Aging (Biology)</topic><topic>Aging - genetics</topic><topic>Animals</topic><topic>Cell culture techniques</topic><topic>Cell cycle</topic><topic>Cell Division - genetics</topic><topic>Cell growth</topic><topic>Cell lines</topic><topic>Cellular biology</topic><topic>Cellular senescence</topic><topic>Cellular Senescence - genetics</topic><topic>Epithelial cells</topic><topic>Fibroblasts</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Genes, Tumor Suppressor</topic><topic>Genetic aspects</topic><topic>Genetic Disorders</topic><topic>Genetics</topic><topic>Horizons in Aging</topic><topic>Humans</topic><topic>Individualized Instruction</topic><topic>Molecular biology</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - genetics</topic><topic>Somatic cells</topic><topic>T lymphocytes</topic><topic>Telomerase - metabolism</topic><topic>Telomere - metabolism</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><topic>Tumour suppressor genes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, James R.</creatorcontrib><creatorcontrib>Pereira-Smith, Olivia M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, James R.</au><au>Pereira-Smith, Olivia M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1996-07-05</date><risdate>1996</risdate><volume>273</volume><issue>5271</issue><spage>63</spage><epage>67</epage><pages>63-67</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Normal cells have limited proliferative potential in culture, a fact that has been the basis of their use as a model for replicative senescence for many years. Recent molecular analyses have identified numerous changes in gene expression that occur as cells become senescent, and the results indicate that multiple levels of control contribute to the irreversible growth arrest. These include repression of growth stimulatory genes, overexpression of growth inhibitory genes, and interference with downstream pathways. Studies with cell types other than fibroblasts will better define the role of cell senescence in the aging process and in tumorigenesis.</abstract><cop>United States</cop><pub>American Society for the Advancement of Science</pub><pmid>8658197</pmid><doi>10.1126/science.273.5271.63</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-07, Vol.273 (5271), p.63-67 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78131607 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Aging Aging (Biology) Aging - genetics Animals Cell culture techniques Cell cycle Cell Division - genetics Cell growth Cell lines Cellular biology Cellular senescence Cellular Senescence - genetics Epithelial cells Fibroblasts Gene Expression Genes Genes, Tumor Suppressor Genetic aspects Genetic Disorders Genetics Horizons in Aging Humans Individualized Instruction Molecular biology Neoplasms - etiology Neoplasms - genetics Somatic cells T lymphocytes Telomerase - metabolism Telomere - metabolism Tumor suppressor genes Tumors Tumour suppressor genes |
| title | Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T16%3A46%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Replicative%20Senescence:%20Implications%20for%20in%20Vivo%20Aging%20and%20Tumor%20Suppression&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Smith,%20James%20R.&rft.date=1996-07-05&rft.volume=273&rft.issue=5271&rft.spage=63&rft.epage=67&rft.pages=63-67&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.273.5271.63&rft_dat=%3Cgale_proqu%3EA18500992%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213553260&rft_id=info:pmid/8658197&rft_galeid=A18500992&rft_jstor_id=2890039&rfr_iscdi=true |