The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

Cysteine proteases related to mammalian interleukin-1β converting enzyme (ICE) and to its Caenorhabditis elegans homologue, CED-3, play a critical role in the biochemical events that culminate in apoptosis. We have determined the three-dimensional structure of a complex of the human CED-3 homologue...

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Veröffentlicht in:	Nature Structural Biology 1996-07, Vol.3 (7), p.619-625
Hauptverfasser:	Rotonda, Jennifer, Nicholson, Donald W., Fazil, Kimberly M., Gallant, Michel, Gareau, Yves, Labelle, Marc, Peterson, Erin P., Rasper, Dita M., Ruel, Réjean, Vaillancourt, John P., Thornberry, Nancy A., Becker, Joseph W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis - physiology Biochemistry Biological Microscopy Biomedical and Life Sciences Caspase 3 Caspases Catalysis Crystallography, X-Ray Cysteine Endopeptidases - chemistry Enzyme Precursors - chemistry Humans Hydrogen Bonding Isoenzymes - chemistry Life Sciences Membrane Biology Models, Structural Molecular Sequence Data Protein Conformation Protein Structure Protein Structure, Tertiary Substrate Specificity
Online-Zugang:	Volltext
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