Effects of baclofen and phaclofen on receptive field properties of rat whisker barrel neurons

Extracellular single-unit recordings were made in somatosensory cortical barrels of fentanyl-sedated rats. Whiskers were deflected singly or in paired combinations. lontophoretically-applied (−)-baclofen disproportionately reduced weak responses, and phaclofen disproportionately increased them, resu...

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Veröffentlicht in:	Brain research 1996-03, Vol.712 (2), p.325-328
Hauptverfasser:	Kyriazi, Harold T., Carvell, George E., Brumberg, Joshua C., Simons, Daniel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baclofen - analogs & derivatives Baclofen - pharmacology Biological and medical sciences Cortex Extracellular Space - physiology Female Fundamental and applied biological sciences. Psychology GABA Agonists - pharmacology GABA Antagonists - pharmacology Inhibition Iontophoresis Mechanoreceptors - drug effects Mechanoreceptors - physiology Microiontophoresis Neurons, Afferent - drug effects Neurons, Afferent - physiology Rats Rats, Sprague-Dawley Somatosensory Somatosensory Cortex - drug effects Somatosensory Cortex - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Space life sciences Vertebrates: nervous system and sense organs Vibrissae - drug effects Vibrissae - physiology γ-Aminobutyric acid
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