Characterization of the sulfonylurea receptor on beta cell membranes

Specific, high affinity sulfonylurea receptors were characterized on membranes of an insulin-secreting hamster beta cell line (HIT cells). Saturable binding of the sulfonylurea, [3H]glyburide, was linear up to 0.8 mg/ml membrane protein. Scatchard analysis of equilibrium binding data at room tempera...

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Veröffentlicht in:	The Journal of biological chemistry 1988-02, Vol.263 (6), p.2589-2592
Hauptverfasser:	Gaines, K L, Hamilton, S, Boyd, A E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters Biological and medical sciences Cell Line Cell Membrane - metabolism Cell receptors Cell structures and functions Cricetinae Fundamental and applied biological sciences. Psychology Glipizide - pharmacology Glyburide - metabolism Insulin - metabolism islets of Langerhans Islets of Langerhans - metabolism Kinetics Molecular and cellular biology Potassium Channels Potassium Channels, Inwardly Rectifying Receptors, Drug - metabolism Sulfonylurea Compounds - metabolism Sulfonylurea Receptors sulfonylureas Temperature Tolazamide - pharmacology Tolbutamide - pharmacology
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