Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting
In this randomized, double-blind, parallel group, placebo-controlled, dose-ranging study, we have compared three doses (0.1 mg, 1.0 mg and 3.0 mg) of the 5-HT3 receptor antagonist, granisetron (Kytril), as prophylactic therapy for the prevention of postoperative nausea and vomiting. The aims were to...
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| Veröffentlicht in: | British Journal of Anaesthesia 1996-04, Vol.76 (4), p.515-518 |
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| container_title | British Journal of Anaesthesia |
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| creator | Wilson, A J Diemunsch, P Lindeque, B G Scheinin, H Helbo-Hansen, H S Kroeks, M V Kong, K L |
| description | In this randomized, double-blind, parallel group, placebo-controlled, dose-ranging study, we have compared three doses (0.1 mg, 1.0 mg and 3.0 mg) of the 5-HT3 receptor antagonist, granisetron (Kytril), as prophylactic therapy for the prevention of postoperative nausea and vomiting. The aims were to determine the optimal dose of granisetron and to evaluate its safety profile. We studied 527 adult patients, undergoing elective open abdominal surgery or vaginal hysterectomy during general anaesthesia. Antiemetic prophylaxis with a single dose of granisetron 1.0 mg or 3.0 mg resulted in a significant reduction (P < 0.001 compared with placebo) in the numbers of patients experiencing postoperative vomiting, or nausea, or who achieved total control during the postoperative periods 0-6 h and 0-24 h. The two higher doses of granisetron (1.0 mg and 3.0 mg) provided effective prophylaxis against vomiting, with 78% and 77% of patients, respectively, being free from vomiting in the first 6 h after surgery, and 63% and 62% in the first 24 h. This compares with 50% and 34% at 0-6 h and 0-24 h, respectively, in the placebo group. Granisetron was well tolerated and the optimum dose was 1.0 mg. |
| doi_str_mv | 10.1093/bja/76.4.515 |
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The aims were to determine the optimal dose of granisetron and to evaluate its safety profile. We studied 527 adult patients, undergoing elective open abdominal surgery or vaginal hysterectomy during general anaesthesia. Antiemetic prophylaxis with a single dose of granisetron 1.0 mg or 3.0 mg resulted in a significant reduction (P < 0.001 compared with placebo) in the numbers of patients experiencing postoperative vomiting, or nausea, or who achieved total control during the postoperative periods 0-6 h and 0-24 h. The two higher doses of granisetron (1.0 mg and 3.0 mg) provided effective prophylaxis against vomiting, with 78% and 77% of patients, respectively, being free from vomiting in the first 6 h after surgery, and 63% and 62% in the first 24 h. This compares with 50% and 34% at 0-6 h and 0-24 h, respectively, in the placebo group. Granisetron was well tolerated and the optimum dose was 1.0 mg.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/76.4.515</identifier><identifier>PMID: 8652323</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anesthesia, General ; Antiemetics - administration & dosage ; Biological and medical sciences ; Digestive system ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; Granisetron - administration & dosage ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Middle Aged ; Nausea - etiology ; Nausea - prevention & control ; Pharmacology. Drug treatments ; Postoperative Complications - prevention & control ; Preanesthetic Medication ; Risk Factors ; Vomiting - etiology ; Vomiting - prevention & control</subject><ispartof>British Journal of Anaesthesia, 1996-04, Vol.76 (4), p.515-518</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright British Medical Association Apr 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-60ec998224c550abac572239d9a7af781b9620867c7d7ba8333b0ae0fd4d8f353</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23928,23929,25138,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3034938$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8652323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, A J</creatorcontrib><creatorcontrib>Diemunsch, P</creatorcontrib><creatorcontrib>Lindeque, B G</creatorcontrib><creatorcontrib>Scheinin, H</creatorcontrib><creatorcontrib>Helbo-Hansen, H S</creatorcontrib><creatorcontrib>Kroeks, M V</creatorcontrib><creatorcontrib>Kong, K L</creatorcontrib><title>Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting</title><title>British Journal of Anaesthesia</title><addtitle>Br J Anaesth</addtitle><addtitle>Br J Anaesth</addtitle><description>In this randomized, double-blind, parallel group, placebo-controlled, dose-ranging study, we have compared three doses (0.1 mg, 1.0 mg and 3.0 mg) of the 5-HT3 receptor antagonist, granisetron (Kytril), as prophylactic therapy for the prevention of postoperative nausea and vomiting. The aims were to determine the optimal dose of granisetron and to evaluate its safety profile. We studied 527 adult patients, undergoing elective open abdominal surgery or vaginal hysterectomy during general anaesthesia. Antiemetic prophylaxis with a single dose of granisetron 1.0 mg or 3.0 mg resulted in a significant reduction (P < 0.001 compared with placebo) in the numbers of patients experiencing postoperative vomiting, or nausea, or who achieved total control during the postoperative periods 0-6 h and 0-24 h. The two higher doses of granisetron (1.0 mg and 3.0 mg) provided effective prophylaxis against vomiting, with 78% and 77% of patients, respectively, being free from vomiting in the first 6 h after surgery, and 63% and 62% in the first 24 h. This compares with 50% and 34% at 0-6 h and 0-24 h, respectively, in the placebo group. Granisetron was well tolerated and the optimum dose was 1.0 mg.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia, General</subject><subject>Antiemetics - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Granisetron - administration & dosage</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nausea - etiology</subject><subject>Nausea - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Postoperative Complications - prevention & control</subject><subject>Preanesthetic Medication</subject><subject>Risk Factors</subject><subject>Vomiting - etiology</subject><subject>Vomiting - prevention & control</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUhoNY6rV151YYRHTjTPMxSSbLUvyCQhet65BJztRc5iZjkhnw3xu5ly5EcBXI--TNOQ9CrwnuCFbsatybKym6vuOEP0M70kvSCinJc7TDGMsWK0JfoJc57zEmkip-js4HwSmjbIfu7314nKF1MUPju61rHpMJPkNJMTQ-NOUHNEuCDULx9SZOzRJziQskU_wGTTBrBtOY4JotHnypdZfobDJzhlen8wJ9__zp4eZre3v35dvN9W1re65KKzBYpQZKe8s5NqOxXFLKlFNGmkkOZFSC4kFIK50czcAYG7EBPLneDRPj7AK9P_YuKf5cIRd98NnCPJsAcc26VtQlpajg27_AfVxTqLNpoqRUVSOu0McjZFPMOcGkl-QPJv3SBOs_onUVraXQva6iK_7m1LmOB3BP8Mlszd-dcpOtmadq1fr8hDHMesWGin04YnFd_vehOJJQlW4eks7WQ7DgfAJbtIv-3w9_A8JLpFQ</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Wilson, A J</creator><creator>Diemunsch, P</creator><creator>Lindeque, B G</creator><creator>Scheinin, H</creator><creator>Helbo-Hansen, H S</creator><creator>Kroeks, M V</creator><creator>Kong, K L</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting</title><author>Wilson, A J ; Diemunsch, P ; Lindeque, B G ; Scheinin, H ; Helbo-Hansen, H S ; Kroeks, M V ; Kong, K L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-60ec998224c550abac572239d9a7af781b9620867c7d7ba8333b0ae0fd4d8f353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia, General</topic><topic>Antiemetics - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Granisetron - administration & dosage</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nausea - etiology</topic><topic>Nausea - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Postoperative Complications - prevention & control</topic><topic>Preanesthetic Medication</topic><topic>Risk Factors</topic><topic>Vomiting - etiology</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilson, A J</creatorcontrib><creatorcontrib>Diemunsch, P</creatorcontrib><creatorcontrib>Lindeque, B G</creatorcontrib><creatorcontrib>Scheinin, H</creatorcontrib><creatorcontrib>Helbo-Hansen, H S</creatorcontrib><creatorcontrib>Kroeks, M V</creatorcontrib><creatorcontrib>Kong, K L</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>British Journal of Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilson, A J</au><au>Diemunsch, P</au><au>Lindeque, B G</au><au>Scheinin, H</au><au>Helbo-Hansen, H S</au><au>Kroeks, M V</au><au>Kong, K L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting</atitle><jtitle>British Journal of Anaesthesia</jtitle><stitle>Br J Anaesth</stitle><addtitle>Br J Anaesth</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>76</volume><issue>4</issue><spage>515</spage><epage>518</epage><pages>515-518</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>In this randomized, double-blind, parallel group, placebo-controlled, dose-ranging study, we have compared three doses (0.1 mg, 1.0 mg and 3.0 mg) of the 5-HT3 receptor antagonist, granisetron (Kytril), as prophylactic therapy for the prevention of postoperative nausea and vomiting. The aims were to determine the optimal dose of granisetron and to evaluate its safety profile. We studied 527 adult patients, undergoing elective open abdominal surgery or vaginal hysterectomy during general anaesthesia. Antiemetic prophylaxis with a single dose of granisetron 1.0 mg or 3.0 mg resulted in a significant reduction (P < 0.001 compared with placebo) in the numbers of patients experiencing postoperative vomiting, or nausea, or who achieved total control during the postoperative periods 0-6 h and 0-24 h. The two higher doses of granisetron (1.0 mg and 3.0 mg) provided effective prophylaxis against vomiting, with 78% and 77% of patients, respectively, being free from vomiting in the first 6 h after surgery, and 63% and 62% in the first 24 h. This compares with 50% and 34% at 0-6 h and 0-24 h, respectively, in the placebo group. 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| subjects | Adult Aged Aged, 80 and over Anesthesia, General Antiemetics - administration & dosage Biological and medical sciences Digestive system Dose-Response Relationship, Drug Double-Blind Method Female Granisetron - administration & dosage Humans Injections, Intravenous Male Medical sciences Middle Aged Nausea - etiology Nausea - prevention & control Pharmacology. Drug treatments Postoperative Complications - prevention & control Preanesthetic Medication Risk Factors Vomiting - etiology Vomiting - prevention & control |
| title | Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting |
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