Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction

The effect of nitroprusside in limiting myocardial infarct was compared with that of pinacidil, a new antihypertensive agent with potent coronary vasodilator properties, in instrumented awake dogs subjected to 4 hr of left anterior descending coronary artery occlusion and 20 hr of reperfusion. Dogs...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1988-03, Vol.77 (3), p.705-711
Hauptverfasser:	IMAI, N, LIANG, C.-S, STONE, C. K, SAKAMOTO, S, HOOD, W. B. JR
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Cardiovascular system Consciousness Coronary Circulation - drug effects Coronary Vessels - drug effects Dogs Ferricyanides - therapeutic use Guanidines - therapeutic use Medical sciences Myocardial Infarction - drug therapy Nitroprusside - therapeutic use Pharmacology. Drug treatments Pinacidil Random Allocation Vasodilator Agents - therapeutic use
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