Prolonged Calpain-mediated Spectrin Breakdown Occurs Regionally Following Experimental Brain Injury in the Rat

Calpain, a calcium-activated neutral protease family, has been implicated in the neuropathologic sequelae accompanying various neurological disorders. We have characterized the distribution and time course of calpain activation following brain injury in the rat, using a monoclonal antibody that reco...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 1996-07, Vol.55 (7), p.850-850
Hauptverfasser:	Saatman, Kathryn E, Bozyczko-Coyne, Donna, Marcy, Val, Siman, Robert, McIntosh, Tracy K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological products Blotting, Western Brain - metabolism Brain injuries Brain Injuries - metabolism Calpain Calpain - metabolism Enzyme Activation Immunohistochemistry Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Membrane proteins Monoclonal antibodies Rabbits Rats Rats, Sprague-Dawley Spectrin - metabolism Time Factors Tissue Distribution Traumas. Diseases due to physical agents
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