Alternative Structures in Duplex DNA Formed within the Trinucleotide Repeats of the Myotonic Dystrophy and Fragile X Loci

Most models proposed to explain the disease-associated expansion of (CTG) n ·(CAG) n and (CGG) n ·(CCG) n trinucleotide repeats include the formation of slipped strand DNA structures during replication; however, physical evidence for these alternative DNA secondary structures has not been reported....

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Veröffentlicht in:	Biochemistry (Easton) 1996-04, Vol.35 (15), p.5041-5053
Hauptverfasser:	Pearson, Christopher E., Sinden, Richard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence DNA - genetics Fragile X Syndrome - genetics Humans Models, Genetic Molecular Sequence Data Myotonic Dystrophy - genetics Nucleic Acid Conformation Restriction Mapping Trinucleotide Repeats
Online-Zugang:	Volltext
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