'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts
At a concentration of 0.5% (v/v), isoamyl alcohol induced the formation of hyphal-like extensions in haploid and diploid strains of Saccharomyces cerevisiae in liquid complex medium. These extensions, which develop via bud initiation and elongation, undergo DNA replication and nuclear division and a...
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| Veröffentlicht in: | Microbiology (Society for General Microbiology) 1996-06, Vol.142 (pt 6), p.1391-1397 |
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| container_title | Microbiology (Society for General Microbiology) |
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| creator | Dickinson, J.R |
| description | At a concentration of 0.5% (v/v), isoamyl alcohol induced the formation of hyphal-like extensions in haploid and diploid strains of Saccharomyces cerevisiae in liquid complex medium. These extensions, which develop via bud initiation and elongation, undergo DNA replication and nuclear division and appear similar in many respects to an aberrant form of the cell division cycle. However, in 0.25% (v/v) isoamyl alcohol, S. cerevisiae formed pseudohyphae. Other 'fusel' alcohols (which are the products of amino acid catabolism) also induced hyphal-like extensions in this yeast, with n-amyl alcohol being as equally effective as isoamyl alcohol. Isoamyl alcohol induced the formation of pseudohyphae in two species of Candida and both hyphal-like extensions and pseudohyphae in Brettanomyces anomalus, suggesting a close relationship or a common basis to the development of the two morphologies. |
| doi_str_mv | 10.1099/13500872-142-6-1391 |
| format | Article |
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These extensions, which develop via bud initiation and elongation, undergo DNA replication and nuclear division and appear similar in many respects to an aberrant form of the cell division cycle. However, in 0.25% (v/v) isoamyl alcohol, S. cerevisiae formed pseudohyphae. Other 'fusel' alcohols (which are the products of amino acid catabolism) also induced hyphal-like extensions in this yeast, with n-amyl alcohol being as equally effective as isoamyl alcohol. Isoamyl alcohol induced the formation of pseudohyphae in two species of Candida and both hyphal-like extensions and pseudohyphae in Brettanomyces anomalus, suggesting a close relationship or a common basis to the development of the two morphologies.</description><identifier>ISSN: 1350-0872</identifier><identifier>EISSN: 1465-2080</identifier><identifier>DOI: 10.1099/13500872-142-6-1391</identifier><identifier>PMID: 8704979</identifier><language>eng</language><publisher>Reading: Society for General Microbiology</publisher><subject>1-Propanol - pharmacology ; Alcohols - metabolism ; Alcohols - pharmacology ; Biological and medical sciences ; Butanols - pharmacology ; Cell Division ; DNA Replication ; DNA-Binding Proteins ; Ethanol - metabolism ; Ethanol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - metabolism ; Hexanols - pharmacology ; Isoleucine - metabolism ; Leucine - metabolism ; Methanol - pharmacology ; Microbiology ; Morphology, structure, chemical composition ; Mycology ; Nitrogen - metabolism ; Pentanols - pharmacology ; Phenylethyl Alcohol - pharmacology ; plant anatomy ; plant biochemistry ; plant morphology ; plant physiology ; Protein Kinases - metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - growth & development ; Saccharomyces cerevisiae - ultrastructure ; Saccharomyces cerevisiae Proteins ; Species Specificity ; Valine - metabolism ; Yeasts - drug effects ; Yeasts - metabolism</subject><ispartof>Microbiology (Society for General Microbiology), 1996-06, Vol.142 (pt 6), p.1391-1397</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3107526$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8704979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dickinson, J.R</creatorcontrib><title>'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts</title><title>Microbiology (Society for General Microbiology)</title><addtitle>Microbiology (Reading)</addtitle><description>At a concentration of 0.5% (v/v), isoamyl alcohol induced the formation of hyphal-like extensions in haploid and diploid strains of Saccharomyces cerevisiae in liquid complex medium. These extensions, which develop via bud initiation and elongation, undergo DNA replication and nuclear division and appear similar in many respects to an aberrant form of the cell division cycle. However, in 0.25% (v/v) isoamyl alcohol, S. cerevisiae formed pseudohyphae. Other 'fusel' alcohols (which are the products of amino acid catabolism) also induced hyphal-like extensions in this yeast, with n-amyl alcohol being as equally effective as isoamyl alcohol. Isoamyl alcohol induced the formation of pseudohyphae in two species of Candida and both hyphal-like extensions and pseudohyphae in Brettanomyces anomalus, suggesting a close relationship or a common basis to the development of the two morphologies.</description><subject>1-Propanol - pharmacology</subject><subject>Alcohols - metabolism</subject><subject>Alcohols - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Butanols - pharmacology</subject><subject>Cell Division</subject><subject>DNA Replication</subject><subject>DNA-Binding Proteins</subject><subject>Ethanol - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - metabolism</subject><subject>Hexanols - pharmacology</subject><subject>Isoleucine - metabolism</subject><subject>Leucine - metabolism</subject><subject>Methanol - pharmacology</subject><subject>Microbiology</subject><subject>Morphology, structure, chemical composition</subject><subject>Mycology</subject><subject>Nitrogen - metabolism</subject><subject>Pentanols - pharmacology</subject><subject>Phenylethyl Alcohol - pharmacology</subject><subject>plant anatomy</subject><subject>plant biochemistry</subject><subject>plant morphology</subject><subject>plant physiology</subject><subject>Protein Kinases - metabolism</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - drug effects</subject><subject>Saccharomyces cerevisiae - growth & development</subject><subject>Saccharomyces cerevisiae - ultrastructure</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Species Specificity</subject><subject>Valine - metabolism</subject><subject>Yeasts - drug effects</subject><subject>Yeasts - metabolism</subject><issn>1350-0872</issn><issn>1465-2080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E1P3DAQgGELFVG-fkFVkQOCk9sZO_46VggoElIPlHM0cexuwJts40Tq_nuMdsW1J4_0PjMHM_YF4RuCc99RKgBrBMdacM1ROjxgx1hrxQVY-FTmIvg7-cxOcn4BKBHwiB1ZA7Uz7pg9Xd8tOaTripIfV2PKVT90iw_VartZUeKpfw1V-DeHIffjkCsaumqTw9KNO1DFcVrTXFpZrLaB8pzP2GGklMP5_j1lz3e3v29-8sdf9w83Px55FA5mHshiRwaNDc5L2VrrrSGvfHQuRmdMrF2tQ1tbjZpkLYUgbUwLoBS2XZSn7Gp3dzONf5eQ52bdZx9SoiGMS26MRQG1gf9CVFoq1Fjg1z1c2nXoms3Ur2naNvvvKv1y3yl7SnGiwff5g0kEo4Qu7GLHIo0N_ZkKeX4SgBJQSQEO5BuST4KE</recordid><startdate>19960601</startdate><enddate>19960601</enddate><creator>Dickinson, J.R</creator><general>Society for General Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19960601</creationdate><title>'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts</title><author>Dickinson, J.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f290t-ea81da7178e9c33b88c87ac5cf99ff977f4946eb48616a34322a677b00551bdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>1-Propanol - pharmacology</topic><topic>Alcohols - metabolism</topic><topic>Alcohols - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Butanols - pharmacology</topic><topic>Cell Division</topic><topic>DNA Replication</topic><topic>DNA-Binding Proteins</topic><topic>Ethanol - metabolism</topic><topic>Ethanol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - metabolism</topic><topic>Hexanols - pharmacology</topic><topic>Isoleucine - metabolism</topic><topic>Leucine - metabolism</topic><topic>Methanol - pharmacology</topic><topic>Microbiology</topic><topic>Morphology, structure, chemical composition</topic><topic>Mycology</topic><topic>Nitrogen - metabolism</topic><topic>Pentanols - pharmacology</topic><topic>Phenylethyl Alcohol - pharmacology</topic><topic>plant anatomy</topic><topic>plant biochemistry</topic><topic>plant morphology</topic><topic>plant physiology</topic><topic>Protein Kinases - metabolism</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - drug effects</topic><topic>Saccharomyces cerevisiae - growth & development</topic><topic>Saccharomyces cerevisiae - ultrastructure</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Species Specificity</topic><topic>Valine - metabolism</topic><topic>Yeasts - drug effects</topic><topic>Yeasts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dickinson, J.R</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Microbiology (Society for General Microbiology)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dickinson, J.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts</atitle><jtitle>Microbiology (Society for General Microbiology)</jtitle><addtitle>Microbiology (Reading)</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>142</volume><issue>pt 6</issue><spage>1391</spage><epage>1397</epage><pages>1391-1397</pages><issn>1350-0872</issn><eissn>1465-2080</eissn><abstract>At a concentration of 0.5% (v/v), isoamyl alcohol induced the formation of hyphal-like extensions in haploid and diploid strains of Saccharomyces cerevisiae in liquid complex medium. These extensions, which develop via bud initiation and elongation, undergo DNA replication and nuclear division and appear similar in many respects to an aberrant form of the cell division cycle. However, in 0.25% (v/v) isoamyl alcohol, S. cerevisiae formed pseudohyphae. Other 'fusel' alcohols (which are the products of amino acid catabolism) also induced hyphal-like extensions in this yeast, with n-amyl alcohol being as equally effective as isoamyl alcohol. Isoamyl alcohol induced the formation of pseudohyphae in two species of Candida and both hyphal-like extensions and pseudohyphae in Brettanomyces anomalus, suggesting a close relationship or a common basis to the development of the two morphologies.</abstract><cop>Reading</cop><pub>Society for General Microbiology</pub><pmid>8704979</pmid><doi>10.1099/13500872-142-6-1391</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1350-0872 |
| ispartof | Microbiology (Society for General Microbiology), 1996-06, Vol.142 (pt 6), p.1391-1397 |
| issn | 1350-0872 1465-2080 |
| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | 1-Propanol - pharmacology Alcohols - metabolism Alcohols - pharmacology Biological and medical sciences Butanols - pharmacology Cell Division DNA Replication DNA-Binding Proteins Ethanol - metabolism Ethanol - pharmacology Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism Hexanols - pharmacology Isoleucine - metabolism Leucine - metabolism Methanol - pharmacology Microbiology Morphology, structure, chemical composition Mycology Nitrogen - metabolism Pentanols - pharmacology Phenylethyl Alcohol - pharmacology plant anatomy plant biochemistry plant morphology plant physiology Protein Kinases - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - ultrastructure Saccharomyces cerevisiae Proteins Species Specificity Valine - metabolism Yeasts - drug effects Yeasts - metabolism |
| title | 'Fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts |
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