Prolactin and testosterone: their role in male sexual function
Summary The role of androgens in the sexuality of men is still not completely clear. Men with severe hyperprolactinaemia frequently show mild hypogonadism, and many complain of loss of libido and penile erectile dysfunction (ED). We studied the night‐sleep related erections and the penile response t...
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| Veröffentlicht in: | International journal of andrology 1996-02, Vol.19 (1), p.48-54 |
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| container_title | International journal of andrology |
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| creator | CARANI, C. GRANATA, A. R. M. FUSTINI, M. FAUSTINI MARRAMA, P. |
| description | Summary
The role of androgens in the sexuality of men is still not completely clear. Men with severe hyperprolactinaemia frequently show mild hypogonadism, and many complain of loss of libido and penile erectile dysfunction (ED). We studied the night‐sleep related erections and the penile response to visual erotic stimuli (VES) in 44 men: 13 with severe hypogonadism (Group 1; serum testosterone |
| doi_str_mv | 10.1111/j.1365-2605.1996.tb00434.x |
| format | Article |
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The role of androgens in the sexuality of men is still not completely clear. Men with severe hyperprolactinaemia frequently show mild hypogonadism, and many complain of loss of libido and penile erectile dysfunction (ED). We studied the night‐sleep related erections and the penile response to visual erotic stimuli (VES) in 44 men: 13 with severe hypogonadism (Group 1; serum testosterone <1.4 ng/ml), 10 with mild hypogonadism (Group 2; serum testosterone 2–3.5 ng/ml), nine with severe hyperprolactinaemia and mild hypogonadism (Group 3) and 12 control men (Group 4). All of the patients complained of loss of libido and ED. Group 1 showed significantly impaired night erections when compared with any of the other three groups, but no differences were detected between Groups 2, 3 and 4. The penile response to VES did not show any significant difference between the four groups, but was lower in Group 1 than in Group 4. These data confirm that night erections are androgen‐dependent, but also suggest that there are two thresholds for serum testosterone: one below which sexual behaviour is impaired with normal night erections, and a lower threshold below which night erections are also impaired. The penile response to VES was confirmed as being only partially androgen‐independent. Furthermore hyperprolactinaemia does not affect night erections or the penile response to VES, suggesting that its effect on libido and sexual behaviour is due mainly to modulation of the psychological pattern of the patient.</description><identifier>ISSN: 0105-6263</identifier><identifier>EISSN: 1365-2605</identifier><identifier>DOI: 10.1111/j.1365-2605.1996.tb00434.x</identifier><identifier>PMID: 8698538</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Case-Control Studies ; Circadian Rhythm ; erotic stimuli ; Erotica ; Humans ; hyperprolactinaemia ; Hyperprolactinemia - blood ; hypogonadism ; Hypogonadism - blood ; Hypogonadism - physiopathology ; Male ; Middle Aged ; nocturnal penile erections ; Penile Erection - physiology ; Prolactin - blood ; Prolactin - physiology ; Sexual Behavior - physiology ; sexual behaviour ; Testosterone - blood ; Testosterone - deficiency ; Testosterone - physiology ; Time Factors</subject><ispartof>International journal of andrology, 1996-02, Vol.19 (1), p.48-54</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4368-2af07b20393ebf9ae82150376a116f76a64a92d9d373cf7d19a2158c3e239efe3</citedby><cites>FETCH-LOGICAL-c4368-2af07b20393ebf9ae82150376a116f76a64a92d9d373cf7d19a2158c3e239efe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2605.1996.tb00434.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2605.1996.tb00434.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8698538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CARANI, C.</creatorcontrib><creatorcontrib>GRANATA, A. R. M.</creatorcontrib><creatorcontrib>FUSTINI, M. FAUSTINI</creatorcontrib><creatorcontrib>MARRAMA, P.</creatorcontrib><title>Prolactin and testosterone: their role in male sexual function</title><title>International journal of andrology</title><addtitle>Int J Androl</addtitle><description>Summary
The role of androgens in the sexuality of men is still not completely clear. Men with severe hyperprolactinaemia frequently show mild hypogonadism, and many complain of loss of libido and penile erectile dysfunction (ED). We studied the night‐sleep related erections and the penile response to visual erotic stimuli (VES) in 44 men: 13 with severe hypogonadism (Group 1; serum testosterone <1.4 ng/ml), 10 with mild hypogonadism (Group 2; serum testosterone 2–3.5 ng/ml), nine with severe hyperprolactinaemia and mild hypogonadism (Group 3) and 12 control men (Group 4). All of the patients complained of loss of libido and ED. Group 1 showed significantly impaired night erections when compared with any of the other three groups, but no differences were detected between Groups 2, 3 and 4. The penile response to VES did not show any significant difference between the four groups, but was lower in Group 1 than in Group 4. These data confirm that night erections are androgen‐dependent, but also suggest that there are two thresholds for serum testosterone: one below which sexual behaviour is impaired with normal night erections, and a lower threshold below which night erections are also impaired. The penile response to VES was confirmed as being only partially androgen‐independent. Furthermore hyperprolactinaemia does not affect night erections or the penile response to VES, suggesting that its effect on libido and sexual behaviour is due mainly to modulation of the psychological pattern of the patient.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Circadian Rhythm</subject><subject>erotic stimuli</subject><subject>Erotica</subject><subject>Humans</subject><subject>hyperprolactinaemia</subject><subject>Hyperprolactinemia - blood</subject><subject>hypogonadism</subject><subject>Hypogonadism - blood</subject><subject>Hypogonadism - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>nocturnal penile erections</subject><subject>Penile Erection - physiology</subject><subject>Prolactin - blood</subject><subject>Prolactin - physiology</subject><subject>Sexual Behavior - physiology</subject><subject>sexual behaviour</subject><subject>Testosterone - blood</subject><subject>Testosterone - deficiency</subject><subject>Testosterone - physiology</subject><subject>Time Factors</subject><issn>0105-6263</issn><issn>1365-2605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9PwjAYxhujQUQ_gsniwdtm23frVg4khChCCHrQcGzK9i4Ox4btFuHb2wXC3V6ew_Onb36EPDAaMPeeNgEDEflc0ChgUoqgWVMaQhjsL0j_bF2SPmU08gUXcE1urN1QSiEB1iO9RMgkgqRPRu-mLnXaFJWnq8xr0Da1bdDUFQ695gsL47kAes7faqcW960uvbytXKeubslVrkuLdycdkM-X54_Jq794m84m44WfhiASn-ucxmtOQQKuc6kx4SyiEAvNmMidiFBLnskMYkjzOGNSu0CSAnKQmCMMyONxd2fqn9YdqbaFTbEsdYV1a1WcME5DDi44PAZTU1trMFc7U2y1OShGVQdPbVRHSHWEVAdPneCpvSvfn35p11vMztUTLeePjv5vUeLhH8tqNh8vw27APw4UjvH-PKDNtxIxxJFaLadqyldzKkAoAX8Tp41l</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>CARANI, C.</creator><creator>GRANATA, A. R. M.</creator><creator>FUSTINI, M. FAUSTINI</creator><creator>MARRAMA, P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199602</creationdate><title>Prolactin and testosterone: their role in male sexual function</title><author>CARANI, C. ; GRANATA, A. R. M. ; FUSTINI, M. FAUSTINI ; MARRAMA, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4368-2af07b20393ebf9ae82150376a116f76a64a92d9d373cf7d19a2158c3e239efe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Circadian Rhythm</topic><topic>erotic stimuli</topic><topic>Erotica</topic><topic>Humans</topic><topic>hyperprolactinaemia</topic><topic>Hyperprolactinemia - blood</topic><topic>hypogonadism</topic><topic>Hypogonadism - blood</topic><topic>Hypogonadism - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>nocturnal penile erections</topic><topic>Penile Erection - physiology</topic><topic>Prolactin - blood</topic><topic>Prolactin - physiology</topic><topic>Sexual Behavior - physiology</topic><topic>sexual behaviour</topic><topic>Testosterone - blood</topic><topic>Testosterone - deficiency</topic><topic>Testosterone - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARANI, C.</creatorcontrib><creatorcontrib>GRANATA, A. R. M.</creatorcontrib><creatorcontrib>FUSTINI, M. FAUSTINI</creatorcontrib><creatorcontrib>MARRAMA, P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of andrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CARANI, C.</au><au>GRANATA, A. R. M.</au><au>FUSTINI, M. FAUSTINI</au><au>MARRAMA, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolactin and testosterone: their role in male sexual function</atitle><jtitle>International journal of andrology</jtitle><addtitle>Int J Androl</addtitle><date>1996-02</date><risdate>1996</risdate><volume>19</volume><issue>1</issue><spage>48</spage><epage>54</epage><pages>48-54</pages><issn>0105-6263</issn><eissn>1365-2605</eissn><abstract>Summary
The role of androgens in the sexuality of men is still not completely clear. Men with severe hyperprolactinaemia frequently show mild hypogonadism, and many complain of loss of libido and penile erectile dysfunction (ED). We studied the night‐sleep related erections and the penile response to visual erotic stimuli (VES) in 44 men: 13 with severe hypogonadism (Group 1; serum testosterone <1.4 ng/ml), 10 with mild hypogonadism (Group 2; serum testosterone 2–3.5 ng/ml), nine with severe hyperprolactinaemia and mild hypogonadism (Group 3) and 12 control men (Group 4). All of the patients complained of loss of libido and ED. Group 1 showed significantly impaired night erections when compared with any of the other three groups, but no differences were detected between Groups 2, 3 and 4. The penile response to VES did not show any significant difference between the four groups, but was lower in Group 1 than in Group 4. These data confirm that night erections are androgen‐dependent, but also suggest that there are two thresholds for serum testosterone: one below which sexual behaviour is impaired with normal night erections, and a lower threshold below which night erections are also impaired. The penile response to VES was confirmed as being only partially androgen‐independent. Furthermore hyperprolactinaemia does not affect night erections or the penile response to VES, suggesting that its effect on libido and sexual behaviour is due mainly to modulation of the psychological pattern of the patient.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8698538</pmid><doi>10.1111/j.1365-2605.1996.tb00434.x</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Case-Control Studies Circadian Rhythm erotic stimuli Erotica Humans hyperprolactinaemia Hyperprolactinemia - blood hypogonadism Hypogonadism - blood Hypogonadism - physiopathology Male Middle Aged nocturnal penile erections Penile Erection - physiology Prolactin - blood Prolactin - physiology Sexual Behavior - physiology sexual behaviour Testosterone - blood Testosterone - deficiency Testosterone - physiology Time Factors |
| title | Prolactin and testosterone: their role in male sexual function |
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