MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp.—I. isolation, structural determination and biological properties of MS-271

A novel cyclic peptide, MS-271, was isolated from the culture broth of an actinomycete, Streptomyces sp. M-271 as an inhibitor of smooth muscle myosin light chain kinase (MLCK). MS-271 inhibited the MLCK from chicken gizzard with an IC 50, value of 8 μM. MS-271 did not inhibit cyclic AMP-dependent p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 1996, Vol.4 (1), p.115-120
Hauptverfasser:	Yano, Keiichi, Toki, Shinichiro, Nakanishi, Satoshi, Ochiai, Keiko, Ando, Katsuhiko, Yoshida, Mayumi, Matsuda, Yuzuru, Yamasaki, Motoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism AIDS/HIV Amino Acid Sequence Amino Acids - analysis Animals Anti-Bacterial Agents anti-HIV Antifungal Agents Cattle Chickens Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Fermentation inhibitor Microbial Sensitivity Tests Molecular Sequence Data Myosin light chain kinase Myosin-Light-Chain Kinase - antagonists & inhibitors Peptides, Cyclic - biosynthesis Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology primary structure Rats Streptomyces Streptomyces - chemistry Streptomyces - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!