Hepatocyte growth factor induces activation of Nck and phospholipase C-γ in lung carcinoma cells

Hepatocyte growth factor (HGF), a mesenchyme derived growth factor, promotes cell growth, cell motility, and morphogenesis in a variety of epithelial cells. The diverse responses are transduced across the cell membrane by the met/HGF receptor, a product of c-met protooncogene. The met/HGF receptor r...

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Veröffentlicht in:	Cancer letters 1996-07, Vol.104 (2), p.163-169
Hauptverfasser:	Kochhar, Kulvinder S., Iyer, Anand P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Biological and medical sciences Cell physiology Enzyme Activation Fundamental and applied biological sciences. Psychology Hepatocyte growth factor Hepatocyte Growth Factor - pharmacology Humans Lung Neoplasms - metabolism Met/HGF receptor Molecular and cellular biology Oncogene Proteins - drug effects Oncogene Proteins - metabolism Phosphorylation Proto-Oncogene Proteins c-met Receptor Protein-Tyrosine Kinases - metabolism Receptor-tyrosine kinase Responses to growth factors, tumor promotors, other factors Tumor Cells, Cultured Type C Phospholipases - drug effects Type C Phospholipases - metabolism Tyrosine phosphorylalion
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