(S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist
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| Veröffentlicht in: | Journal of medicinal chemistry 1996-06, Vol.39 (13), p.2435-2437 |
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| container_end_page | 2437 |
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| container_issue | 13 |
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| container_title | Journal of medicinal chemistry |
| container_volume | 39 |
| creator | TenBrink, Ruth E Bergh, Carol L Duncan, J. Neil Harris, Douglas W Huff, R. M Lahti, Robert A Lawson, Charles F Lutzke, Barry S Martin, Iain J Rees, Susan A Schlachter, Siusaidh K Sih, John C Smith, Martin W |
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| doi_str_mv | 10.1021/jm960084f |
| format | Article |
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Neil ; Harris, Douglas W ; Huff, R. M ; Lahti, Robert A ; Lawson, Charles F ; Lutzke, Barry S ; Martin, Iain J ; Rees, Susan A ; Schlachter, Siusaidh K ; Sih, John C ; Smith, Martin W</creator><creatorcontrib>TenBrink, Ruth E ; Bergh, Carol L ; Duncan, J. Neil ; Harris, Douglas W ; Huff, R. 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Drug treatments ; Piperazines - chemical synthesis ; Piperazines - chemistry ; Piperazines - metabolism ; Piperazines - pharmacology ; Protein Binding ; Quinpirole ; Receptors, Adrenergic - metabolism ; Receptors, Dopamine D4 ; Receptors, Serotonin - metabolism ; Schizophrenia - drug therapy ; Sulfonamides - chemical synthesis ; Sulfonamides - chemistry ; Sulfonamides - metabolism ; Sulfonamides - pharmacology</subject><ispartof>Journal of medicinal chemistry, 1996-06, Vol.39 (13), p.2435-2437</ispartof><rights>Copyright © 1996 American Chemical Society</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm960084f$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm960084f$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>315,782,786,27085,27933,27934,56747,56797</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3120107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8691438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TenBrink, Ruth E</creatorcontrib><creatorcontrib>Bergh, Carol L</creatorcontrib><creatorcontrib>Duncan, J. Neil</creatorcontrib><creatorcontrib>Harris, Douglas W</creatorcontrib><creatorcontrib>Huff, R. M</creatorcontrib><creatorcontrib>Lahti, Robert A</creatorcontrib><creatorcontrib>Lawson, Charles F</creatorcontrib><creatorcontrib>Lutzke, Barry S</creatorcontrib><creatorcontrib>Martin, Iain J</creatorcontrib><creatorcontrib>Rees, Susan A</creatorcontrib><creatorcontrib>Schlachter, Siusaidh K</creatorcontrib><creatorcontrib>Sih, John C</creatorcontrib><creatorcontrib>Smith, Martin W</creatorcontrib><title>(S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><subject>Animals</subject><subject>Antipsychotic Agents - chemical synthesis</subject><subject>Antipsychotic Agents - chemistry</subject><subject>Antipsychotic Agents - metabolism</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Catecholaminergic system</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Dopamine Agonists - pharmacology</subject><subject>Dopamine Antagonists - chemical synthesis</subject><subject>Dopamine Antagonists - chemistry</subject><subject>Dopamine Antagonists - metabolism</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Dopamine D2 Receptor Antagonists</subject><subject>Ergolines - antagonists & inhibitors</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperazines - chemical synthesis</subject><subject>Piperazines - chemistry</subject><subject>Piperazines - metabolism</subject><subject>Piperazines - pharmacology</subject><subject>Protein Binding</subject><subject>Quinpirole</subject><subject>Receptors, Adrenergic - metabolism</subject><subject>Receptors, Dopamine D4</subject><subject>Receptors, Serotonin - metabolism</subject><subject>Schizophrenia - drug therapy</subject><subject>Sulfonamides - chemical synthesis</subject><subject>Sulfonamides - chemistry</subject><subject>Sulfonamides - metabolism</subject><subject>Sulfonamides - pharmacology</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kdtqFEEQhhtR4iZ64QMIe6GyC7ZWn2cu48ZDMKCw0QslNDU9PWY2Mz3j9Iy4eQKvfUSfxA67LBRUUf9HUfUXIU8YvGLA2etNm2uATFb3yIwpDlRmIO-TGQDnlGsuHpLjGDcAIBgXR-Qo0zmTIpuRsFgv6eLfn79LKun3FJwuzmPnroeuxUAZ3TZLP15vm6u-7v2At_WueVX4cOuDj1NTdQHbuvQv5zhf-8a7sf7l52ddn7ohFXJ-Gkb80YU6jo_Igwqb6B_v8wn58u7t5eoDvfj0_nx1ekFRKD7SCrjiDh0r0FUoysIoCaZkSjmeucoIZwrlXJmZHEVuINdGOSkLnZc6L5wQJ-TFbm4_dD8nH0fb1tH5psHguylakzGWSQ0JfLoHp6L1pe2HusVha_cGJf3ZXsfosKkGDK6OByzZCQxMwugOSzf63wcZhxurjTDKXn5e29XH_Kt5803bu_2e73h00W66aQjJDcvA3r3THt4p_gPKHY3C</recordid><startdate>19960621</startdate><enddate>19960621</enddate><creator>TenBrink, Ruth E</creator><creator>Bergh, Carol L</creator><creator>Duncan, J. 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M ; Lahti, Robert A ; Lawson, Charles F ; Lutzke, Barry S ; Martin, Iain J ; Rees, Susan A ; Schlachter, Siusaidh K ; Sih, John C ; Smith, Martin W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a352t-f0252cac1bacfa3db75407d155c28cf73c7b5ccd879a39709675c44b69d69bc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antipsychotic Agents - chemical synthesis</topic><topic>Antipsychotic Agents - chemistry</topic><topic>Antipsychotic Agents - metabolism</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Catecholaminergic system</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Dopamine Agonists - pharmacology</topic><topic>Dopamine Antagonists - chemical synthesis</topic><topic>Dopamine Antagonists - chemistry</topic><topic>Dopamine Antagonists - metabolism</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine D2 Receptor Antagonists</topic><topic>Ergolines - antagonists & inhibitors</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperazines - chemical synthesis</topic><topic>Piperazines - chemistry</topic><topic>Piperazines - metabolism</topic><topic>Piperazines - pharmacology</topic><topic>Protein Binding</topic><topic>Quinpirole</topic><topic>Receptors, Adrenergic - metabolism</topic><topic>Receptors, Dopamine D4</topic><topic>Receptors, Serotonin - metabolism</topic><topic>Schizophrenia - drug therapy</topic><topic>Sulfonamides - chemical synthesis</topic><topic>Sulfonamides - chemistry</topic><topic>Sulfonamides - metabolism</topic><topic>Sulfonamides - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TenBrink, Ruth E</creatorcontrib><creatorcontrib>Bergh, Carol L</creatorcontrib><creatorcontrib>Duncan, J. Neil</creatorcontrib><creatorcontrib>Harris, Douglas W</creatorcontrib><creatorcontrib>Huff, R. 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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1996-06, Vol.39 (13), p.2435-2437 |
| issn | 0022-2623 1520-4804 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78118460 |
| source | MEDLINE; ACS Publications |
| subjects | Animals Antipsychotic Agents - chemical synthesis Antipsychotic Agents - chemistry Antipsychotic Agents - metabolism Antipsychotic Agents - pharmacology Biological and medical sciences Biological Availability Catecholaminergic system CHO Cells Cricetinae Dopamine Agonists - pharmacology Dopamine Antagonists - chemical synthesis Dopamine Antagonists - chemistry Dopamine Antagonists - metabolism Dopamine Antagonists - pharmacology Dopamine D2 Receptor Antagonists Ergolines - antagonists & inhibitors Humans Medical sciences Molecular Structure Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Piperazines - chemical synthesis Piperazines - chemistry Piperazines - metabolism Piperazines - pharmacology Protein Binding Quinpirole Receptors, Adrenergic - metabolism Receptors, Dopamine D4 Receptors, Serotonin - metabolism Schizophrenia - drug therapy Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - metabolism Sulfonamides - pharmacology |
| title | (S)-(−)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist |
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