Induction of phenazine biosynthesis in cultures of Pseudomonas aeruginosa by l-N-(3-oxohexanoyl) homoserine lactone

Abstract A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor l-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the production of phenazine metabolites was shown to...

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Veröffentlicht in:	FEMS microbiology letters 1996-06, Vol.140 (1), p.15-22
Hauptverfasser:	Stead, Paul, Rudd, Brian A.M., Bradshaw, Helen, Noble, David, Dawson, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - pharmacology Antibacterial agents Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antiinfectives and antibacterials Antimicrobial activity Applied microbiology Autoregulation Bacillus subtilis - drug effects Bacillus subtilis - metabolism Bacteria Biological and medical sciences Biology of microorganisms of confirmed or potential industrial interest Biosynthesis Biotechnology Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Escherichia coli - drug effects Escherichia coli - metabolism Fundamental and applied biological sciences. Psychology Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - metabolism Metabolites Microbial Sensitivity Tests Microbiological Techniques Microbiology Mission oriented research N‐(3‐Oxohexanoyl)homoserine lactone Phenazine Phenazines - metabolism Pheromones - pharmacology Physiology and metabolism Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - metabolism
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Zusammenfassung:	Abstract A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor l-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the production of phenazine metabolites was shown to be inducible in a dose-dependent manner. The production of phenazine-1-carboxamide increased over 50-fold compared to control cultures when supplemented with 200 µg/ml of the autoregulator. In addition, the production of an unidentified polar antibacterial substance by this strain increased with autoregulator concentration.
ISSN:	0378-1097 1574-6968
DOI:	10.1111/j.1574-6968.1996.tb08308.x