Cardiomyocyte troponin T immunoreactivity is modified by cross-linking resulting from intracellular calcium overload

During myocardial ischemia, the increase in cytosolic Ca2+ promotes the activation of neutral proteases such as calpains. Since the troponin T subunit is a substrate for calpains, we investigated the effects of irreversible myocyte damage on troponin T immunoreactivity. Hearts from adult guinea pigs...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1996-05, Vol.93 (10), p.1896-1904
Hauptverfasser:	GORZA, L, MENABO, R, VITADELLO, M, BERGAMINI, C. M, DI LISA, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood and lymphatic vessels Calcium - metabolism Calpain - physiology Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Guinea Pigs Immunohistochemistry Male Medical sciences Myocardial Ischemia - metabolism Myocardial Reperfusion Myocardium - chemistry Osmolar Concentration Transglutaminases - physiology Troponin - analysis Troponin - immunology Troponin T
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