Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea
In 15 patients with ventricular asystole of 8.5 ± 3.5 seconds (range 5.0 to 16.8) occurring exclusively during obstructive sleep apnea, electrophysiologic study of sinus node function and atrioventricular conduction before and after administration of intravenous atropine (0.02 mg/kg) was performed....
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| Veröffentlicht in: | The American journal of cardiology 1996-06, Vol.77 (15), p.1310-1314 |
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| container_title | The American journal of cardiology |
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| creator | Grimm, Wolfram Hoffmann, Jürgen Menz, Volker Köhler, Ulrich Heitmann, Jörg Peter, Jörg H. Maisch, Bernhard |
| description | In 15 patients with ventricular asystole of 8.5 ± 3.5 seconds (range 5.0 to 16.8) occurring exclusively during obstructive sleep apnea, electrophysiologic study of sinus node function and atrioventricular conduction before and after administration of intravenous atropine (0.02 mg/kg) was performed. Electrophysiologic parameters of sinus node function were normal in 12 of 15 patients (80%) and atrioventricular (AV) nodal function was normal in 7 patients (47%). Almost all abnormal findings of sinus node function and AV nodal function were reversible by administration of atropine. The HisPurkinje system function was normal in 6 patients (40%). Prolonged HV intervals (57 to 73 ms) were found in 9 patients (60%). Intra- or infra-His block was not observed in any patient. In summary, electrophysiologic parameters of sinus node function and AV conduction were normal or only slightly abnormal in all 15 study patients, which suggests that prolonged ventricular asystole during obstructive sleep apnea is not due to fixed or anatomic disease of the sinus node or the AV conduction system. |
| doi_str_mv | 10.1016/S0002-9149(96)00197-X |
| format | Article |
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Electrophysiologic parameters of sinus node function were normal in 12 of 15 patients (80%) and atrioventricular (AV) nodal function was normal in 7 patients (47%). Almost all abnormal findings of sinus node function and AV nodal function were reversible by administration of atropine. The HisPurkinje system function was normal in 6 patients (40%). Prolonged HV intervals (57 to 73 ms) were found in 9 patients (60%). Intra- or infra-His block was not observed in any patient. In summary, electrophysiologic parameters of sinus node function and AV conduction were normal or only slightly abnormal in all 15 study patients, which suggests that prolonged ventricular asystole during obstructive sleep apnea is not due to fixed or anatomic disease of the sinus node or the AV conduction system.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(96)00197-X</identifier><identifier>PMID: 8677871</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Atrioventricular Node - physiopathology ; Atropine ; Biological and medical sciences ; Cardiac Catheterization ; Cardiac Pacing, Artificial ; Cardiovascular disease ; Coronary vessels ; Electrocardiography, Ambulatory ; Female ; Heart ; Heart Arrest - diagnosis ; Heart Arrest - etiology ; Heart Arrest - physiopathology ; Heart Rate - drug effects ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; Polysomnography ; Positive-Pressure Respiration ; Sinoatrial Node - physiopathology ; Sleep Apnea Syndromes - complications ; Sleep Apnea Syndromes - physiopathology ; Sleep Apnea Syndromes - therapy ; Sleep disorders ; Time Factors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>The American journal of cardiology, 1996-06, Vol.77 (15), p.1310-1314</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. 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Electrophysiologic parameters of sinus node function were normal in 12 of 15 patients (80%) and atrioventricular (AV) nodal function was normal in 7 patients (47%). Almost all abnormal findings of sinus node function and AV nodal function were reversible by administration of atropine. The HisPurkinje system function was normal in 6 patients (40%). Prolonged HV intervals (57 to 73 ms) were found in 9 patients (60%). Intra- or infra-His block was not observed in any patient. In summary, electrophysiologic parameters of sinus node function and AV conduction were normal or only slightly abnormal in all 15 study patients, which suggests that prolonged ventricular asystole during obstructive sleep apnea is not due to fixed or anatomic disease of the sinus node or the AV conduction system.</description><subject>Atrioventricular Node - physiopathology</subject><subject>Atropine</subject><subject>Biological and medical sciences</subject><subject>Cardiac Catheterization</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Electrocardiography, Ambulatory</subject><subject>Female</subject><subject>Heart</subject><subject>Heart Arrest - diagnosis</subject><subject>Heart Arrest - etiology</subject><subject>Heart Arrest - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polysomnography</subject><subject>Positive-Pressure Respiration</subject><subject>Sinoatrial Node - physiopathology</subject><subject>Sleep Apnea Syndromes - complications</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sleep Apnea Syndromes - therapy</subject><subject>Sleep disorders</subject><subject>Time Factors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2KFDEQhYMo6-zqIywEEVkvWpPOdNK5WmRZf2DBCxX2LqST6tksmaRNOiPzPL6omR8G8carIjlfHarqIHRJyTtKKH__jRDSNpIu5ZXkbwmhUjT3T9CC9kI2VFL2FC1OyHN0nvNjfVLa8TN01nMhekEX6PetBzOnOD1ss4s-rpzBsNG-6NnFgOOIswsl4xAt4LEEs__WwWI9Jxc3EGoxxeuETQy2HHQX8FQNqpjxLzc_4ClV77ACi__u0Hmb5-gB25JcWOE45DntLDaAsweYsJ4C6Bfo2ah9hpfHeoF-fLz9fvO5ufv66cvNh7vGLCmfGyEHYTgRLeskh5brJYiW8o4ZbnnX05bxKgzadIMhoKkdmGZLC9xaKzor2QV6c_Ct0_4skGe1dtmA9zpALFmJfnc9wir46h_wMZYU6myqZYQtpRC8Qt0BMinmnGBUU3JrnbaKErVLUO0TVLt4lORqn6C6r32XR_MyrMGeuo6RVf31UdfZaD8mHYzLJ4xR1tdtK3Z9wKBebOMgqWxqIAasSzVxZaP7zyB_AOPOvTg</recordid><startdate>19960615</startdate><enddate>19960615</enddate><creator>Grimm, Wolfram</creator><creator>Hoffmann, Jürgen</creator><creator>Menz, Volker</creator><creator>Köhler, Ulrich</creator><creator>Heitmann, Jörg</creator><creator>Peter, Jörg H.</creator><creator>Maisch, Bernhard</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19960615</creationdate><title>Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea</title><author>Grimm, Wolfram ; Hoffmann, Jürgen ; Menz, Volker ; Köhler, Ulrich ; Heitmann, Jörg ; Peter, Jörg H. ; Maisch, Bernhard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-79b7c60723596e26a4e721653c6d6581236596bac5bc0ea1db3a34de6ddd75d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Atrioventricular Node - physiopathology</topic><topic>Atropine</topic><topic>Biological and medical sciences</topic><topic>Cardiac Catheterization</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Electrocardiography, Ambulatory</topic><topic>Female</topic><topic>Heart</topic><topic>Heart Arrest - diagnosis</topic><topic>Heart Arrest - etiology</topic><topic>Heart Arrest - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polysomnography</topic><topic>Positive-Pressure Respiration</topic><topic>Sinoatrial Node - physiopathology</topic><topic>Sleep Apnea Syndromes - complications</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><topic>Sleep Apnea Syndromes - therapy</topic><topic>Sleep disorders</topic><topic>Time Factors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grimm, Wolfram</creatorcontrib><creatorcontrib>Hoffmann, Jürgen</creatorcontrib><creatorcontrib>Menz, Volker</creatorcontrib><creatorcontrib>Köhler, Ulrich</creatorcontrib><creatorcontrib>Heitmann, Jörg</creatorcontrib><creatorcontrib>Peter, Jörg H.</creatorcontrib><creatorcontrib>Maisch, Bernhard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grimm, Wolfram</au><au>Hoffmann, Jürgen</au><au>Menz, Volker</au><au>Köhler, Ulrich</au><au>Heitmann, Jörg</au><au>Peter, Jörg H.</au><au>Maisch, Bernhard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1996-06-15</date><risdate>1996</risdate><volume>77</volume><issue>15</issue><spage>1310</spage><epage>1314</epage><pages>1310-1314</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>In 15 patients with ventricular asystole of 8.5 ± 3.5 seconds (range 5.0 to 16.8) occurring exclusively during obstructive sleep apnea, electrophysiologic study of sinus node function and atrioventricular conduction before and after administration of intravenous atropine (0.02 mg/kg) was performed. Electrophysiologic parameters of sinus node function were normal in 12 of 15 patients (80%) and atrioventricular (AV) nodal function was normal in 7 patients (47%). Almost all abnormal findings of sinus node function and AV nodal function were reversible by administration of atropine. The HisPurkinje system function was normal in 6 patients (40%). Prolonged HV intervals (57 to 73 ms) were found in 9 patients (60%). Intra- or infra-His block was not observed in any patient. In summary, electrophysiologic parameters of sinus node function and AV conduction were normal or only slightly abnormal in all 15 study patients, which suggests that prolonged ventricular asystole during obstructive sleep apnea is not due to fixed or anatomic disease of the sinus node or the AV conduction system.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8677871</pmid><doi>10.1016/S0002-9149(96)00197-X</doi><tpages>5</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1996-06, Vol.77 (15), p.1310-1314 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| subjects | Atrioventricular Node - physiopathology Atropine Biological and medical sciences Cardiac Catheterization Cardiac Pacing, Artificial Cardiovascular disease Coronary vessels Electrocardiography, Ambulatory Female Heart Heart Arrest - diagnosis Heart Arrest - etiology Heart Arrest - physiopathology Heart Rate - drug effects Humans Male Medical research Medical sciences Middle Aged Non tumoral diseases Otorhinolaryngology. Stomatology Polysomnography Positive-Pressure Respiration Sinoatrial Node - physiopathology Sleep Apnea Syndromes - complications Sleep Apnea Syndromes - physiopathology Sleep Apnea Syndromes - therapy Sleep disorders Time Factors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Electrophysiologic evaluation of sinus node function and atrioventricular conduction in patients with prolonged ventricular asystole during obstructive sleep apnea |
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