Enhancement of mitochondrial tyrosine kinase activity following viral transformation
A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitoc...
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Veröffentlicht in: | Cancer letters 1988-02, Vol.39 (1), p.1-8 |
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creator | Piedimonte, Giuseppe Silvotti, Lucia Borghetti, Angelo F. Montagnier, Luc |
description | A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitochondrial fraction. At all the culture conditions tested this enzyme activity always resulted several fold higher in the virus-transformed cells than in the normal parental cells. |
doi_str_mv | 10.1016/0304-3835(88)90034-1 |
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The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitochondrial fraction. At all the culture conditions tested this enzyme activity always resulted several fold higher in the virus-transformed cells than in the normal parental cells.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(88)90034-1</identifier><identifier>PMID: 2830962</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Cell Transformation, Viral ; Cells, Cultured ; Culture Media ; Enzymes and enzyme inhibitors ; Fundamental and applied biological sciences. 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The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitochondrial fraction. At all the culture conditions tested this enzyme activity always resulted several fold higher in the virus-transformed cells than in the normal parental cells.</description><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Transformation, Viral</subject><subject>Cells, Cultured</subject><subject>Culture Media</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mitochondria - enzymology</subject><subject>Mitochondrial fraction</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Simian virus 40</subject><subject>Transferases</subject><subject>Tryosine protein kinase</subject><subject>Viral transformation</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhq2qCNLAPyjSHipUDlv8sV57L0goSlskpF7gbHm942LYtVPbSZV_j9NEORbNwYd55tXMY4Q-E_yNYNLeYIabmknGv0p53WHMmpp8QDMiBa1FJ_FHNDsiZ-hTSi8YY94IfopOqWS4a-kMPS79s_YGJvC5CraaXA7mOfghOj1WeRtDch6qV-d1gkqb7DYubysbxjH8df53tXFxB0btkw1x0tkFf45OrB4TXBzeOXr6vnxc_Kwffv24X9w91KYhItdg8CAoJ4JK6LntmwZAakvswFkPtuVDB9oK1vasM1x2mkpMbW9NgRm1ms3R1T53FcOfNaSsJpcMjKP2ENZJCUkIY618FyS8FGloAZs9aMrhKYJVq-gmHbeKYLWzrnZK1U6pklL9s65IGbs85K_7CYbj0EFz6X859HUyerTFlnHpiAlMWckt2O0egyJt4yCqZByU3xlcBJPVENz_93gDjxmgGg</recordid><startdate>19880201</startdate><enddate>19880201</enddate><creator>Piedimonte, Giuseppe</creator><creator>Silvotti, Lucia</creator><creator>Borghetti, Angelo F.</creator><creator>Montagnier, Luc</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19880201</creationdate><title>Enhancement of mitochondrial tyrosine kinase activity following viral transformation</title><author>Piedimonte, Giuseppe ; Silvotti, Lucia ; Borghetti, Angelo F. ; Montagnier, Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-ec0d7251728eb5fb44ee8af1fd53bef65d9eaf736b39c589a2802fbfcb5f32fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Transformation, Viral</topic><topic>Cells, Cultured</topic><topic>Culture Media</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mitochondria - enzymology</topic><topic>Mitochondrial fraction</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Simian virus 40</topic><topic>Transferases</topic><topic>Tryosine protein kinase</topic><topic>Viral transformation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piedimonte, Giuseppe</creatorcontrib><creatorcontrib>Silvotti, Lucia</creatorcontrib><creatorcontrib>Borghetti, Angelo F.</creatorcontrib><creatorcontrib>Montagnier, Luc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piedimonte, Giuseppe</au><au>Silvotti, Lucia</au><au>Borghetti, Angelo F.</au><au>Montagnier, Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of mitochondrial tyrosine kinase activity following viral transformation</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>39</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. 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subjects | Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cell Transformation, Viral Cells, Cultured Culture Media Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Mitochondria - enzymology Mitochondrial fraction Protein-Tyrosine Kinases - metabolism Simian virus 40 Transferases Tryosine protein kinase Viral transformation |
title | Enhancement of mitochondrial tyrosine kinase activity following viral transformation |
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