Enhancement of mitochondrial tyrosine kinase activity following viral transformation

A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitoc...

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Veröffentlicht in:Cancer letters 1988-02, Vol.39 (1), p.1-8
Hauptverfasser: Piedimonte, Giuseppe, Silvotti, Lucia, Borghetti, Angelo F., Montagnier, Luc
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container_issue 1
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container_title Cancer letters
container_volume 39
creator Piedimonte, Giuseppe
Silvotti, Lucia
Borghetti, Angelo F.
Montagnier, Luc
description A tyrosine protein kinase activity has been detected in the mitochondrial fraction purified from normal and virus-transformed cultured cells. The addition of serum to cells whose growth was restricted by serum limitation induced a marked decrease of tyrosine kinase activity associated with the mitochondrial fraction. At all the culture conditions tested this enzyme activity always resulted several fold higher in the virus-transformed cells than in the normal parental cells.
doi_str_mv 10.1016/0304-3835(88)90034-1
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Cell Transformation, Viral
Cells, Cultured
Culture Media
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Mitochondria - enzymology
Mitochondrial fraction
Protein-Tyrosine Kinases - metabolism
Simian virus 40
Transferases
Tryosine protein kinase
Viral transformation
title Enhancement of mitochondrial tyrosine kinase activity following viral transformation
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