Holotranscobalamins in B12 and non B12 requiring prokaryotes and eukaryotes

Holotranscobalamins in B12 and non B12 requiring prokaryotes and eukaryotes

Transcobalamins, vitamin B12 binding proteins, deliver B12 to cell surface receptors which then permit B12 to cross cell membranes for metabolic use. There is little documentation concerning B12 binding proteins in bacteria and protists. We found that prokaryotes and eukaryotes requiring B12, as wel...

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Veröffentlicht in:Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 1996-04, Vol.113 (4), p.707-709
Hauptverfasser: Baker, Herman, DeAngelis, Barbara, Khalil, Marcelle, Frank, Oscar, Baker, Elliott R.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cobalamins
Culture Media
Erythrocytes - metabolism
Escherichia coli - metabolism
Euglena gracilis - metabolism
Eukaryota - metabolism
eukaryotes
HeLa Cells
holotranscobalamins
Humans
Lactobacillus - metabolism
prokaryotes
Protein Binding
Species Specificity
transcobalamins
Transcobalamins - biosynthesis
Transcobalamins - metabolism
Vitamin B 12 - metabolism
vitamin B12
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Zusammenfassung:Transcobalamins, vitamin B12 binding proteins, deliver B12 to cell surface receptors which then permit B12 to cross cell membranes for metabolic use. There is little documentation concerning B12 binding proteins in bacteria and protists. We found that prokaryotes and eukaryotes requiring B12, as well as those protists synthesizing B12, also produce several transcobalamins for functionally transporting B12 similar to humans.
ISSN:1096-4959
1879-1107
DOI:10.1016/0305-0491(95)02096-9