The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormal...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1988-02, Vol.239 (4840), p.617-622 |
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| creator | Fauci, Anthony S. |
| description | Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals. |
| doi_str_mv | 10.1126/science.3277274 |
| format | Article |
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HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3277274</identifier><identifier>PMID: 3277274</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - microbiology ; Acquired Immunodeficiency Syndrome - psychology ; AIDS ; AIDS (Disease) ; AIDS/HIV ; Antigens ; B lymphocytes ; Biological and medical sciences ; Causes of ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV (Viruses) ; HIV - pathogenicity ; HIV infections ; Human immunodeficiency virus ; Humans ; Immunity (Disease) ; Infections ; Medical research ; Mental Disorders - etiology ; Microbiology ; Molecules ; Monocytes ; Nervous System Diseases - etiology ; Physiological aspects ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; T lymphocytes ; Virology ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1988-02, Vol.239 (4840), p.617-622</ispartof><rights>Copyright 1988 The American Association for the Advancement of Science</rights><rights>1988 INIST-CNRS</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1988 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Feb 5, 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c836t-319ff1a52d493efba3990b7ac9625d7118f78e31f13f6b91c5309d293e82b5073</citedby><cites>FETCH-LOGICAL-c836t-319ff1a52d493efba3990b7ac9625d7118f78e31f13f6b91c5309d293e82b5073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1700182$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1700182$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,2888,2889,27933,27934,58026,58259</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7602528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3277274$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fauci, Anthony S.</creatorcontrib><title>The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - microbiology</subject><subject>Acquired Immunodeficiency Syndrome - psychology</subject><subject>AIDS</subject><subject>AIDS (Disease)</subject><subject>AIDS/HIV</subject><subject>Antigens</subject><subject>B lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Causes of</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV - pathogenicity</subject><subject>HIV infections</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunity (Disease)</subject><subject>Infections</subject><subject>Medical research</subject><subject>Mental Disorders - etiology</subject><subject>Microbiology</subject><subject>Molecules</subject><subject>Monocytes</subject><subject>Nervous System Diseases - etiology</subject><subject>Physiological aspects</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>T lymphocytes</subject><subject>Virology</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN099vEyEcAHBiNLNWn33R5LIYfZjd-NEDzrfZaNekWhPnXi-U-9LS3MGEO2P_e5m9bNM0WcMDCd8PX-ALIPSS4FNCKD-L2oLTcMqoEFSMH6EBwUU-Kihmj9EAY8ZHEov8KXoW4wbjFCvYETrq-QDNL9eQXXSNctmsaTrnKzD2b85tdmVDFz9kM2dAt_aXbbeZclX2BfRaORubmHmTfVPt2q_AQbTxOXpiVB3hRd8P0Y_Pny4nF6P5YjqbnM9HWjLejhgpjCEqp9W4YGCWihUFXgqlC07zShAijZDAiCHM8GVBdM5wUdFkJV3mWLAhervLex38zw5iWzY2aqhr5cB3sRSSYEEYfxAynoqQHwBp2hTj8mFIxpKOc0ITPP4PbnwXXCpLSsbSiQgdJ3SyQytVQ2md8W1Q-qaaQdXepatIw-eccY7TpCF6v0enVkFj9R7-7h-eRAu_25XqYixn378eKhdXh8qP0wOlnM7vy5N9Uvu6hhWU6eVMFvf12U7r4GMMYMrrYBsVtiXB5c2XKPsvUfZvPM143d9Et2yguvV38Td9XEWtahOU0zbeMpGWzalM7NWObWLrw92qAmMiKfsDyZAXyg</recordid><startdate>19880205</startdate><enddate>19880205</enddate><creator>Fauci, Anthony S.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19880205</creationdate><title>The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis</title><author>Fauci, Anthony S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c836t-319ff1a52d493efba3990b7ac9625d7118f78e31f13f6b91c5309d293e82b5073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - 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Science)</jtitle><addtitle>Science</addtitle><date>1988-02-05</date><risdate>1988</risdate><volume>239</volume><issue>4840</issue><spage>617</spage><epage>622</epage><pages>617-622</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3277274</pmid><doi>10.1126/science.3277274</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1988-02, Vol.239 (4840), p.617-622 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78107136 |
| source | JSTOR Archive Collection A-Z Listing; MEDLINE; Science Magazine |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - microbiology Acquired Immunodeficiency Syndrome - psychology AIDS AIDS (Disease) AIDS/HIV Antigens B lymphocytes Biological and medical sciences Causes of Fundamental and applied biological sciences. Psychology HIV HIV (Viruses) HIV - pathogenicity HIV infections Human immunodeficiency virus Humans Immunity (Disease) Infections Medical research Mental Disorders - etiology Microbiology Molecules Monocytes Nervous System Diseases - etiology Physiological aspects Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T lymphocytes Virology Viruses |
| title | The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis |
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