Comparison of Tc-99m HIG and Ga-67 citrate in the evaluation of bacterial abscess in a rat model
Tc-99m labeled polyclonal human immunoglobulin (HIG) has been shown to be able to localize an inflammatory site. There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes a...
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| Veröffentlicht in: | Annals of nuclear medicine 1996-02, Vol.10 (1), p.79-83 |
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| container_title | Annals of nuclear medicine |
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| creator | Güngör, F Karayalçin, B Gültekin, M Paksoy, N Sentürk, U K Kaputlu, I Yildiz, A Erkiliç, M |
| description | Tc-99m labeled polyclonal human immunoglobulin (HIG) has been shown to be able to localize an inflammatory site. There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes and binding directly to bacteria. In this study, we compared Tc-99m HIG and Ga-67 citrate scintigraphy in localizing acute bacterial abscesses induced by E. coli and S. aureus. Serial scintigrams were performed at 1, 4, 24 hr after injection. Tc-99m HIG showed greater accumulation at all times with both infections agents than Ga-67 citrate (p < 0.05). While Tc-99m HIG showed greater accumulation in S. aureus than E. coli (p < 0.05), there was no statistically significant difference between E. coli and S. aureus (p > 0.05) by Ga-67 citrate. Our study suggests that Tc-99m HIG is a superior agent to Ga-67 and bacterial affinity can be a factor responsible for HIG accumulation at focal sites of inflammation. |
| doi_str_mv | 10.1007/bf03165057 |
| format | Article |
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There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes and binding directly to bacteria. In this study, we compared Tc-99m HIG and Ga-67 citrate scintigraphy in localizing acute bacterial abscesses induced by E. coli and S. aureus. Serial scintigrams were performed at 1, 4, 24 hr after injection. Tc-99m HIG showed greater accumulation at all times with both infections agents than Ga-67 citrate (p < 0.05). While Tc-99m HIG showed greater accumulation in S. aureus than E. coli (p < 0.05), there was no statistically significant difference between E. coli and S. aureus (p > 0.05) by Ga-67 citrate. 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There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes and binding directly to bacteria. In this study, we compared Tc-99m HIG and Ga-67 citrate scintigraphy in localizing acute bacterial abscesses induced by E. coli and S. aureus. Serial scintigrams were performed at 1, 4, 24 hr after injection. Tc-99m HIG showed greater accumulation at all times with both infections agents than Ga-67 citrate (p < 0.05). While Tc-99m HIG showed greater accumulation in S. aureus than E. coli (p < 0.05), there was no statistically significant difference between E. coli and S. aureus (p > 0.05) by Ga-67 citrate. Our study suggests that Tc-99m HIG is a superior agent to Ga-67 and bacterial affinity can be a factor responsible for HIG accumulation at focal sites of inflammation.</description><subject>Abscess - diagnostic imaging</subject><subject>Animals</subject><subject>Citrates</subject><subject>Citric Acid</subject><subject>Disease Models, Animal</subject><subject>Escherichia coli Infections - diagnostic imaging</subject><subject>Evaluation Studies as Topic</subject><subject>Gallium Radioisotopes</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Radionuclide Imaging</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Staphylococcal Infections - diagnostic imaging</subject><subject>Technetium</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotVY37oWsXAijuclMHkst9gEFN3U93plJcGQeNckI_vtOaXV14fCdw-Uj5BbYIzCmngrHBMiMZeqMTEHLNJGpEOdkygykiQKtLslVCF-McZ1pPiETrSFVAqbkY963O_R16DvaO7otE2NaulovKXYVXWIiFS3r6DFaWnc0flpqf7AZMNbHRoFltL7GhmIRShvCAUM6FmjbV7a5JhcOm2BvTndG3hev2_kq2bwt1_PnTVJyw2OSoigKsMJVwinhOEgwWarAWKaEcpIDjmHBHBquTCW0EVKlIAxkzikJYkbuj7s7338PNsS8rcd_mgY72w8hVxqY5OYAPhzB0vcheOvyna9b9L85sPygM39Z_Okc4bvT6lC0tvpHT_7EHmoybFY</recordid><startdate>199602</startdate><enddate>199602</enddate><creator>Güngör, F</creator><creator>Karayalçin, B</creator><creator>Gültekin, M</creator><creator>Paksoy, N</creator><creator>Sentürk, U K</creator><creator>Kaputlu, I</creator><creator>Yildiz, A</creator><creator>Erkiliç, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199602</creationdate><title>Comparison of Tc-99m HIG and Ga-67 citrate in the evaluation of bacterial abscess in a rat model</title><author>Güngör, F ; Karayalçin, B ; Gültekin, M ; Paksoy, N ; Sentürk, U K ; Kaputlu, I ; Yildiz, A ; Erkiliç, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-4a3bb1e3fd3f73f2161954719e0737f621af21b0fa9279d389367413915ff7613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Abscess - diagnostic imaging</topic><topic>Animals</topic><topic>Citrates</topic><topic>Citric Acid</topic><topic>Disease Models, Animal</topic><topic>Escherichia coli Infections - diagnostic imaging</topic><topic>Evaluation Studies as Topic</topic><topic>Gallium Radioisotopes</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Radionuclide Imaging</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Staphylococcal Infections - diagnostic imaging</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Güngör, F</creatorcontrib><creatorcontrib>Karayalçin, B</creatorcontrib><creatorcontrib>Gültekin, M</creatorcontrib><creatorcontrib>Paksoy, N</creatorcontrib><creatorcontrib>Sentürk, U K</creatorcontrib><creatorcontrib>Kaputlu, I</creatorcontrib><creatorcontrib>Yildiz, A</creatorcontrib><creatorcontrib>Erkiliç, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Güngör, F</au><au>Karayalçin, B</au><au>Gültekin, M</au><au>Paksoy, N</au><au>Sentürk, U K</au><au>Kaputlu, I</au><au>Yildiz, A</au><au>Erkiliç, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Tc-99m HIG and Ga-67 citrate in the evaluation of bacterial abscess in a rat model</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>1996-02</date><risdate>1996</risdate><volume>10</volume><issue>1</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Tc-99m labeled polyclonal human immunoglobulin (HIG) has been shown to be able to localize an inflammatory site. There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes and binding directly to bacteria. In this study, we compared Tc-99m HIG and Ga-67 citrate scintigraphy in localizing acute bacterial abscesses induced by E. coli and S. aureus. Serial scintigrams were performed at 1, 4, 24 hr after injection. Tc-99m HIG showed greater accumulation at all times with both infections agents than Ga-67 citrate (p < 0.05). While Tc-99m HIG showed greater accumulation in S. aureus than E. coli (p < 0.05), there was no statistically significant difference between E. coli and S. aureus (p > 0.05) by Ga-67 citrate. Our study suggests that Tc-99m HIG is a superior agent to Ga-67 and bacterial affinity can be a factor responsible for HIG accumulation at focal sites of inflammation.</abstract><cop>Japan</cop><pmid>8814731</pmid><doi>10.1007/bf03165057</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of nuclear medicine, 1996-02, Vol.10 (1), p.79-83 |
| issn | 0914-7187 1864-6433 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Abscess - diagnostic imaging Animals Citrates Citric Acid Disease Models, Animal Escherichia coli Infections - diagnostic imaging Evaluation Studies as Topic Gallium Radioisotopes Humans Immunoglobulins Radionuclide Imaging Rats Rats, Wistar Staphylococcal Infections - diagnostic imaging Technetium |
| title | Comparison of Tc-99m HIG and Ga-67 citrate in the evaluation of bacterial abscess in a rat model |
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