Role of receptor occupancy in the transition from responsive to unresponsive states in cultured breast tumor cells
Progression from a steroid sensitive to insensitive state is characteristic of breast tumors, but little is known about the molecular mechanisms involved. Changes in steroid receptor can be associated with the progression. This paper reviews the cell culture data pertaining to loss of response and c...
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| Veröffentlicht in: | Journal of cellular biochemistry 1988-01, Vol.36 (1), p.83-89 |
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| container_title | Journal of cellular biochemistry |
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| creator | Darbre, Philippa D. King, Roger J. B. |
| description | Progression from a steroid sensitive to insensitive state is characteristic of breast tumors, but little is known about the molecular mechanisms involved. Changes in steroid receptor can be associated with the progression. This paper reviews the cell culture data pertaining to loss of response and concludes that loss of receptor is a consequence rather than a cause of insensitivity. This view is based on evidence that loss of all response parameters occurs despite the presence of fully functional receptors as determined by transfection experiments. The postreceptor defect appears to be at the level of the hormone response element of the responsive genes arid may involve DNA methylation. The implications of the model for human breast cancer biology are discussed. |
| doi_str_mv | 10.1002/jcb.240360109 |
| format | Article |
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The implications of the model for human breast cancer biology are discussed.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.240360109</identifier><identifier>PMID: 3277987</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; breast cancer ; Breast Neoplasms - physiopathology ; cell biology ; Cell Transformation, Neoplastic ; DNA methylation ; Female ; Humans ; Mammary Neoplasms, Experimental - physiopathology ; Mice ; mouse mammary tumor virus (MMTV) ; receptor phenotypes ; Receptors, Steroid - physiology ; steroid sensitivity/insensitivity ; tissue culture ; transfection ; Tumor Cells, Cultured - metabolism</subject><ispartof>Journal of cellular biochemistry, 1988-01, Vol.36 (1), p.83-89</ispartof><rights>Copyright © 1988 Alan R. Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3749-eec53f5c0370f9a18fa74a0c3d4795babf5a12ad8ff42894dd2bd97b160334e3</citedby><cites>FETCH-LOGICAL-c3749-eec53f5c0370f9a18fa74a0c3d4795babf5a12ad8ff42894dd2bd97b160334e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.240360109$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.240360109$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3277987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Darbre, Philippa D.</creatorcontrib><creatorcontrib>King, Roger J. B.</creatorcontrib><title>Role of receptor occupancy in the transition from responsive to unresponsive states in cultured breast tumor cells</title><title>Journal of cellular biochemistry</title><addtitle>J. Cell. Biochem</addtitle><description>Progression from a steroid sensitive to insensitive state is characteristic of breast tumors, but little is known about the molecular mechanisms involved. Changes in steroid receptor can be associated with the progression. This paper reviews the cell culture data pertaining to loss of response and concludes that loss of receptor is a consequence rather than a cause of insensitivity. This view is based on evidence that loss of all response parameters occurs despite the presence of fully functional receptors as determined by transfection experiments. The postreceptor defect appears to be at the level of the hormone response element of the responsive genes arid may involve DNA methylation. The implications of the model for human breast cancer biology are discussed.</description><subject>Animals</subject><subject>breast cancer</subject><subject>Breast Neoplasms - physiopathology</subject><subject>cell biology</subject><subject>Cell Transformation, Neoplastic</subject><subject>DNA methylation</subject><subject>Female</subject><subject>Humans</subject><subject>Mammary Neoplasms, Experimental - physiopathology</subject><subject>Mice</subject><subject>mouse mammary tumor virus (MMTV)</subject><subject>receptor phenotypes</subject><subject>Receptors, Steroid - physiology</subject><subject>steroid sensitivity/insensitivity</subject><subject>tissue culture</subject><subject>transfection</subject><subject>Tumor Cells, Cultured - metabolism</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1DAURi1EVYbCkiWSV-xSrh8Zx0sYlfKoWhVVdGk5zrVISeJgO8D8ezya0airbmzZ37lHVx8hbxicMwD-_sG151yCWAMD_YysyqkquZbyOVmBElBxwfgL8jKlBwDQWvBTciq4UrpRKxK_hwFp8DSiwzmHSINzy2wnt6X9RPNPpDnaKfW5DxP1MYyFTHMoP39KFOgyPXqnbDOm3aBbhrxE7Ggb0aZM8zIWt8NhSK_IibdDwteH-4zcfbq423yurm4uv2w-XFVOKKkrRFcLXzsQCry2rPFWSQtOdFLpurWtry3jtmu8l7zRsut422nVsjUIIVGckXd77RzD7wVTNmOfdgvYCcOSjGoYSK6ggNUedDGkFNGbOfajjVvDwOwqNqVic6y48G8P4qUdsTvSh05Lrvb5337A7dMy83Xz8bH5sEmfMv47Ttr4y6yVULW5v74030Rzf_uD3ZpG_AcFGJk7</recordid><startdate>198801</startdate><enddate>198801</enddate><creator>Darbre, Philippa D.</creator><creator>King, Roger J. 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B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3749-eec53f5c0370f9a18fa74a0c3d4795babf5a12ad8ff42894dd2bd97b160334e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>breast cancer</topic><topic>Breast Neoplasms - physiopathology</topic><topic>cell biology</topic><topic>Cell Transformation, Neoplastic</topic><topic>DNA methylation</topic><topic>Female</topic><topic>Humans</topic><topic>Mammary Neoplasms, Experimental - physiopathology</topic><topic>Mice</topic><topic>mouse mammary tumor virus (MMTV)</topic><topic>receptor phenotypes</topic><topic>Receptors, Steroid - physiology</topic><topic>steroid sensitivity/insensitivity</topic><topic>tissue culture</topic><topic>transfection</topic><topic>Tumor Cells, Cultured - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Darbre, Philippa D.</creatorcontrib><creatorcontrib>King, Roger J. B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Darbre, Philippa D.</au><au>King, Roger J. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of receptor occupancy in the transition from responsive to unresponsive states in cultured breast tumor cells</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J. Cell. Biochem</addtitle><date>1988-01</date><risdate>1988</risdate><volume>36</volume><issue>1</issue><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>Progression from a steroid sensitive to insensitive state is characteristic of breast tumors, but little is known about the molecular mechanisms involved. Changes in steroid receptor can be associated with the progression. This paper reviews the cell culture data pertaining to loss of response and concludes that loss of receptor is a consequence rather than a cause of insensitivity. This view is based on evidence that loss of all response parameters occurs despite the presence of fully functional receptors as determined by transfection experiments. The postreceptor defect appears to be at the level of the hormone response element of the responsive genes arid may involve DNA methylation. The implications of the model for human breast cancer biology are discussed.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3277987</pmid><doi>10.1002/jcb.240360109</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0730-2312 |
| ispartof | Journal of cellular biochemistry, 1988-01, Vol.36 (1), p.83-89 |
| issn | 0730-2312 1097-4644 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals breast cancer Breast Neoplasms - physiopathology cell biology Cell Transformation, Neoplastic DNA methylation Female Humans Mammary Neoplasms, Experimental - physiopathology Mice mouse mammary tumor virus (MMTV) receptor phenotypes Receptors, Steroid - physiology steroid sensitivity/insensitivity tissue culture transfection Tumor Cells, Cultured - metabolism |
| title | Role of receptor occupancy in the transition from responsive to unresponsive states in cultured breast tumor cells |
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