POTENTIAL FALSE-POSITIVE RESULTS WITH ANTIGEN ENHANCEMENT FOR IMMUNOHISTOCHEMISTRY OF THE p53 GENE PRODUCT IN COLORECTAL NEOPLASMS

Aberrant crypt foci (ACF) are putative precursor lesions of colon cancer, recently identified on the methylene blue‐stained mucosal surface of human colon. No mutations in K‐ras or p53 genes were found by non‐radioactive single‐strand conformation polymorphism analysis in 14 ACF collected from five...

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Veröffentlicht in:	The Journal of pathology 1996-03, Vol.178 (3), p.264-267
Hauptverfasser:	BAAS, INGE O., VAN DEN BERG, FRANK M., MULDER, JAN-WILLEM R., CLEMENT, MARJON J., SLEBOS, ROBBERT J. C., HAMILTON, STANLEY R., OFFERHAUS, G. JOHAN A.
Format:	Artikel
Sprache:	eng
Schlagworte:	allelic loss Antibodies, Monoclonal antigen enhancement Antigens Biological and medical sciences colorectal neoplasms Colorectal Neoplasms - genetics DNA - analysis Electrophoresis False Positive Reactions false positivity Humans immunohistochemistry Immunohistochemistry - methods Intestinal Mucosa - chemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Microwaves Miscellaneous. Technology Mutation p53 Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - immunology
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