Tumour-cell-endothelial interactions : free radicals are mediators of melanoma-induced endothelial cell damage

Damage to vascular endothelium may play an important role during metastasis. We used a three-dimensional model of tumour cell extravasation to test the hypothesis that certain types of tumour cells are able to induce vascular endothelial cell injury. Multicellular tumour spheroids (MCTS) of 14 human...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 1996-05, Vol.428 (2), p.99-106
Hauptverfasser:	OFFNER, F. A, SCHIEFER, J, WIRTZ, H.-C, BIGALKE, I, PAVELKA, M, HOLLWEG, G, ENSINGER, C, KLOSTERHALFEN, B, MITTERMAYER, C, KIRKPATRICK, C. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catalase - pharmacology Coculture Techniques Dermatology Dose-Response Relationship, Drug Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Free Radicals - metabolism Humans Medical sciences Melanoma - pathology Melanoma - physiopathology Microscopy, Electron Microscopy, Electron, Scanning Spheroids, Cellular - pathology Superoxide Dismutase - pharmacology Time Factors Tumor Cells, Cultured - drug effects Tumors of the skin and soft tissue. Premalignant lesions
Online-Zugang:	Volltext
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