Effect of synthetic human cholecystokinin-33 on exocrine pancreas

Synthetic human cholecystokinin-33 was first evaluated with respect to the biological activity on the pancreatic protein secretion. Human cholecystokinin-33 increased pancreatic protein secretion in a dose-related manner. The relative molar potency of this substance compared to that of synthetic cho...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-02, Vol.150 (3), p.1251-1255
Hauptverfasser:	Doi, Ryuichiro, Inoue, Kazutomo, Kogire, Masafumi, Sumi, Shoichiro, Yun, Mitsutoshi, Futaki, Shiroh, Fujii, Nobutaka, Yajima, Haruaki, Tobe, Takayoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cholecystokinin - pharmacology Dogs Exocrine pancreas Fundamental and applied biological sciences. Psychology Humans Pancreas - drug effects Pancreas - metabolism Proteins - metabolism Sincalide - pharmacology Vertebrates: digestive system
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Zusammenfassung:	Synthetic human cholecystokinin-33 was first evaluated with respect to the biological activity on the pancreatic protein secretion. Human cholecystokinin-33 increased pancreatic protein secretion in a dose-related manner. The relative molar potency of this substance compared to that of synthetic cholecystokinin-8 (taken as 1.0) was 0.92. This study supports the concept that longer molecular forms of cholecystokinin are quantitatively important mediators of biological action of cholecystokinin on the pancreas.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(88)90763-2