Rebamipide protects against activation of neutrophils by Helicobacter pylori
Our objectives were to determine whether rebamipide, a unique antiulcer agent, would inhibit adhesive reactions between neutrophils and endothelial cells as well as the production of active oxygen species from neutrophils elicited by an extract of H. pylori. A water extract of H. pylori that was pre...
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| Veröffentlicht in: | Digestive diseases and sciences 1996-06, Vol.41 (6), p.1139-1144 |
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| container_title | Digestive diseases and sciences |
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| creator | YOSHIDA, N YOSHIKAWA, T MUKAI, F KONDO, M IINUMA, S ARAI, M TAKENAKA, S SAKAMOTO, K MIYAJIMA, T NAKAMURA, Y YAGI, N NAITO, Y |
| description | Our objectives were to determine whether rebamipide, a unique antiulcer agent, would inhibit adhesive reactions between neutrophils and endothelial cells as well as the production of active oxygen species from neutrophils elicited by an extract of H. pylori. A water extract of H. pylori that was prepared from biopsy materials obtained from a patient with gastric ulcer increased the surface expression of CD18 on human neutrophils isolated from peripheral blood, the adhesion of neutrophil-endothelial cells, and the production of active oxygen species by neutrophils. Rebamipide, at concentrations of 10(-5) and 10(-6) M, reduced the adherence of neutrophils to endothelial cells as well as the CD18 expression on neutrophils induced by this bacterial extract. Rebamipide also inhibited the production of active oxygen species from neutrophils stimulated by H. pylori extract. These results suggest that rebamipide protects against the gastric mucosal inflammation associated with H. pylori by inhibiting neutrophil function. |
| doi_str_mv | 10.1007/BF02088229 |
| format | Article |
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A water extract of H. pylori that was prepared from biopsy materials obtained from a patient with gastric ulcer increased the surface expression of CD18 on human neutrophils isolated from peripheral blood, the adhesion of neutrophil-endothelial cells, and the production of active oxygen species by neutrophils. Rebamipide, at concentrations of 10(-5) and 10(-6) M, reduced the adherence of neutrophils to endothelial cells as well as the CD18 expression on neutrophils induced by this bacterial extract. Rebamipide also inhibited the production of active oxygen species from neutrophils stimulated by H. pylori extract. These results suggest that rebamipide protects against the gastric mucosal inflammation associated with H. pylori by inhibiting neutrophil function.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02088229</identifier><identifier>PMID: 8654144</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Alanine - analogs & derivatives ; Alanine - pharmacology ; Anti-Ulcer Agents - pharmacology ; Biological and medical sciences ; CD18 Antigens - analysis ; Cell Adhesion ; Digestive system ; Electron Spin Resonance Spectroscopy ; Endothelium, Vascular - physiology ; Flow Cytometry ; Helicobacter pylori - physiology ; Humans ; In Vitro Techniques ; Medical sciences ; Neutrophil Activation - drug effects ; Neutrophils - immunology ; Neutrophils - metabolism ; Pharmacology. Drug treatments ; Quinolones - pharmacology ; Reactive Oxygen Species - metabolism</subject><ispartof>Digestive diseases and sciences, 1996-06, Vol.41 (6), p.1139-1144</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3130559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8654144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIDA, N</creatorcontrib><creatorcontrib>YOSHIKAWA, T</creatorcontrib><creatorcontrib>MUKAI, F</creatorcontrib><creatorcontrib>KONDO, M</creatorcontrib><creatorcontrib>IINUMA, S</creatorcontrib><creatorcontrib>ARAI, M</creatorcontrib><creatorcontrib>TAKENAKA, S</creatorcontrib><creatorcontrib>SAKAMOTO, K</creatorcontrib><creatorcontrib>MIYAJIMA, T</creatorcontrib><creatorcontrib>NAKAMURA, Y</creatorcontrib><creatorcontrib>YAGI, N</creatorcontrib><creatorcontrib>NAITO, Y</creatorcontrib><title>Rebamipide protects against activation of neutrophils by Helicobacter pylori</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Our objectives were to determine whether rebamipide, a unique antiulcer agent, would inhibit adhesive reactions between neutrophils and endothelial cells as well as the production of active oxygen species from neutrophils elicited by an extract of H. pylori. A water extract of H. pylori that was prepared from biopsy materials obtained from a patient with gastric ulcer increased the surface expression of CD18 on human neutrophils isolated from peripheral blood, the adhesion of neutrophil-endothelial cells, and the production of active oxygen species by neutrophils. Rebamipide, at concentrations of 10(-5) and 10(-6) M, reduced the adherence of neutrophils to endothelial cells as well as the CD18 expression on neutrophils induced by this bacterial extract. Rebamipide also inhibited the production of active oxygen species from neutrophils stimulated by H. pylori extract. These results suggest that rebamipide protects against the gastric mucosal inflammation associated with H. pylori by inhibiting neutrophil function.</description><subject>Alanine - analogs & derivatives</subject><subject>Alanine - pharmacology</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>CD18 Antigens - analysis</subject><subject>Cell Adhesion</subject><subject>Digestive system</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Endothelium, Vascular - physiology</subject><subject>Flow Cytometry</subject><subject>Helicobacter pylori - physiology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Neutrophil Activation - drug effects</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - metabolism</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Quinolones - pharmacology</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOSHIDA, N</creatorcontrib><creatorcontrib>YOSHIKAWA, T</creatorcontrib><creatorcontrib>MUKAI, F</creatorcontrib><creatorcontrib>KONDO, M</creatorcontrib><creatorcontrib>IINUMA, S</creatorcontrib><creatorcontrib>ARAI, M</creatorcontrib><creatorcontrib>TAKENAKA, S</creatorcontrib><creatorcontrib>SAKAMOTO, K</creatorcontrib><creatorcontrib>MIYAJIMA, T</creatorcontrib><creatorcontrib>NAKAMURA, Y</creatorcontrib><creatorcontrib>YAGI, N</creatorcontrib><creatorcontrib>NAITO, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIDA, N</au><au>YOSHIKAWA, T</au><au>MUKAI, F</au><au>KONDO, M</au><au>IINUMA, S</au><au>ARAI, M</au><au>TAKENAKA, S</au><au>SAKAMOTO, K</au><au>MIYAJIMA, T</au><au>NAKAMURA, Y</au><au>YAGI, N</au><au>NAITO, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rebamipide protects against activation of neutrophils by Helicobacter pylori</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1996-06-01</date><risdate>1996</risdate><volume>41</volume><issue>6</issue><spage>1139</spage><epage>1144</epage><pages>1139-1144</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>Our objectives were to determine whether rebamipide, a unique antiulcer agent, would inhibit adhesive reactions between neutrophils and endothelial cells as well as the production of active oxygen species from neutrophils elicited by an extract of H. pylori. A water extract of H. pylori that was prepared from biopsy materials obtained from a patient with gastric ulcer increased the surface expression of CD18 on human neutrophils isolated from peripheral blood, the adhesion of neutrophil-endothelial cells, and the production of active oxygen species by neutrophils. Rebamipide, at concentrations of 10(-5) and 10(-6) M, reduced the adherence of neutrophils to endothelial cells as well as the CD18 expression on neutrophils induced by this bacterial extract. Rebamipide also inhibited the production of active oxygen species from neutrophils stimulated by H. pylori extract. These results suggest that rebamipide protects against the gastric mucosal inflammation associated with H. pylori by inhibiting neutrophil function.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8654144</pmid><doi>10.1007/BF02088229</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 1996-06, Vol.41 (6), p.1139-1144 |
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| subjects | Alanine - analogs & derivatives Alanine - pharmacology Anti-Ulcer Agents - pharmacology Biological and medical sciences CD18 Antigens - analysis Cell Adhesion Digestive system Electron Spin Resonance Spectroscopy Endothelium, Vascular - physiology Flow Cytometry Helicobacter pylori - physiology Humans In Vitro Techniques Medical sciences Neutrophil Activation - drug effects Neutrophils - immunology Neutrophils - metabolism Pharmacology. Drug treatments Quinolones - pharmacology Reactive Oxygen Species - metabolism |
| title | Rebamipide protects against activation of neutrophils by Helicobacter pylori |
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