Synthesis and evaluation of 5-amino-1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase

The 5-amino and certain related derivatives of the powerful purine nucleoside phosphorylase (PNPase) inhibitor 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine (TCNR,3) have been prepared and evaluated for their PNPase activity. Acetylation followed by dehydration of 5-chloro-1-beta-D-ribofuran...

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Veröffentlicht in:	Journal of medicinal chemistry 1988-02, Vol.31 (2), p.330-335
Hauptverfasser:	Sanghvi, Yogesh S, Hanna, Naeem B, Larson, Steven B, Fujitaki, James M, Willis, Randall C, Smith, Roberts A, Robins, Roland K, Revankar, Ganapathi R
Format:	Artikel
Sprache:	eng
Schlagworte:	Nucleosides - pharmacology Pentosyltransferases - antagonists & inhibitors Purine-Nucleoside Phosphorylase - antagonists & inhibitors Purines - metabolism Ribavirin - pharmacology Ribonucleosides - chemical synthesis Ribonucleosides - pharmacology X-Ray Diffraction
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