Three-dimensional Solution Structure and Backbone Dynamics of a Variant of Human Interleukin-3

The three-dimensional structure and backbone dynamics of a truncated and multiply substituted recombinant human interleukin-3 (IL-3) variant (SC-65369) have been determined from multidimensional heteronuclear nuclear magnetic resonance spectroscopic data. Sequential application of distance geometry...

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Veröffentlicht in:	Journal of molecular biology 1996-06, Vol.259 (3), p.524-541
Hauptverfasser:	Feng, Yiqing, Klein, Barbara K., McWherter, Charles A.
Format:	Artikel
Sprache:	eng
Schlagworte:	15N NMR relaxation Amino Acid Sequence cytokine structure dynamics four-helical bundle Genetic Variation Granulocyte-Macrophage Colony-Stimulating Factor - chemistry growth factor Humans Interleukin-3 - chemistry Interleukin-5 - chemistry Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Nitrogen Protein Conformation Protein Folding Recombinant Proteins - chemistry Solubility
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