Glycosaminoglycans enhance megakaryocytopoiesis by modifying the activities of hematopoietic growth regulators

We have previously reported that heparin is capable of stimulating in vitro and in vivo megakaryocytopoiesis in mice and has a thrombopoietic effect when given in chronic immune thrombocytopenic purpura and that heparin and several other glycosaminoglycans (GAGs) promote the growth of human megakary...

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Veröffentlicht in:	Journal of cellular physiology 1996-07, Vol.168 (1), p.97-104
Hauptverfasser:	Han, Z. C., Bellucci, S., Shen, Z. X., Maffrand, J. P., Pascal, M., Petitou, M., Lormeau, J., Caen, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Glycosaminoglycans - physiology Growth Substances - physiology Hematopoiesis Interleukin-6 - physiology Male Megakaryocytes - cytology Mice Mice, Inbred BALB C Platelet Factor 4 - physiology Thrombopoietin - physiology Transforming Growth Factor beta - physiology
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