Homozygous Deletion of Mouse Homolog of p16/CDKN2 Gene on Chromosome 4 in Mouse Liver Epithelial Cells in Culture

The culture of hepatocytes isolated from C3H mouse liver results in the spontaneous development of colonies of liver epithelial cells that possess some features of the hepatocytes. These liver epithelial cells frequently have a loss of chromosome 4, and become neoplasms which are hepatocellular carc...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1996/03/15, Vol.19(3), pp.345-349
Hauptverfasser:	MIYASAKA, Kazuyoshi, KAWAUCHI, Saju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Cells, Cultured Chromosomes - physiology DNA Primers Epithelial Cells Epithelium - metabolism Experimental digestive system and abdominal tumors Gene Deletion Genes, Tumor Suppressor - genetics Homozygote immortalization In Situ Hybridization Liver - cytology Liver - metabolism Male Medical sciences Mice Mice, Inbred C3H microsatellite Microsatellite Repeats Molecular Sequence Data mouse homolog p16/CDKN2 Point Mutation Polymerase Chain Reaction tumor suppressor gene Tumors
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