Endotoxemia in obstructive jaundice: observations on cause and clinical significance
Perioperative endotoxemia was detected in 24 of 40 patients who underwent operation for obstructive jaundice (bilirubin level greater than 5.8 mg/dl). Endotoxemia was associated with an increased admission serum bilirubin level (p less than 0.05) and white blood cell count (p less than 0.05) and a d...
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| Veröffentlicht in: | The American journal of surgery 1988-02, Vol.155 (2), p.314-321 |
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| container_title | The American journal of surgery |
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| creator | THOMPSON, J. N COHEN, J MOORE, R. H BLENKHAM, J. I MCCONNELL, J. S MATKIN, J BLUMGART, L. H |
| description | Perioperative endotoxemia was detected in 24 of 40 patients who underwent operation for obstructive jaundice (bilirubin level greater than 5.8 mg/dl). Endotoxemia was associated with an increased admission serum bilirubin level (p less than 0.05) and white blood cell count (p less than 0.05) and a decreased hematocrit value (p less than 0.05), but there was no significant association with other established preoperative risk factors. Patients with preoperative endotoxemia had a decreased immunoglobulin M anti-J5 endotoxin titer (p less than 0.05) and a decreased serum bile acid concentration (p less than 0.05). Preoperative endotoxemia was associated with reduced creatinine clearance before and after operation (p less than 0.05). There was no association between endotoxemia and clinical sepsis, gram-negative infection, or small-bowel colonization. Patients who died had increased preoperative serum fibrin degradation products (p less than 0.05). |
| doi_str_mv | 10.1016/S0002-9610(88)80723-2 |
| format | Article |
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There was no association between endotoxemia and clinical sepsis, gram-negative infection, or small-bowel colonization. Patients who died had increased preoperative serum fibrin degradation products (p less than 0.05).</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(88)80723-2</identifier><identifier>PMID: 3341555</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Biological and medical sciences ; Cholestasis - blood ; Cholestasis - physiopathology ; Cholestasis - surgery ; Endotoxins - blood ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Kidney - physiopathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. 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H</creatorcontrib><creatorcontrib>BLENKHAM, J. I</creatorcontrib><creatorcontrib>MCCONNELL, J. S</creatorcontrib><creatorcontrib>MATKIN, J</creatorcontrib><creatorcontrib>BLUMGART, L. H</creatorcontrib><title>Endotoxemia in obstructive jaundice: observations on cause and clinical significance</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Perioperative endotoxemia was detected in 24 of 40 patients who underwent operation for obstructive jaundice (bilirubin level greater than 5.8 mg/dl). Endotoxemia was associated with an increased admission serum bilirubin level (p less than 0.05) and white blood cell count (p less than 0.05) and a decreased hematocrit value (p less than 0.05), but there was no significant association with other established preoperative risk factors. Patients with preoperative endotoxemia had a decreased immunoglobulin M anti-J5 endotoxin titer (p less than 0.05) and a decreased serum bile acid concentration (p less than 0.05). Preoperative endotoxemia was associated with reduced creatinine clearance before and after operation (p less than 0.05). There was no association between endotoxemia and clinical sepsis, gram-negative infection, or small-bowel colonization. Patients who died had increased preoperative serum fibrin degradation products (p less than 0.05).</description><subject>Biological and medical sciences</subject><subject>Cholestasis - blood</subject><subject>Cholestasis - physiopathology</subject><subject>Cholestasis - surgery</subject><subject>Endotoxins - blood</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Kidney - physiopathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Postoperative Complications - physiopathology</subject><subject>Preoperative Care</subject><subject>Risk Factors</subject><subject>Ursodeoxycholic Acid - therapeutic use</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLw0AUhQdRaq3-hMIsRHQRnUdncuOulPqAggvrOkxmbmRKMqmZpOi_N2Lo6j7Ox-WcS8ics3vOuH54Z4yJJNOc3QLcAUuFTMQJmXJIs4QDyFMyPSLn5CLG3TByvpATMpFywZVSU7JdB9d0zTfW3lAfaFPEru1t5w9Id6YPzlt8_NtiezCdb0KkTaDW9BGpCY7aygdvTUWj_wy-HNpg8ZKclaaKeDXWGfl4Wm9XL8nm7fl1tdwkeyFVl9hMOTUYdcI6UZalMFZiyUFp6ZCpTKVggBW24BJQA8-QuSItpOYci4VBOSM3_3f3bfPVY-zy2keLVWUCNn3MU2CZFsAGcD6CfVGjy_etr037k49vGPTrUTdxCFO2Qwofj1iqNSgQ8hcYfG39</recordid><startdate>19880201</startdate><enddate>19880201</enddate><creator>THOMPSON, J. N</creator><creator>COHEN, J</creator><creator>MOORE, R. H</creator><creator>BLENKHAM, J. 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H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-c95d5883d2cd2fff2ac3ef18563de059578a80bcb138e6819e0db7b3611eb4ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>Cholestasis - blood</topic><topic>Cholestasis - physiopathology</topic><topic>Cholestasis - surgery</topic><topic>Endotoxins - blood</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Kidney - physiopathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Postoperative Complications - physiopathology</topic><topic>Preoperative Care</topic><topic>Risk Factors</topic><topic>Ursodeoxycholic Acid - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMPSON, J. N</creatorcontrib><creatorcontrib>COHEN, J</creatorcontrib><creatorcontrib>MOORE, R. H</creatorcontrib><creatorcontrib>BLENKHAM, J. I</creatorcontrib><creatorcontrib>MCCONNELL, J. S</creatorcontrib><creatorcontrib>MATKIN, J</creatorcontrib><creatorcontrib>BLUMGART, L. 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H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endotoxemia in obstructive jaundice: observations on cause and clinical significance</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>155</volume><issue>2</issue><spage>314</spage><epage>321</epage><pages>314-321</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Perioperative endotoxemia was detected in 24 of 40 patients who underwent operation for obstructive jaundice (bilirubin level greater than 5.8 mg/dl). Endotoxemia was associated with an increased admission serum bilirubin level (p less than 0.05) and white blood cell count (p less than 0.05) and a decreased hematocrit value (p less than 0.05), but there was no significant association with other established preoperative risk factors. Patients with preoperative endotoxemia had a decreased immunoglobulin M anti-J5 endotoxin titer (p less than 0.05) and a decreased serum bile acid concentration (p less than 0.05). Preoperative endotoxemia was associated with reduced creatinine clearance before and after operation (p less than 0.05). There was no association between endotoxemia and clinical sepsis, gram-negative infection, or small-bowel colonization. Patients who died had increased preoperative serum fibrin degradation products (p less than 0.05).</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>3341555</pmid><doi>10.1016/S0002-9610(88)80723-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The American journal of surgery, 1988-02, Vol.155 (2), p.314-321 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cholestasis - blood Cholestasis - physiopathology Cholestasis - surgery Endotoxins - blood Female Gastroenterology. Liver. Pancreas. Abdomen Humans Kidney - physiopathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Postoperative Complications - physiopathology Preoperative Care Risk Factors Ursodeoxycholic Acid - therapeutic use |
| title | Endotoxemia in obstructive jaundice: observations on cause and clinical significance |
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