Quantitating immunosuppression : Estimating the 50% inhibitory concentration for in vivo cyclosporine in mice

Cyclosporine (CsA) blocks T cell responses in vitro by inhibiting the phosphatase activity of calcineurin (CN) and thus preventing the activation of cytokine transcription. In the study presented here, we measured the extent of inhibition of these functions in the tissues of CsA-fed mice. Mice fed i...

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